Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
A REVIEW OF BREAST CANCER AND HORMONAL THERAPY
Breast cancer is a malignant tumor that develops from ductal and lobular cells of the breast. It is the most commonly occurring female cancer in the world. After cervical cancer, breast cancer is the second most common cancer in India. Several factors are known to affect the risk of breast cancer. There is mainly two types of breast cancer: ductal and lobular carcinoma. Estrogen, directly and indi...
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SYNTHESIS OF PARACETAMOL-PEG PRODRUGS, IN-VITRO AND IN-VIVO EVALUATION
Paracetamol is a well-known drug for its antipyretic, analgesic and anti-inflammatory activity. The drug being an OTC had been used more frequently than required. As a result of this overdosage of the drug caused a hepatotoxic effect. So to overcome this, an approach of PEGylation was chosen. PEG 1500-Paracetamol, PEG 6000-Paracetamol, PEG 1500-Glycine-Paracetamol, and PEG 6000-Glycine- Paracetamo...
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IN-VITRO AND IN-VIVO EFFICACY OF ROOT EXTRACT OF LAWSONIA INERMIS AGAINST INFLAMMATORY PARADIGM
The study was carried out to evaluate anti-inflammatory activity of alcoholic extract of roots of Lawsonia Inermis (LILAC). In-vitro anti-inflammatory activity was evaluated by Cyclooxygenase inhibitory assay wherein the LIALC showed a dose-dependent inhibition of both the enzymes with IC50 values of 58.2 μg/ml for COX-1 and 7.38 μg/ml for COX-2. In RBC membrane stabilization activity, LILAC at ...
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EVALUATION OF MUSCLE RELAXANT AND LOCOMOTOR ACTIVITIES OF MALPIGHIA EMARGINATA AND HOLOPTELIA INTEGRIFOLIA
The present study was designed to evaluate the muscle relaxant and locomotor activities of petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extracts of Malpighia emarginata (ME) and Holoptelia integrifolia (HI). The different concentrations were used to evaluate the toxicity in rats and revealed that they are nontoxic up to 2000 mg/kg. From the toxicity study, 200 and 400 mg/kg doses w...
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A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ANTI-VIRAL CLASS OF ELBASVIR AND GRAZOPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: To develop accurate, precise stability indicating a method for simultaneous estimation of Elbasvir and Grazoprevir in bulk and pharmaceutical dosage form. Materials and Methods: Simple, rapid, precise, sensitive and reproducible validated stability-indicating Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative analysis of Elbasvir and Grazoprevir i...
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EVALUATION OF THE WOUND HEALING PROPERTIES OF MIMOSA PUDICA LINN. IN STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS
Mimosa pudica Linn. (Fabaceae) It is traditionally used to treat wounds and diabetes mellitus. The study was designed to evaluate the wound healing properties of ethyl acetate and ethanolic extracts of seeds of Mimosa pudica in streptozotocin-induced diabetes mellitus in rats at dose levels of 100, 200 and 400 mg/kg body weight. Both extracts decrease the fasting blood glucose in a dose-dependent ...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
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EFFECT OF MARINE BROWN ALGA LOBOPHORA VARIEGATA (J.V. LAMOUROUX) WOMERSLEY EX E. C. OLIVEIR VARIOUS SOLVENTS EXTRACTS ON DERMATOPHYTES
We here in the report the investigation of the antifungal activity of various solvent extracts obtained from a marine brown alga, Lobophora variegata against three fungal dermatophytes, namely Candida albicans, Candida tropicalis, Trichophyton mentagrophytes and a nondermatophyte Aspergillus flavus using disc diffusion method. Among the solvent extracts tested in the investigation, only the methan...
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EVALUATION OF METHANOLIC EXTRACT OF CHYTRANTHUS MACROBOTRYS SEED (CMS) FOR ANTIMICROBIAL, α-GLUCOSIDASE AND α-AMYLASE INHIBITORY ACTIVITIES
Chytranthus macrobotrys (Sapindaceae) is one of the notable African medicinal plants with traditional history but lack scientific data. This report was aimed to evaluate C. macrobotrys seed (CMS) methanol extract for its phytochemical composition, antimicrobial activity, α-glucosidase, and α-amylase inhibitory activities. Methanolic extract of C. macrobotrys seed was investigated for its chemica...
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DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL -2- (5-(1H-INDOL-3-YL)- 1, 3, 4-THIADIAZOL -2 -YLIMINO) -5 -(SUBSTITUTED BENZYLIDENE) THIAZOLIDIN-4-ONE ANALOGUES
A series of novel analogues of 2-(5-(1H-indol-3-yl)-1, 3, 4-thiadiazol-2-ylimino)- 5- (substituted benzylidene)thiazolidine-4-one have been synthesized. The structures of newly synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and Mass spectroscopy. The synthesized compounds showed significant antibacterial activity against gram-positive bacteria: Staphylococcus aureus (MTCC 3160), Ba...
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