PHARMACOPHORE BASED MODELLING OF PYRIDINE-PYRIMIDINE ANALOGS AS MER TYROSINE KINASES INHIBITORS IN ANTICANCER THERAPY
MER kinase is an important tyrosine-kinase receptor that is associated with a variety of cancers, including mantle cell lymphomas, pituitary adenomas and T-cell acute lymphoblastic leukemia. Identification of new MERTK inhibitors assumes crucial importance. Only one ligand-based pharmacophore model is reported to date for MERTK inhibitors. There are many more molecules with improved enzyme inhibit...
Background and purpose of the study: Propranolol hydro-chloride beta-adrenergic receptor antagonist utilized in the treatment of high blood pressure, atrial fibrillation, myocardial infarction, angina and migraine headaches. The pharmacokinetic parameters make Propranolol hydrochloride an appropriate candidate for oral disintegrating tablets. This work aims to develop orally disintegrating tablets...
Antimicrobial activity of the various species of Hibiscus like Hibiscus sabdariff, Hibiscus rosa-sinensis, Hibiscus trionum, Hibiscus cannabinus, Hibiscus mutabilis against various pathogens like Staphylococcus aureus, E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, Serratia marcescens, were studied with the help of agar well...
AN OPTIMIZED HERBAL FORMULA DIMINISHES CCL4-INDUCED HEPATOTOXICITY IN RATS BY INHIBITION OF LIPID PEROXIDATION AND P53-MEDIATED APOPTOSIS
Introduction: In this present study, the heaptoprotective effect of an optimized herbal formula (HF) was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. Methods: In-vitro antioxidant activity of the HF was evaluated by reducing power, lipid peroxidation, and DPPH scavenging assays. Hepatoprotective activity of HF (100, 200 and 400 mg/kg b.w) was evaluated against CCl4...
A SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVEMENT IN ORAL BIOAVAILABILITY OF NIMODIPINE: IN-VIVO EVALUATION
The current research involves the study of a Nimodipine self-nanoemulsifying drug delivery system (SNEDDS) with improved bioavailability and solubility. Fifteen formulations of Nimodipine SNEDDS were prepared prior to evaluation of particle size, emulsification time, percentage drug release, percentage transmittance, thermodynamic stability and in-vitro drug release. The formulation F13 was chosen...
FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN FOR SOLUBILITY ENHANCEMENT BY QUALITY BY DESIGN APPROACH
Rosuvastatin is an antihyperlipidemic agent belonging to BCS class II Drugs with low aqueous solubility and high permeability. Objective: To formulate Rosuvastatin nanosuspension by Emulsification solvent diffusion technique by QbD approach and its evaluation. A 2² factorial design was employed to study the effect of independent variables [SLS (X1) and amount of PVP K -30(X2)] and dependent varia...
QUANTITATIVE AND QUALITATIVE PHYTOCHEMICAL ANALYSIS IN BARK OF NOTHOPEGIA RACEMOSA (DALZ.) RAMAM. COLLECTED FROM GADIKALLU, SHIMOGGA, KARNATAKA
Plants are a source of bioactive compounds produced by different parts of the plant, maybe bark, leaves, flowers, roots, fruits, and seeds, during metabolic activities. These secondary metabolites may have protective and disease preventive properties, hence used by Traditional practioner to treat various ailments. Most plants of the Western Ghats of India remain unknown, poorly understood or unest...
Introduction: Drug-resistant tuberculosis (DR-TB) emerged from the time anti-tuberculosis drugs were discovered and used. It has become a formidable obstacle in the eradication of tuberculosis. India is in second position after China with tuberculosis, where about 20% of patients with DR-TB were not treated due to inappropriate coordination and diagnostic facilities. Method and Materials: A retros...
Most lipids used in solubilizing poorly soluble drugs are synthetic or semi-synthetic. In this study, the African Baobab seed oil (natural oil) was investigated for its potential in solubilizing poorly soluble drugs in a microemulsion formulation. Oil was extracted from untreated seeds by hydraulic pressing. Physicochemical characteristics of the oil were determined. The solubility of Furosemide, ...
DEVELOPMENT AND VALIDATION OF TLC-DENSITOMETRIC METHOD FOR ESTIMATION OF FLUPIRTINE MALEATE AND ITS FORMULATIONS
A simple, precise, accurate, and reliable high-performance thin-layer chromatographic method has been developed and validated for the analysis of flupirtine maleate in capsule dosage form. Identification and analysis were performed on 10 cm × 10 cm layer thickness 0.2 mm, precoated silica gel G60-F254 aluminum sheet, prewashed with methanol, and dried in an oven at 50 °C for 5 min. Ethyl acetate...