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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 15 (2024) - Issue 3, March

Review Articles

 
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1.

PURPLE TEA: A SYSTEMATIC REVIEW

Camellia sinensis has been used since several decades owing to its numerous health benefits. The purpose of this study is to investigate the developments in new varieties of Camellia sinensis. This new variety of tea possesses striking, purple-colored leaves, and hence, it is more commonly referred to as purple tea. This study analyzes the detailed mechanism of color change. An over-expression of ...

Vishakha G. Thakur *, Niki Jain, Nikita Khule, Nimisha Raut and Talha Siddiqui

Department of Pharmaceutical Chemistry, Viva Institute of Pharmacy, Veer Savarkar Road, Virar East, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).614-25

614-625

651

585

2.

A CUMULATIVE REVIEW ON THERAPEUTICFLORAE USED TOTREAT DIABETES MELLITUS

Diabetes Mellitus is a chronic ailment characterized by clinical manifestations like hyperglycaemia. The development of novel drugs is based on the understand ding of insulin resistance and oxidative damage leading to secondary complications of diabetes such as Retinopathy, Nephropathy etc. In the modern era, there are numerous allopathic drugs available for the treatment of the ailment. Herbs inc...

Sree Mahalakshmi Pasumarthy * and Udaya Guttikonda

Department of Pharmacology, Narayana Pharmacy College, Nellore, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).626-35

626-635

551

288

3.

SCIENTIFIC APPRAISAL OF ROGHAN AHMAR JADEED (UNANI PHARMACOEPIAL OIL) IN THE MANAGEMENT OF PAIN RELATED TO MUSCULOSKELETAL DISORDERS: A REVIEW

Unani Medicine is the ancient system of medicine that deals with prophylactic and therapeutic management of various acute and chronic illnesses. Ilaj bilGhiza, Ilaj bit Tadbeer, Ilaj bid dawa and Ilaj bil yad are the essential modes of treatment in Unani Medicine. A broad term Waja’al-Mafāsil covers entire Musculoskeletal disorders (MSDs) like inflammatory, non-inflammatory, infectious, metabol...

Sadaf T. A. Shaikh *, Mohd. Anwar and Mohammad Yasir

Department of Ilaj Bit Tadbeer, F/o Unani Medicine, AMU, Aligarh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).636-41

636-641

495

223

4.

HETEROCYCLIC COMPOUNDS WITH THEIR RECENT DEVELOPMENT: AN INTEGRATED APPROACH

Organic chemist has developed the number of heterocyclic compounds. The heterocyclic compounds have gained more attention in medicinal and organic chemistry because of their numerous biological activities. There are various types of the heterocyclic compound available for several biological activities such as antibacterial activity, anticancer activity, antiepileptic activity, antipsychotic activi...

P. L. Ladda, S. S. Thorat *, N. N. Khebude and S. B. Powar

Shree Tarun Mandal, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).642-655

642-655

542

223

5.

A REVIEW ON THE POTENTIAL USE OF BLACK GINGER FROM EASTERN INDIA

Kaempferia parviflora Wall. Ex Baker is commonly known as ‘black ginger’ which belongs to the family Zingiberaceae. These are mostly found in the subtropical and tropical areas of Asia. It bears various pharmacological properties such as anticancerous, anti-allergic, anti-inflammatory, antioxidant and antimicrobial. Upon the reports we reviewed the plant aromatic rhizomes contained important p...

Rajashree Panigrahi and Reena Parida *

Molecular Biology and Genetic Engineering Lab, Centre for Biotechnology, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).656-62

656-662

605

234

6.

3D BIOPRINTING AND BEYOND: A TECHNOLOGICAL TRANSFORMATION FOR PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS

3D Bioprinting is a transformational technology that is an indispensable part of the pharmaceutical and biomedical fields. It has been used globally as a cutting-edge tool to improve future prospects. This review encompasses a brief explanation of what exactly 3d bioprinting is, its processing, and how it differs from 3d printing. The elemental segment of bioprinting is bioinks which are biomateri...

