DESIGN AND IN VITRO EVALUATION OF PROCHLORPERAZINE MALEATE BUCCOADHESIVE TABLETS AND COMPARISON OF MONOLAYER, BILAYER AND COMPRESSED COATED TABLETS
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Prochlorperazine maleate is an anti-emetic drug. It was under goes extensive first pass metabolism resulting in an oral bioavailability of 0 to 16 % and it shows variable absorption from GIT. Hence in the present work Buccoadhesive bilayered tablets of Prochlo...
A SIMPLE AND SENSITIVE RP-HPLC METHOD FOR TRACE-LEVEL QUANTIFICATION OF METHYL VINYL KETONE, A POTENTIAL GENOTOXIC IMPURITY, IN DRUG SUBSTANCES
An HPLC method was developed with the aim of quantifying the levels of Methyl Vinyl Ketone (MVK), a Potential Genotoxic Impurity (PGI), in Ivabradine HCl. A limit level concentration of 0.5 ppm for MVK was calculated by applying the concept of Threshold of Toxicological Concern (TTC). The developed HPLC method employs a Phenyl analytical column (150 mm х 4.6 mm, 3.5 μ), 5-μL injection volume, m...
A STUDY ON THE ANTIMICROBIAL PROPERTY OF THE COTTON FABRIC IMPARTED WITH MICHAELIA CHAMPACA LEAF EXTRACT LOADED NANOPARTICLES
In the present work ethanol, methanol, ethyl acetate, chloroform and benzene extract of the Michaelia champaca leaves were screened for their antimicrobial activity. The ethanolic extracts of M. champaca leaves were proved to have the maximum antimicrobial activity; thus the ethanolic leaf extract was selected and the nanoparticles were synthesized using ionic gelification method. The nanopartic...
Danio rerio is one of the best model organisms to study various kinds of disorders. Their genome is fully sequenced and they possess easily detectable developmental properties. The development of their embryo is quite rapid. This is important as the embryos are formed by external fertilization, are large and transparent. Abortifacient is a substance that induces abortion. It can be used in the for...
Endodontic treatment is helpful in saving millions of teeth each year, but at present the focus has shifted towards regenerative approaches as an ideal form of therapy to treat diseased or necrotic pulp tissues. Regeneration of lost tissues has been known for a very long time, but their use in dentistry is gaining momentum. The growing understanding of biological regeneration has permitted the use...
MORPHOMETRY OF THE THYROID GLAND IN DIFFERENT AGE GROUPS IN NORTH INDIAN POPULATION: A CADAVERIC STUDY
Aims and Objectives: The present study was conducted to find out morphometry of thyroid gland in different age groups. Material and Methods: The study was conducted on 60 human thyroid glands in the Department of Anatomy, Pt. B. D. Sharma, PGIMS, Rohtak in North Indian population. Results: In present study, mean length of right and left lobe of thyroid gland was found to be 29.88±7.03 mm and 29.4...
The requirement of drug resistance regularly to plague Tuberculosis control, with vast increase in the spreading of MDR-TB. It can act as a gateway to XDR-TB and then emphasis on the urgency for new drug development and optimal treatment option for Tuberculosis therapy. In this study, we assess the recommending for using Rifabutin (RFB) instead of rifampicin (RIF). The objective of this study and ...
Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblast...
Aim and Objective: To evaluate the antioxidant property of fish oil by its free radical scavenging activity using three different antioxidant models. Materials and Methods: In vitro antioxidant activity of fish oil was evaluated by DPPH radical scavenging activity, lipid peroxidation, ABTS radical scavenging activity using olive oil as positive control. Different concentrations of the fish oil, 0....
EVALUATION OF HEPATOPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF ROOT EXTRACTS OF AEGLE MARMELOS IN CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY WISTAR ALBINO RATS
Herbal medicines are effective in the treatment of various ailments. Very often these drugs are unscientifically exploited and / or improperly used. Therefore plant drugs deserve detailed studies in the light of modern science. The detailed investigation and documentation of plants used in local health traditions and pharmacological evaluation of these plants and their taxonomical relatives can le...