Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
DEVELOPMENT AND EVALUATION OF HP-β-CD COMPLEXATION BASED NOVEL OPHTHALMIC GEL FORMULATION OF NEPAFENAC
Nepafenac is an analgesic and anti-inflammatory drug, used in post-operative ocular pain and presently available in the market in the form of 0.1% ophthalmic suspension eye drop due to aqueous insolubility of the drug. The present formulation is not only poor patient compliant due to suspension form but also suffers from a short corneal residence and inadequate ocular bioavailability. The objectiv...
4399
852
PTEN-A REVIEW
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general ph...
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835
PREPARATION AND CHARACTERIZATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS
Atenolol is a hypertension drug that has a low solubility characteristic in water and gastric fluid. The rate of absorption of the drug with poor solubility characteristics is determined by the dissolution process. In this study, an attempt has been conducted to increase the dissolution of atenolol by increasing its solubility. The solubility of atenolol has been enhanced by the inclusion complex ...
5608
1433
A VALIDATED LC-MS/MS BIOANALYTICAL METHOD FOR THE SIMULTANEOUS DETERMINATION OF THREE ACE-INHIBITORS IN HUMAN PLASMA
A selective and rapid LC-MS/MS spectrophotometric method has been developed and validated for the simultaneous determination of three ACE-inhibitors used in anti-hypertensive therapy, namely enalapril maleate, perindopril, and ramipril in human plasma using high-performance liquid chromatography-tandem mass spectrophotometry (LC-MS/MS) with electrospray ionization (ESI). Separation of analytes and...
3025
1138
DEVELOPMENT AND CHARACTERIZATION OF ANTI-DANDRUFF NIOSOMAL HAIR GEL CONTAINING TEA TREE OIL
Dandruff is the excessive shedding of dead skin cells from the scalp, apparently caused by a fungus called Malassezia restricta and M. globosa. Malassezia formerly called Pityrosporum is a yeast causing infection of skin and scalp. Tea tree oil (TTO) is an essential oil that is obtained by steam distillation of the leaves and terminal branches of Melaleuca alternifolia (Myrtales: Myrtaceae). Tea t...
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PHARMACOGNOSTICAL STANDARDIZATION OF PLANT CRYPTOLEPIS BUCHANANI ROEM. & SCHULT. AERIAL PART
Cryptolepis buchanani Roem. & Schult. (Family: Asclepiadaceae) commonly-known as Wax leaved climber, Kali Sariva in English and Sanskrit. It is broadly used in Ayurveda as a remedy of ailment. Though, its diverse medicinal aspects, no detail pharmacognostical study is available till date. The present study is to investigate the pharmacognostical characteristics of C. buchanani aerial part. The...
2751
1225
DEVELOPMENT OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDE
The aim of the present study was to formulate an osmotically controlled drug delivery system (O-CDDS) of Metformin hydrochloride to reduce the frequency of multiple dosing in non-insulin dependent diabetes mellitus-II which is a lifelong disease. Metformin hydrochloride a BCS Class-III drug having a poor biological half-life of 6 h. O-CDDS of Metformin hydrochloride is a recent approach for the ze...
2396
1022
STABILITY INDICATING ASSAY FOR DILTIAZEM AND ITS METABOLITES IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY FOR PHARMACOKINETIC APPLICATION
A simple and sensitive Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry method was developed to perform a stability study of diltiazem and its metabolites in human plasma using various buffer reagents at a different strength. The method was applied for the quantification of diltiazem and its two major metabolites N-desmethyl diltiazem and desacetyl diltiazem in human plasma. The an...
2013
1101
VALIDATED STABILITY INDICATING HPTLC METHOD FOR PROTOCATECHUIC ACID
Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid, commonly found in bran, grain, brown rice, fruits such as plums, gooseberries, grapes and also in onion peels. A new, simple, precise, accurate and sensitive stability-indicating HPTLC method for Protocatechuic acid was successfully developed. This method is based on HPTLC separation followed by UV detecti...
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783
DESIGN AND SYNTHESIS OF NOVEL HYDRAZONES OF ETHYL3-AMINO-4-HYDROXYBENZOATE AS PROMISING ANTICONVULSANT AGENTS
A series of hydrazide-hydrazones (3a-o) have been synthesized by the reaction of acid hydrazide (2) which is obtained from 4-carbomethoxy-2-aminophenol with aromatic acid through multi-steps. The bioactivities of the final compounds were tested with MES and scPTZ methods. The CNS toxicity was studied by the rotarod experiment. Based on the results, compounds 3d and 3o were found to be most active ...
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