S. S. Khatake, A. R. Shirode *, S. N. Salvi, A. A. James and V. J. Kadam

Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).663-80

663-680

161

79

7.

SELENIUM AND CHROMIUM AS ANTIDIABETIC TRACE ELEMENTS: AN OVERVIEW

Trace elements are the dietary factors required by the body in small quantities for normal functioning of the body. The body’s functional skill is negatively impacted by a diet with insufficient trace elements, which lowers the body’s immune function. They are involved in catalyzing different enzymatic reactions. The permissible range of selenium is very narrow. Low levels of selenium have bee...

B. Sarma and P. Saha *

Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Rd, Sahid Colony, Panihati, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).681-89

681-689

138

92

8.

A REVIEW ON PLANT OPILIA CELTIDIFOLIA: AN ASSESSMENT OF ITS BOTANY, CONVENTIONAL UTILIZATION, PHYTOCHEMISTRY AND PHARMACOLOGY

The plant Opilia celtidifolia, often known as ironwood or Opilia, is indigenous to many parts of Africa. It has a long history of traditional use in African herbal medicine, and its purported therapeutic benefits have attracted interest. An overview of Opilia celtidifolia's cultivation, the portions used, and the identification of its chemical components are given in this abstract. The savannahs, ...

Anubhav Dubey, Samra *, Vikram Kumar Sahu, Sribatsa Lanchhana Dash and Amit Mishra

Maharana Pratap College of Pharmacy, Kothi, Mandhana, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).690-98

690-698

146

88

9.

PROBIOTICS: ANAVANT-GARDESTEP INTHE THERAPY OF RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune ailment with multifactorial etiology. The human gut is a massive intricate ecosystem where microbiota, nutrients, and host cells interact extensively to uphold gut homeostasis. Gut microbiota acts as a modulator of immunity and dysbiosis has detrimental effects on health by triggering a persistent inflammatory response that...

Jeel Manish Shah, Bhavini Vinodkumar Sutar, Vivek Sukant Pradhan, Princy Piyushbhai Patel and Pooja Dineshgiri Goswami *

Babaria Institute of Pharmacy, Vadodara, Gujrat, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).699-09

699-709

196

96

Research Articles

 
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10.

SYNTHESIS, CHARACTERIZATION AND ANTICANCER STUDIES OF NOVEL SULPHONAMIDES

Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer agents are major challenges for cancer treatment, which energizes medicinal chemists to develop more anti-cancer agents with high efficiency and low toxicity continuously. sulphonamide derivatives are a class of promising compounds with diverse biological activities including anti-cancer, and parts of them ha...

B. Madhavi and G. Veera Raghava Sharma *

Department of Chemistry, School of Science, Gitam Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).710-25

710-725

427

236

11.

ANTI-ALBUMIN DENATURATION, TRYPSIN INHIBITION AND RBC MEMBRANE STABILIZATION AS POSSIBLE MECHANISM FOR ANTI-INFLAMMATORY ACTIVITY OF METHANOL LEAF EXTRACTS OF SOLANUM SPECIES

In view of rising concern of problem associated with synthetic drugs against inflammation, current research has been focused towards safer, effective and natural compounds. Hence, we aimed at assessing the anti-inflammatory effect of four plants from Solanum species (S. seaforthianum, S. diphyllum, S. sisymbriifollium and S. anguivi) through albumin denaturation assay, trypsin inhibition and RBC m...

M. Renu Priyadarshini and N. Lakshmi Devi *

DOS in Microbiology, University of Mysore, Manasagangotri, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).726-32

726-732

475

221

12.

SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF NEW AURONE DERIVATIVES

Aurones constitute a less studied sub-class of flavonoides which occur rarely in nature. Aurones are responsible for the golden yellow colour of some  flowers. Substituted 2-benzylidene-1-benzofuran-3 (2H)-ones are commonly known as aurones that belong to the naturally occurring flavonoids. In the present investigation, a series of some novel substituted 2-benzylidene-1-benzofuran-3 (2H)-ones (2a...

