FORMULATION, OPTIMIZATION AND EVALUATION OF GLIMEPIRIDE TRANSFERO-SOMAL GEL FOR ANTIDIABETIC ACTIVITY IN RATS
Transferosomes are a special liposome type consisting of phosphatidylcholine and an edge activator. Glimepiride is a second-generation sulphonylurea exerting its effects in patients with type II Diabetes. Glimepiride is hydrophobic in nature possess less solubility and permeability. The study aims to formulate, optimize and evaluate Glimepiride Transferosomal gel for antidiabetic activity in Rats....
EVALUATION OF THE ANTIHYPERTENSIVE ACTIVITY OF R-(+)-PULEGONE IN L-NAME INDUCED HYPERTENSIVE WISTAR RATS
Objectives: The present study was aimed to assess the anti-hypertensive effect of PLG in L-NAME-induced hypertensive rats. Methods: Wistar rats of 200-240g were given L-NAME (40 mg/kg body weight/day/p.o.) in drinking water daily for 4 weeks to induce hypertension. Rats were randomly divided into six groups: control, L-NAME control, Verapamil (20 mg/kg, p.o.), and PLG (5, 10, and 20 mg/kg, p.o.)...
EFFICACY OF IVERMECTIN AND DOXYCYCLINE AS AN ADJUNCT TO REMDESIVIR IN SEVERE COVID-19 CASES – A RETROSPECTIVE ANALYSIS
Introduction: Covid-19 pandemic has posed new challenges to humanity. The definitive cure is yet to be found, while drug repurposing holds the key so far. Remdesivir had been used for the treatment of novel corona-virus. Ivermectin and Doxycycline have also been recommended for treating Covid-19, but their efficacy has not been studied extensively. Methods: We conducted a retrospective study durin...
Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the ...
PREPARATION AND CHARACTERISATION OF LORNOXICAM LOADED TRANS-FEROSOME: A NOVEL CARRIER FOR ENHANCED TRANSDERMAL DELIVERY
To study and investigate transfersomes as a transdermal delivery system for the poorly soluble drug, Lornoxicam-loaded transfersomes were prepared with non-ionic surfactants like span 80 and tween 80 by the rotary evaporation-sonication method. Drug & polymer was dissolved in an organic solvent mixture of chloroform and ethanol (1:1, v/v). The outcome of the work is that prepared formulations ...
PHYTOCHEMICAL AND PHARMACOGNOSTICAL SCREENING OF JASMINUM MULTIFLORUM (BURM. F.) AND JASMINUM MESNYI (HANCE) STEMS
Jasminum multiflorum and Jasminum mesnyi, the ornamental shrubs belonging to family Oleaceae are widely distributed throughout India. Despite their use in the essence industry for making perfumes, oils, and creams, these species are also used in the healing wounds and ulcers, constipation, flatulence, skin diseases, rheumatism, stomatitis, diabetes, stress, antiseptic, diuretics, and gastric distu...
QUALITY BY DESIGN (QBD) APPROACH TO DEVELOP STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR BILASTINE AND MONTELUKAST
Background and Objectives: As per requisition of current regulatory requirements, the simple, rapid and sensitive method by 33 factorial QbD approach was established and validated for Bilastine (BST) and Montelukast (MNT) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per Inte...
IN-VITRO AND IN-VIVO NEUTRALIZING POTENTIAL OF RAUVOLFIA SERPENTINA ROOT EXTRACT AGAINST BUNGARUS CAERULEUS VENOM
Snakebite is an international health hazard that needs attention in terms of effective management and better treatment to recover the health of the affected individuals and society. Tribal populations and folk therapists across the world have been using innumerable plants to treat snakebite difficulties. In the present study, the efficacy of aqueous extracts of Rauvolfia serpentina root for neutra...
COMBATING THE EMERGING DRUG-RESISTANT PSEUDOMONAS AERUGINOSA BY AN ANTIBIOTIC PURIFIED FROM THE NOVEL STREPTOMYCES VIOLASCENS STRAIN VS
Aim: The emergence of drug-resistant pathogens enforces the isolation of potent and novel antibiotic-producing Streptomyces sp., from the undisclosed ecological niches. Methodology: Unique Streptomyces violascens strain VS isolated by serial dilution agar plate method and strain confirmed by 16S rDNA sequencing. Antibacterial assay against multidrug resistant Pseudomonas aeruginosa isolated from b...
ULTRA DILUTED ARSENIC-INDUCED ALTERED CYTOKINE GENE EXPRESSIONS IN EMBRYONATED EGGS CHALLENGED WITH SARS-COV-2 SPIKE PROTEIN RBD ANTIGEN
Introduction / Objective: In this study, we aimed to elucidate the action of ultra-diluted (potency 6CH as per homeopathic pharmacopeia) ethanolic extract of Arsenicum album (Arsenic 6CH) on cytokine gene expression changes along with alteration of hepatic histology in Gallus gallus embryo (embryonated egg) challenged with the spike protein (S protein RBD of Delta SARS-CoV-2). Methods: Allantoic f...