ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
An experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perf...
COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimatio...
Urolithiasis is a relevant clinical problem in every day practice with a subsequent burden for the health system. Animal models of disease most closely replicate the sum of physiological conditions present in humans. Rats and mice are however, the two most commonly used experimental animals in medical research including stone disease. The oxalate metabolism in the rat is nearly identical to that i...
Pharmacogenetics (PGt) is an established discipline that studies the genetic basis of inter-individual variability in the response to drug therapy and pharmacogenomics (PGx) is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. The goal of p...
An antibiotic may be defined as a substance or compound that kills or inhibits the growth of, bacteria. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections caused by microorganisms, including fungi and protozoa, viruses. Antibiotic de-escalation is a mechanism whereby the provision of effective initial antibiotic treatment is achieved while avoiding unneces...
GREEN SYNTHESIS AND ANTIMICROBIAL ACTIVITY STUDIES OF CURCUMINANILINE FUNCTIONALIZED ZINC OXIDE NANOPARTICLES AND COMPARATIVE STUDIES WITH ITS NON-FUNCTIONALIZED FORM
Biofunctionalization of nanoparticles is an advancement of current nanotechnology and biotechnology fields. Developing biocompatible progressive functional materials possess antimicrobial properties could be hopeful for environmentally benevolent applications. Biofunctionalization of nanomaterials is one such topic to produce the non-toxic and more efficient antimicrobial agents. The present study...
Fluvastatin sodium (FVS) is the first fully synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It shows extensive first pass metabolism with short plasma half-life (3 hrs). The iontophoresis approach was used to determine the permeability of drug through isolated rat skin. In-vitro permeation of drug was determined by using ...
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds...
The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
The present work was aimed to evaluate the potential protective effect of white tea's extract against the liver injury in an experimental model of hepatotoxicity induced by HgCl2 in mice. Histopathological investigations, liver functions and flow. Cytometrical analyses were estimated. The experimental mice were divided into four groups, each of eight mice (each mouse weighed 25 - 30gm): Group 1 wa...