Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
DETERMINATION OF ELEMENTAL IMPURITIES IN ESLICARBAZEPINE ACETATE A PARTIAL SEIZURE DRUG BY USING ICP-MS
Eslicarbazepine acetate is a chemical compound that has found medical use as a partial seizure drug. Monitoring of heavy metals (As, Mn, Cd, Cr, V, Mo, Cu, and Sb) in-process, intermediates, and final drug substances is an important activity in the pharmaceutical industry because of the potential for toxicity and the risk of serious health hazards even at very low doses. This research article esta...
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AN IN-SILICO APPROACH FOR DESIGNING POTENTIAL ANTAGONISTIC MOLECULES TARGETING CYCLIN-DEPENDENT KINASE HAVING THERAPEUTIC SIGNIFICANCE IN CANCER
Cancer is a preminent cause of death worldwide after heart disease. Although there are many types of cancer treatments, depending on the type of cancer and its stages, due to their complexity and adverse cytotoxic effects, some novel targets at the molecular level that are cancer-specific have become the area of research for more than a decade. Some targets have been identified, and CDKs are among...
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DESIGN AND DEVELOPMENT OF MODIFIED RELEASE DOSAGE FORM OF BCS CLASS-III DRUG BY NOVEL PASTILLATION TECHNIQUE
The primary goal of this study was to evaluate solid lipids as an alternative to polymers in the formulation of oral modified-release pastilles. Lipids have been used in pharmaceuticals since ancient times for a variety of purposes. They are used as polymer substitutes in the development of dosage forms. The solvent-free technique of pastillation uses lipids to formulate a modified-release oral do...
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MOLECULAR DOCKING ANALYSIS OF SESQUITERPENES WITH ANTI-APOPTOTIC PROTEIN (BCL-2 AND BCL-XL) AND PREDICTING THEIR PHYSICOCHEMICAL PROPERTIES
One of the main causes of mortality around the globe is cancer. Cell division routes increase as cancer progresses, but planned cell death decreases. As a result, cancer is characterized by a variety of these failing systems. The present study used an in-silico approach to examine the ability of sesquiterpene lactones to inhibit the anti-apoptotic proteins Bcl-2 and Bcl-xl. Numerous Bcl-2 inhibito...
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IN-SILICO STUDIES ON CHEMICAL CONSTITUENTS OF CALOTROPIS SPECIES
Nowadays, the use of herbal drugs is tremendously increased due to the lesser number of side effects when compared to pure form of drugs. Herbal medicine is a complex compound with multiple synergistic mechanisms of action which modulate pathophysiological functions. Even though few herbs exhibit toxicity, they possess many therapeutic values and curative principles; one such herb is calotropis. I...
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SYNTHESIS, MOLECULAR DOCKING, SAR AND BIOLOGICAL ACTIVITIES OF NOVEL THIAZOLIDINE-4-ONE-PYRAZOLE HYBRIDS
A series of novel thiazolidine-4-one-pyrazole hybrids (4a-4j) had been synthesized by Claisen-Schmidt condensation, Schiff’s base, and Cyclization mechanism. The newly synthesized target molecule structures were confirmed by IR, 1H NMR and Mass spectral data. The synthesized hybrids were screened for in-vitro anticancer and anthelmintic activities. The anticancer activity was assessed using MTT ...
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HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC DETERMINATION OF PARACETAMOL, DICLOFENAC, AND CAFFEINEIN COMBINED TABLET DOSAGE FORM
A new simple High-Performance Thin Layer Chromato-graphic (HPTLC) method for determining Paracetamol, Diclofenac and Caffeine in combined tablet dosage form has been developed and validated. The mobile phase selected was Ethyl acetate: Methanol: ammonia (8: 2:0.1 v/v/v) with UV detection at 263 nm. The retention factor for Paracetamol, Diclofenac, and caffeine was found to be 0.639 ± 0.018, 0.267...
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INFLUENCE OF STACHYDRINE ON IMMUNOMODULATION IN MICE
The Present study was planned to gauge the immune-modulatory activity of the ethanolic extract and the isolated compound Stachydrine from the leaves of Capparis sepiaria L. (Capparidaceae). The study was extended to research the chemical compounds within the EECS (Ethanolic Extract of Capparis sepiaria). The preliminary phytochemical screening revealed that EECS evidenced the presence of varied ph...
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KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19 AMONG MEDICAL UNDERGRADUATE STUDENTS FROM WESTERN INDIA: A CROSS SECTION STUDY
Background: An emerging respiratory disease was abbreviated as COVID 19, after it has been first reported in December 2019 in Wuhan city of China. The major route of transmission of COVID-19 is droplet and close contact. Government of India has initiated training for health care workers at a different level. WHO and CDC also initiated a multidisciplinary approach to tackle COVID-19 of which awaren...
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A RETROSPECTIVE OBSERVATIONAL STUDY TO ASSESS THE CLINICAL MANIFESTATIONS AND FUNCTIONING STATUS AMONG COVID-19 SURVIVORS WITH AND WITHOUT POST-COVID SYNDROME
Post-COVID syndrome is defined as COVID-19 associated illness that extends for more than three weeks from the onset of symptoms, and chronic COVID-19 is an illness that extends beyond 12 weeks from the onset of symptoms. An online survey was conducted where 400 Covid-19 infected, participated from various areas of India. Among 400, 58% (232) had complaints of persistence of Covid symptoms. The mos...
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