TOLERANCE STUDY OF “SPIRULINE PLUS” AND EVOLUTION OF BIOLOGICAL PARAMETERS IN PEOPLE LIVING WITH HIV-1 FOR TWELVE MONTHS
Spirulina is an algae used in our country for people living with HIV (PLHIV) and it is known especially for its therapeutic immunostimulatory effects. Spirulina capsules produced locally enriched in zinc and selenium called "spiruline plus" were formulated and given to PLHIV. The objectives of this randomized placebo controlled trial were to assess the tolerance by reporting side effects and t...
RESPONSES OR EFFECT OF CEREBRAL MALARIA ON PLATELET COUNT, PLATELET FACTOR – 3 AND PLATELET AGGREGATE AVAILABILITY IN CHILDREN
Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function’s role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and...
The approval of first-in-class proteasome inhibitor bortezomib in 2003, made possible the therapeutic validation of proteasome as a target for use in discovery and development of new treatment options in cancer, particularly haematological conditions like Multiple Myeloma. However, this breakthrough drug discovery suffered from a few limitations. As a result, the discovery of bortezomib not only i...
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expres...
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes,...
FORMULATION, EVALUATION AND ESTIMATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE CONVENTIONAL TABLETS IN COMBINED DOSAGE FORM AND ITS COMPARISON WITH MARKETED FORMULATIONS
Oral route of drug administration have wide acceptance up to 50-60% of total dosage forms. Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly the patient compliance. This study was aimed at development of Propranolol hydrochloride and flunarizine dihydrochloride conventional dissolving tablets in combined dosage f...
SHORT-TERM TREATMENT OF ELASTASE-LPS INDUCED EXACERBATION MODEL OF EMPHYSEMA IN MICE WITH DOCOSAHEXAENOIC ACID, A PRECURSOR OF ANTI-INFLAMMATORY AUTACOIDS
An essential pathological phenotype of chronic obstructive pulmonary disease is emphysema or lung tissue destruction. The study aims to assess docosahexaenoic acid (DHA), a precursor for specialized pro-resolving mediators, as a treatment of emphysema. Albino mice were challenged with porcine pancreatic elastase on day 1 and bacterial lipopolysaccharide on day 21 to induce emphysema. The pathologi...
Natural products have great potential against microbes and can be used to overcome the problem of drug resistant pathogens. They are helpful in reducing the toxicity of existing antifungal compounds. This present in vitro study demonstrated the synergistic effectiveness of Cassia fistula (CF) leaves extracts and fluconazole (Flu) against isolated Flu resistant strains (FRSs) of Candida albicans (C...
Neurodegeneration accounts for diseases like Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, etc. that come under neurodegenerative diseases. Parkinson’s disease is the second most common neurodegenerative disease. The main hallmarks of Parkinson’s disease are progressive loss of motor control and cognitive dysfunction. Current treatments are of reducing the symptoms, do ...
Aim and Objectives: To study the analgesic activity of telmisartan in graded doses, in tail flick method and acetic acid induced writhing method in rats and mice respectively. Materials and Methods: Analgesic activity of telmisartan was evaluated in graded doses tail flick model (for central action) and acetic acid induced writhing model (for peripheral action) of analgesia. Aspirin & tramad...