Madhav M. Kendre * and Ravi R. Vidule

Department of Chemistry, Shri Sant Gadge Maharaj Mahavidyalaya, Loha, Tq. Loha, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).733-38

733-738

372

175

13.

HEPATOPROTECTIVE ACTIVITY OF SINIGRIN AND CARVACROL AGAINST PARACETAMOL INDUCED LIVER INJURY IN WISTAR RATS

Background: Sinigrin (allyl-glucosinolate or 2-propenyl-glucosinolate), an aliphatic glucosinolate, is naturally present in Brassicaceae plants, while carvacrol (2-methyl-5-isopropylphenol) is a monoterpene phenolic component of the essential oil generated by many aromatic plants. This study is aimed to determine the hepatoprotective potential of these phytoconstituents on Paracetamol-induced live...

S. K. Sidhu *, Chawla Anshul, Bajwa Shamsher and Goyal Munish

Department of Pharmaceutical Sciences, Ct University, Ludhiana, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).739-45

739-745

435

188

14.

GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING PRUNUS DOMESTICA (PLUM) FRUIT EXTRACT ITS CHARACTERIZATION, ANTIMICROBIAL AND ANTIOXIDANT STUDIES

Production of nanoparticles using plants is a new area of interest. Plum fruit extract was used for the biosynthesis of zinc oxide nanoparticles. Green synthesis of zinc oxide nanoparticles are considered as a eco-friendly methodusing materials from plants and other natural sources without using anyharmful chemicals. Plum fruit has many medicinal values such as antioxidant activity, cardiovascular...

V. Asha Ranjani *, G. Anusha, B. Pravallika and K. Nikitha Kanthi

Malla Reddy Pharmacy College, Maisammguda, Dhulapally, Medchal, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).746-55

746-755

490

197

15.

A NOVEL THERAPEUTIC EFFECT OF THE WOUND HEALING ACTIVITY OF BOSWELLIA SERRATA EXTRACT (BOSWEGEX®) BY USING THE HUMAN DERMAL FIBROBLAST (HDF) CELL LINE: AN IN-VITRO STUDY

The Indian medicinal plant Boswellia serrata, sometimes known as frankincense in the West, has been used in traditional medicine to heal burns and wounds. The objective of this study was to investigate the capability of B. serrata (Boswegex®) to enhance wound healing by carrying out an in-vitro scratch experiment on human dermal fibroblast cells (HDF). Povidone-Iodine 5% cream was used as a posit...

C. A. Anzar, M. V. Joseph, R. Sundaram, G. B. Vadiraj *, C. P. Prasad and Bineesh Eranimose

R&D Centre, Ingex Botanicals Pvt. Ltd, Nelamangala, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).756-62

756-762

156

100

16.

DEVELOPMENT AND CHARACTERIZATION OF ACECLOFENAC-LOADED NANOSPONGE GEL FOR THE MANAGEMENT OF RHEUMATOID ARTHRITIS

Rheumatoid arthritis is an autoimmune and inflammatory disease, in which immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. Aceclofenac is a phenyl acetic acid derivative and NSAID with anti-inflammatory, analgesic and antipyretic effects. Nanosponges were prepared by the Emulsion solvent diffusion method with var...

Sherin Koshy, Celestie George * and Shajan Abraham

Nazareth College of Pharmacy, Othera P.O Thiruvalla, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).763-70

763-770

145

87

17.

BOERAVINONE B AND CHEBULINIC ACID AMELIORATE ASPARTAME INDUCED TOXICITY IN HEPG2 CELLS BY REGULATING CELL DEATH PATHWAYS

Aspartame is the most common artificial sweetener which is known to induce oxidative stress. Our goal was to determine whether Boeravinone B and Chebulinic acid protect HepG2 cells against Asp-induced oxidative stress in HepG2 on a multifarious level. In this investigation we have addressed ameliorative role of BB and CA in due course of Asp exposure by evaluating biochemical and molecular paramet...

S. S. Kakade, H. K. Bote and P. K. Pawar *

Department of Biotechnology, Shivaji University, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).771-82

771-782

130

90

18.

GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS FROM THE METHANOLIC EXTRACT OF WHOLE PLANT OF CYNODON DACTYLON (L.) PERS.

Plants have been an important source of medicine with qualities for thousands of years. The therapeutic effects in the plants are due to the chemical compounds there in. Cynodon dactylon (L) Pers commonly known as Bermuda grass belongs to the family Poaceae. In ethnomedicinal practices, the plant Cynodon dactylon used in the treatment of various diseases and has pharmacological actions. Its health...

Gurpreet Kaura *, Vir Vikramb and Vijender Kumarc

Department of Pharmacognosy, Akal College of Pharmacy & Technical Education, Mastuana Sahib, Sangrur, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).783-87

783-787

153

87

19.

THERAPEUTIC EFFECT OF LEAVES OF AYAPANA TRIPLINERVIS IN INDOMETHACIN INDUCED MILD, MODERATE AND SEVERE GRADE GASTRIC ULCER

Peptic ulcer disease (PUD) is increasing gradually in India as well as worldwide. Excess use of non-steroidal anti-inflammatory agents (NSAID) and lifestyle factors cause gastric mucosal damage. This study was designed to search out the gastro-protective efficacy of hydromethanolic extract of Ayapana triplinervis on different graded ulcers. Mild to severe grade of gastric ulcer has been developed ...

Ratnabali Maity, Prabir Mondal, Parag Ranjita Bera, Sayandev Midya and Chhanda Mallick *

Department of Biomedical Laboratory Science & Management, Vidyasagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).788-99

788-799

151

88

20.

IN-SILICO PHARMACOKINETIC PROPERTIES PREDICTION OF COUMARINS PRESENT IN AEGLE MARMELOS L.

Aegle marmelos L. (Bael Fruit) is rich in bioactive compounds such as coumarins, alkaloids, terpenoids, tannins, flavonoids, and essential oils. This article focused on the pharmacokinetic profiling of coumarins present using an in silico ADME tool called SwissADME which contributes to a better understanding of enhanced drug monitoring and individualization of drug therapy. Log S (ESOL), Log S (Al...

S. A. Agrawal *, S. R. Dhamne and P. S. Shinde

Bharati Vidyapeeth's College of Pharmacy, Sector-8, C.B.D., Belapur, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).800-07

800-807

162

96

21.

ELECTROCHEMICAL AND PHARMACOLOGICAL ANALYSIS OF CU-ATROPINE COMPLEX

The Cu-Atropine complex may have potential applications in medicinal chemistry, as atropine is used in the treatment of certain medical conditions such as bradycardia and as a pre-anesthetic to decrease salivation. Additionally, the complexation of atropine with copper could potentially enhance its therapeutic effects or alter its pharmacokinetic properties. In the present study, the drug has been...

Rakesh Choure * and S. K. Abdus Samim

Department of Chemistry, Government SSP College Waraseoni, Balaghat, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).808-12

808-812

129

87

22.

PHYTOCHEMICAL ANALYSIS, ELEMENTAL CONTENT, AND FIBROBLAST PROLIFERATION ACTIVITY OF THE HYDRO-ETHANOLIC EXTRACT OF MORINGA OLEIFERA LAM LEAVES

Moringa oleifera is one plant that is multi-purposefully used for the prevention and treatment of numerous diseases. This study analyzed the phytochemical and elemental contents of M. oleifera leaf extract, and evaluated its effect on fibroblast proliferation, which is crucial for wound healing. M. oleifera leaf samples were collected, identified, and extracted using solvents of different polariti...

E. Oppong Bekoe *, E. Orman, N. A. Offei, K. Donkor and A. R. Aikins

Department of Pharmacognosy & Herbal Medicine, School of Pharmacy, University of Ghana, Ghana.

DOI: 10.13040/IJPSR.0975-8232.15(3).813-21

813-821

140

95

23.

