Volume 1 (2010) - Issue 4, April
For cancer therapy, microtubule network is an attractive cellular target. Main component of cell cycle is mitotic stage, particularly when the mitotic spindle separates the replicated chromosomes. The rapid microtubule dynamics also play a critical role for activities of the bipolar spindle. Microtubule targeting drugs act at binding site either by destabilizing or hyper-stabilizing microtubules. ...
More than 50% of pharmaceutical products are orally administered for several Reasons and undesirable taste is one of the important formulation problems that is Encountered with such oral products. Taste of a pharmaceutical product is an important parameter governing compliance. Hence taste masking of oral Pharmaceuticals has become important tool to improve patient compliance and the Quality of tr...
Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. Structural Advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a brief review of ...
Mentha piperita, a commercially important medicinal plant, yields essential oils. The oil extracted by steam distillation, gives two types of waste products viz. high boiling hydrosol and bottom pitch, which sell at a very low price. Some constituents of the waste products are useful in perfumery industry and they also exhibit medicinal activities such as anti-inflammatory. The aim of present stud...
COMPARISON OF DIFFERENT SUPERDISINTEGRANTS IN DESIGNING OF FAST DISSOLVING TABLETS OF METOPROLOL TARTRATE
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Th...
Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. In the present ...
Ofloxacin is a fluoroquinolone antibiotic considered to be a second-generation fluoroquinolone. Ofloxacin is administered by oral, intravenous or topical (eye and ear drop) route. It is used as antibacterial for the treatment of various diseases like chronic bronchitis, pneumonia, urethritis, cervicitis, urinary tract infections, prostatitis, uncomplicated urethral and cervical gonorrhea. Ofloxaci...
Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indic...
In present study, in vitro methods were selected to test and compare the antioxidant activity at different levels involving formation and scavenging of free radical by extract of Butea monosperma flowers (EBMF). The total phenolic content of EBMF was found to be 19.09 mg (equivalent to gallic acid) per gram of extract. In addition, reducing power was found to be increase with the increasing concen...
The study is aimed at development of Physico-chemical parameters and to investigate the active principle present in Chlorophytum borivilianum. Chlorophytum borivilianum San. and Fern. (Liliaceae) commonly known as Safed Musli is an important plant used against various disorders in indigenous systems of medicine, such as antioxidant, analgesic, and as a remedy for male impotence and to boost the i...
Ketoprofen is a non-steroidal anti-inflammatory drug. Glucopyranoside Conjugates of Ketoprofen have been synthesized and evaluated for anti- inflammatory, analgesic and ulcerogenic activities. In vivo biological screening in mice and rats indicated that conjugates improved analgesic and anti-inflammatory activities with significantly reduced ulcerogenicity compared to the parent drug....
HEPATOPROTECTIVE ACTIVITY OF SACHHARUM OFFICINARUM AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
The hepatoprotective activity of juice of Saccharum officinarum was investigated against paracetamol (acetaminophen) induced liver damage in rats. Paracetamol (PCM) is analgesic, antipyretics drugs available as an over the counter (OTC) medication which cause hepatotoxicity as higher doses. Paracetamol at 3gm/kg induced liver damage in rats manifested by statically increased serum alanine aminotra...