IN-VITRO STUDY OF ANTI-DIABETIC, ANTI-CANCER AND ANTI-UROLITHIATIC ACTIVITY OF DIFFERENT EXTRACTS OF PROSOPIS JULIFLORA SEEDS
Plants and their parts are used to treat many infectious diseases due to the presence of phytoconstituents and avoid some side effects. The present study evaluated the phytochemicals, anti-diabetic, anti-urolithiatic, and anti-cancer activities of Prosopis juliflora seeds in various solvents such as aqueous, ethanol, and 85% ethanol. The preliminary works revealed the presence of secondary metabol...
HISTOLOGICAL ALTERATIONS IN THE TESTES OF GAMMA-IRRADIATED MICE INDUCED BY ADHATODA VASICA LEAF EXTRACT
Extract of Adhatoda vasica leaves has been used to treat various diseases and disorders in Ayurvedic and Unani medicine. Effect of ethanolic extract of Adhatoda vasica against gamma radiation-induced changes in terms of histological alterations in testes of Swiss albino mice were studied at post-irradiation intervals between 1-30 days. Mice exposed to 6 Gy gamma radiation showed radiation-induced ...
QUANTITATIVE ESTIMATION OF MINERAL CONTENT FROM EDIBLE FLOWERS OF ALLIUM CEPA, CUCURBITA MAXIMA AND CARICA PAPAYA: A COMPARATIVE STUDY
Edible flowers have been an integral part of human nutrition for centuries, being used as garnishes of individual dishes and also consumed fresh. This study determines and compares the essential and trace mineral composition of the three edible flowers of Allium cepa (onion), Carica papaya (papaya) and Cucurbita maxima (pumpkin) with four other commonly consumed edible flowers. Also, a comparative...
Parkinson's disease is a chronic progressive neuro-degenerative disease caused by selective degeneration of dopaminergic neurons in the dense part of the substantia nigra pars compacta. It is characterized by motor and non-motor symptoms, especially the gradual reduction of postural symptoms, instability, tremor and memory impairment, local neuron loss, which mainly occurs in the substantia nigra....
EVALUATION OF ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF CAPPARIS MOONII WIGHT FRUITS IN SWISS ALBINO MICE
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmacological activity of Ethanolic extract of Capparis moonii Wight. The analgesic activity was examined by Eddy's hot plate method and the acetic acid-induced writhing method. In Eddy’s Hot plate method, after o...
CORRELATION OF ANTIOXIDANT, ANTIBACTERIAL AND PHYTOCHEMICALS OF LEAVES AND ROOTS EXTRACTS OF CLERODENDRUM INFORTUNATUM
The leaves and roots extracts of Clerodendrum infortunatum was evaluated for its potential antioxidant and antibacterial properties. The correlation studies with phytochemicals were performed, which has not been widely reported yet. Clerodendrum infortunatum leaves and roots were screened for the presence of phytochemicals and were found positive for carbohydrates, saponins, alkaloids, tannins, ph...
Embelin was one of active constituents of Embelia ribes Burm. f. Embelin has been reported to possess many pharmacological effects. The studies as was perform to enhance the bioavailability of poorly water soluble embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT. For this, phytosome, a novel drug delivery system, was adopted. Total six Embelin loaded phytosome com...
FORMULATIONS AND STANDARDIZATION OF THE AQUEOUS EXTRACT FROM THE LEAVES OF MORINDA LUCIDA BENTH, A HYPOGLYCEMATING PLANT
With a view to enhancing endogenous knowledge about plants, the present study has been aimed at developing and standardizing dosage forms based on the aqueous extract of Morinda lucida Benth, a plant with hypoglycaemic anti-hyperglycaemic properties. After the aqueous extraction of the leaves of this plant, by maceration, phytochemical screening was carried out on a TLC plate by using the method o...
The discovery of alternative medications in diabetes management is of huge importance to achieve better safety and efficacy. The natural antioxidant and carbohydrate hydrolyzing enzyme inhibitors are gaining too much importance in the management of diabetes. Lack of scientific data is available on antioxidant and antidiabetic activities on root extract of Spermadicyton suaveolens. Therefore, we ai...
EFFECT OF ANTI-DIABETIC DRUGS ON SERUM B12, MINERALS LIKE ZINC, MAGNESIUM, PHOSPHORUS AND CALCIUM IN TYPE II DIABETES MELLITUS (T2DM)
Metformin, the first-line drug, can reduce hepatic gluconeogenesis and increase insulin sensitivity. At the molecular level, metformin inhibits the mitochondrial respiratory chain, which leads to an increase in adenosine monophosphate-activated protein kinase, which increases insulin sensitivity. Recent guidelines advocate metformin as the first-line agent that has a glucose-lowering effect concur...