PHARMACOGNOSTIC, MYCOBACTERICIDAL, AND MUTAGENIC INVESTIGATIONS OF THE LEAVES OF CLERODENDRUM SPLENDENS G. DON

C. splendens is a medicinal plant used for various ailments within the West-African Community. This study sought to investigate the pharmacognostic characteristics, mycobactericidal, and mutagenic activities of the hydro-ethanolic leaves extract C. splendens. The organoleptic, microscopic, macroscopic and physicochemical characteristics were investigated according to WHO, 2011 quality control meth...

E. Oppong Bekoe *, C. Kitcher, P. Debrah and S. Martinson

Department of Pharmacognosy and Herbal Medicine, School of Pharmacy, University of Ghana, Accra, Ghana.

DOI: 10.13040/IJPSR.0975-8232.15(3).822-28

822-828

122

87

24.

PRESCRIPTION ANALYSIS IN THE PATIENTS ADMITTED TO THE EMERGENCY MEDICINE DEPARTMENT AT TERTIARY CARE TEACHING HOSPITAL

Introduction: The Emergency Medicine Department presents distinct challenges, both diagnostic uncertainty and time constraints. Promptly administering the right drugs in this setting can be crucial for saving lives. Hence, we conducted a study to analyse the prescriptions in the patients admitted to Emergency Medicine Department. Method: This is a prospective, observational single center study con...

Harsh Joshi, Sravya Pinnamaneni, Sapna Gupta * and Kartik Shah

Department of Emergency Medicine, SVP Hospital, NHL Municipal Medical College, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).829-36

829-836

148

112

25.

SPECTRUM OF PAP SMEAR CYTOLOGY IN WOMEN PRESENTING IN A TERTIARY CARE CENTER, TRICHY DISTRICT, SOUTHERN INDIA

Introduction: Carcinoma cervix is the major health problem with increased morbidity and mortality. Around 60% of cases are diagnosed at an advanced stage, making the treatment more complex. Pap smear can able to detect precancerous and cancer of cervix along with infection and inflammatory pathologies making the clinician in timely and appropriate management. Objective: This study aims at detectin...

P. Balamanikandaraja * and G. Jeevaraj

Department of Pathology, Annapoorana Medical College and Hospitals, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).837-43

837-843

130

72

26.

IN-VITRO INHIBITION AND DISSOLUTION OF CALCIUM OXALATE STONES BY THE FRACTIONS OF THE ZIZIPHUS LOTUS L. LEAVES

Nowadays, many clinical studies have provided reliable results on the effects of several herbal medicines on many diseases such as kidney problems. The objective of this study is to evaluate in-vitro the antiurolithiatic activity of polyphenols, flavonoids, and alkaloids fractions of the leaves of the species Ziziphus lotus. The quantification of the polyphenol and flavonoid fractions was carried ...

Ahmed Bensatal

Laboratory Physico-chemistry of Materials and Environment, Faculty of Exact Science and Computer Science, University ZianeAchour, BP 3117, Djelfa, Algeria.

DOI: 10.13040/IJPSR.0975-8232.15(3).844-53

844-853

144

94

27.

THE INCIDENCE AND NATURE OF DRUG-RELATED PROBLEMS AMONG INPATIENTS IN A TERTIARY CARE HOSPITAL IN NORTHERN INDIA: A PROSPECTIVE STUDY

The advancement of drug therapy has undoubtedly elevated patient care standards. However, it has also given rise to an increase in Drug-Related Problems (DRPs), which can significantly disrupt health outcomes. In an 18-month prospective observational study involving 2,000 patients, we meticulously assessed DRPs using the Hepler and Strand classification system. These DRPs encompassed a range of is...

Shanu Raina, Kunal Sharma, Navpreet Kaur * and Priya Jaswal

Department of Pharmacology, Maharishi Markandeshwar Medical College & Hospital, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).854-59

854-859

138

82

28.

