HIGH PREVALENCE OF HOOKWORM INFECTION AND APPARENT ABSENCE OF ASCARIS LUMBRICOIDES: A CASE STUDY AT THE KOMFO ANOKYE TEACHING HOSPITAL IN GHANA
Background: Parasitic helminth infection is one of the major risk factors underlying the high rates of anaemia and malnutrition in many third world countries due to the poor socio-economic and environmental conditions of the people and these play a very significant role in their transmission. Method: 2000 stool specimens collected between May and October 2008 at the Komfo Anokye Teaching Hospit...
Pregnancy is a state of double danger i.e. any drug that a pregnant woman takes can easily cross placenta and can produce a teratogenic effects on fetus. It can interfere with normal embryonic or fetal development and induce abnormal post natal structure or function. Teratogens alter the genetic function of fetus. This review provides practitioners with summary of information regarding teratology ...
The present study has been designed to investigate the effect of modulation of tumour necrosis α (TNF-α) on naloxone induced opioid withdrawal syndrome. Chronic morphine (5mg/kg,i.p) administration followed by a single injection of naloxone (8mg/kg, i.p) was used to precipitate opioid withdrawal syndrome in mice. Behavioral observations were made immediately after naloxone treatment. Withdrawa...
ROLE OF SOLVENT ACCESSIBLE SURFACE AREA (ASA+) AND BALABEN 3D INDEX (J3D) IN BINDING AFFINITY OF TIBO DERIVATIVES
In present QSAR study of TIBO derivatives, aim of the author is to analysis some different 3D parameter in order to get best QSAR model, which enhance the binding affinity of TIBO derivatives. Solvent accessible surface area (3D) of all atoms with positive partial charge (strictly greater than 0) and Balaben 3D index plays vital role in this concern. This study focuses on some important and differ...
Cinnarizine was microencapsulated with Eudragit RS100 using an o/o and o/w emulsion solvent evaporation technique. The effects of three formulation variables including the drug: polymer ratio, emulsifier (polyvinyl alcohol) concentration and volume of external medium on the entrapment efficiency and microspheres size distribution were examined. The drug release rate from prepared microspheres and ...
ETHNOMEDICINAL PLANTS AND THEIR CONTRIBUTION TO CURE VARIOUS AILMENTS AS HOUSEHOLD REMEDIES IN GARHWAL HIMALAYA, INDIA
The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both ...
In the present study, the alcoholic and aqueous extracts of Thespesia populnea were investigated for their antipyretic activity. Suspension of subcutaneous administration of brewer’s yeast in albino rat leads to pyrexia. Oral administration of extracts at a dose of 500 mg/kg body weight significantly reduced the elevated body temperature of rat. This antipyretic effect has been compared with ant...
Nano-emulsions consist of fine oil-in-water or water-in-oil dispersions, having droplets covering the size range of 10 - 600 nm. The aim of this study is to formulate nano-emulsion of Clindamycin by using Emulsion Phase Inversion method and olive oil as the oil phase. Pseudo ternary phase diagram was first developed by using distilled water, olive oil and mixture of surfactants (Tween®80 and Span...
EVALUATION OF IN VITRO IMMUNOMODULATORY EFFECTS OF SOYABEAN (GLYCINE MAX. L) EXTRACTS ON MOUSE IMMUNE SYSTEM
To explore the potentially health modulatory role of most proteinaceous leguminosae plant, Soyabean, the present study was intended to evaluate the in-vitro immunomodulatory activity of dry seeds of Glycine max. L. Effect of ethanolic and methanolic extracts of soyabean was evaluated at various concentrations (800μg/ml to 6.25μg/ml) for secretion of various mediators. Immunomodulatory activity o...