FORMULATION AND EVALUATION OF A POLY-HERBAL GEL CONTAINING OXALIS CORNICULATA AND PORTULACA OLERACEA LEAF EXTRACTS: A TOPICAL APPROACH

Introduction: Oxalis corniculata (Family: Oxalidaceae) is a delicate therapeutic herb found in warm temperate tropical areas of India and Pakistan, while Portulaca oleracea (Family: Portulacaceae) thrives in sultry, equatorial regions and has origins in South America and Africa. This study aims to develop and assess a topical poly-herbal gel containing leaf extracts of Oxalis corniculata and Portu...

M. Kubade, P. Shetti * and V. Kumbar

Department of Biotechnology, KAHER’s Dr. Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).860-68

860-868

142

118

29.

PRESCRIBING PRACTICES OF TOPICAL CORTICOSTEROIDS IN THE OUTPATIENT DERMATOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL

Introduction: Topical corticosteroids are mainstay of treatment for many skin conditions but extensive prescription of them may lead to increase in adverse reactions. So, periodic audit of prescriptions will help in enhancing the therapeutic effectiveness and reduce the adverse effects. Objective: To study sociodemographic data and drug prescription pattern in patients with skin diseases. Methodol...

R. R. Patel *, B. N. Karelia, D. V. Shah and A. V. Vyas

Department of Pharmacology, Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).869-73

869-873

150

83

30.

PHARMACIST’S ROLE IN REPORTING AND PREVENTING MEDICATION ERRORS AT A GENERAL HOSPITAL IN MAKKAH, SAUDI ARABIA

Background: Medication errors significantly impact patient morbidity and mortality. Due to their specialized expertise, pharmacists are essential in detecting and averting these errors. Methods: This study evaluated pharmacists' roles in reporting and preventing medication errors at King Faisal Hospital in Makkah, Saudi Arabia. Using a cross-sectional method, we analyzed medication error reports t...

Reema Mashhour Alsharif *, Haneen Badi Alharbi and Khalid R. A. Abdellatif

Department of Clinical Pharmacy, King Faisal Hospital, Makkah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.15(3).874-83

874-883

151

83

31.

A COMPARATIVE ANALYSIS OF GLASGOW COMA SCALE SCORE WITH FULL OUTLINE OF UNRESPONSIVENESS SCORE IN ASSESSMENT OF PATIENTS WITH TRAUMATIC HEAD INJURY IN INTENSIVE CARE UNIT: A TERTIARY CARE CENTRE STUDY

Background: Neurological assessment of traumatic brain injury patients is of prime importance as it affects the therapeutic and prognostic decisions. GCS (Glasgow Coma Scale), a well recognised and often used scoring system in such cases has some drawbacks. We compared FOUR score (Full Outline of Unresponsiveness) with GCS with an objective to test its validity as an alternative to assess the seve...

G. K. Vishwas, Bojja Paul Shravan Kumar, Ubaid Zaheer Siddiqui and B. R. Kiran *

Department of Anesthesiology and Critical Care, S. S. Institute of Medical Sciences, Davangere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).884-88

884-888

133

79

32.

PHARMACOGNOSTICAL, PHYTOCHEMICAL, HPTLC AND ETHANO-BOTANICAL STUDY OF BAUHINIA PURPUREA L. POD

Background: Bauhinia purpurea L. is a flowering plant belongs to family Leguminosae, also known as purple orchid plant. All parts of this plant including leaves, stem bark, flower and pods are edible and used for various medicinal purposes. Detailed pharmacognostic profiling of various parts has been performed except plant Pod, thus pod was selected for this study. Objective: The purpose of this w...

Nilesh Gupta, Sapna A. Kondalkar *, Mohini Arya, Vandana Bharthi, Biswajit Paul, Avinash Kondalkar and A. K. Meena

Regional Ayurvedic Research Institute, Aamkho, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).889-99

889-899

192

108

33.

DEVELOPMENT OF A VALIDATED FORCED DEGRADATION STUDY FOR CHARACTERIZATION OF CICLESONIDE DEGRADANTS USING LC-MS

The stressed degradation study of Ciclesonide was conducted using various conditions, including acid, base, photolytic, thermal, and oxidative degradation. LC-MS was employed to characterize the degradants formed during these stress conditions. To assess the stability of Ciclesonide under stress, the study followed the guidelines outlined in ICH Q1A (R2). During the analysis, a C18 column (250mm x...

Pallavi V. Duse * and Kamalkishor G. Baheti

Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy, Rauza Bagh, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).900-08

900-908

142

80

34.

PATTERN OF DRUGS PRESCRIBED FOR ELDERLY PATIENTS BY PRIVATE PRACTITIONERS OF MODERN MEDICINE IN LUCKNOW, THE CAPITAL OF UTTAR PRADESH

Changes in drug prescribing-pattern in different groups of population and age-related pathophysiological changes may result in altered response of drugs and need proper monitoring to avoid adverse consequences. Polypharmacy is very common in elderly which further increases risk for unwanted effects. Moreover, physicians should be more familiar with the common problems and diseases occurring amongs...

Rakesh Chandra Verma *, Amit Singh and Rakesh Kumar Dixit

Deppartment of Pharmacology, IMS, BHU, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).909-12

909-912

137

78

35.

DEVELOPMENT AND VALIDATION OF A METHOD FOR QUANTIFICATION OF SIPONIMOD IN SPIKED RAT PLASMA

The creation of reliable bioanalytical LC-MS (liquid chromatography-mass spectroscopy) methods is crucial for the discovery, development, and eventual marketing approval of new drugs. A brand-new medication called siponimod was developed to treat Multiple Sclerosis (MS). This medication is a sphingosine-1-phosphate (S1P) receptor modulator and is hypothesised to contribute to the reduction of MS-r...

P. Venkateswara Rao *, Biswa Mohan Sahoo and D. Sri Lakshmi

Vikas College of Pharamacy, Vissannapeta, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).913-20

913-920

151

84

36.

DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHODFOR LAFUTIDINE IN BULK AND TABLET DOSAGE FORM

A simple, precise and sensitive High Performance Liquid Chromatographic method has been developed for the quantitative estimation of Lafutidinein bulk and tablet dosage form. The method was performed on Silicagel 60 F254 aluminum plate. A Camag HPTLC system comprising of Camag Linomat IV semiautomatic sample applicator, Camag TLC Scanner 3, Camag twin-trough chamber (10×10 cm) and Camag CATS 4 so...

Vidhi Kotadiya * and Jaya Patel

Department of Quality Assurance, K. B. Raval College of Pharmacy, Kasturinagar, Shertha, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).921-25

921-925

137

91

37.

A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF OLANZAPINE VERSUS RISPERIDONE AS AN ADJUNCT TO LITHIUM CARBONATE IN PATIENTS WITH BIPOLAR AFFECTIVE DISORDER AT A TERTIARY CARE HOSPITAL

The objective of the research was to compare the efficacy and safety of Olanzapine versus Risperidone as an add-on to Lithium carbonate in patients with bipolar affective disorder. Methods: Prospective, randomized, comparative study conducted in psychiatric Department from Nov 2018 to May 2020. 80 BPAD patients who fulfilled eligibility criteria were randomized (1:1) into two groups of 40 each rec...

M. V. Venkat Raghav, P. Panchaksharimath * and Shankar

Department of Pharmacology, Bangalore Medical College & Research Institute, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).926-33

926-933

153

92

38.

FORMULATION, OPTIMIZATION AND EVALUATION OF RESVERATROL LOADED NANOEMULSION USING RESPONSE SURFACE METHODOLOGY

Phytochemicals are intensively addressed for clinical uses, and nanostructured phytochemical delivery vehicles are on the limelight. A viable potential treatment for neurological disorders is resveratrol. In the current investigation, we sought to create a nanoemulsion containing resveratrol utilising the response surface methodology. Using Neem oil, Pluronic-f 68, and Tween 80, the effects of the...

Swati D. Raysing * and Shyam W. Rangari

Department of Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karvandnaka, Shirpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).934-43

934-943

124

88

39.

VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AXITINIB AND AVELUMAB BY USING ANALYTICAL QUALITY BY DESIGN (AQbD) METHOD

The quantitative measurement of Axitinib and Avelumab has been created using a simple, quick, precise, sensitive, and reproducible reverse-phasehigh-performance liquid chromatography (RP-HPLC) method. It is more difficult to analyse varying amounts of pharmaceutical active medicinal ingredients in dose forms without any interferences. Therefore, the objective of the current work is to estimate Axi...

K. Nithiyananthan * and K. V. S. Prasada Rao

Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).944-55

944-955

157

90

40.

ESTIMATION OF TARTRAZINE IN FRUIT JUICES AND JAMS BY HPTLC METHOD DEVELOPMENT AND VALIDATION PARAMETERS

Tartrazine is a lemon-yellow synthetic food colourant belonging to azo group. The Acceptable Daily Intake (ADI) of tartrazine is 7.5mg/kg However, it is possible that more than permissible amount of Tartrazine is used to make food items more attractive. This may pose threat to consumer’s health. Hence the overall aim of the study was to detect and quantitate the presence of tartrazine in commerc...

P. Kamat, P. P. Shetti * and R. Paranjape

Department of Biotechnology, KAHER’s Dr. Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).956-61

956-961

144

80

41.

MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS IN LUMBINI PROVINCE OF NEPAL

Medication Adherence is defined as "the extent to which a person's behavior in taking medication, lifestyle management, diet, corresponding with an agreed recommendation from a healthcare provider". Hypertension also called high blood pressure is defined as persistency with an elevation in systolic blood pressure ≥140 mmHg and /or diastolic pressure ≥ 90 mmHg. A cross-sectional study was carri...

Gautam Prasad Chaudhary *, Bijay Gautam, Shristi Bauddhacharya, Bipana Bhusal, Saraswati Khatri, Mukesh Kumar Chaudhary and Ram Bahadur Khadka

Department of Pharmacy, Crimson College of Technology, Pokhara University, Pokhara, Nepal.

DOI: 10.13040/IJPSR.0975-8232.15(3).962-70

962-970

249

92

42.

OPTIMIZATION AND DEVELOPMENT OF TOPICAL METAL ION – CONTAINING ANTIBACTERIAL CREAM AND GELS

Normally and often skin infections present therapeutic challenges to practitioners and researchers due to the growing concern regarding multi-drug resistant bacterial, Viral, and Fungi Strains. The Antibacterial properties of zinc sulphate and copper sulfate are well known and have been investigated for many previous years. However, the synergistic effect between both metal ions as antibacterial i...

Ankit Singh Chauhan * and Ashvani Kumar

Institute of Pharmaceutical Sciences and Research, Unnao, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).971-98

971-978

127

92

43.

POTENTIAL ANTI-ULCER ACTIVITY OF SIDDHA POLY HERBAL FORMULATION PANCHA MOOLA KUDINEER CHOORANAM: INSIGHTS FROM MOLECULAR DOCKING

The Siddha medicine system, predominantly practiced in South India, encompasses a diverse range of medicinal formulations. Among them, Pancha Moola Kudineer Chooranam (PMKC) from the Therayar Maha Karisal literature is claimed to be effective against ulcers. Helicobacter pylori, causes gastric and duodenal ulcers through various transmission routes. It colonizes the duodenal epithelial cells, lead...

S. Yasiga * and S. Visweswaran

Department of Gunapadam, National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).979-85

979-985

139

82

44.

CLINICOPATHOGICAL SIGNIFICANCE OF SERUM PROLACTIN, CA19-9 AND C – REACTIVE PROTEIN IN COLORECTAL CANCER

The incidence of colorectal cancer in India ranks fourth in men and third in women. Carcinogenesis is a process that involves a combination of mutations in oncogenes, tumour suppressor genes or epigenetic changes in DNA such as methylation. Our study aim to assess the clinicopathogical significance of serum Prolactin, CA19-9 and C – reactive protein in colorectal cancer. Population based case co...

Padmini Shreyas Lambture * and Abdul Kayyum Shaikh

Department of Biochemistry, Ashwini Rural Medical College, Hospital & Research Centre Kumbhari, Solapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(3).986-89

986-989

111

66