Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
BIOTHERAPEUTICS AS DRUGS, ITS DELIVERY ROUTES AND IMPORTANCE OF NOVEL CARRIERS IN BIOTHERAPEUTICS
Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has...
2048
1243
SMARTPHONE IS IT “BEHAVIOUR ADDICTION OR SUBSTANCE ABUSE DISORDER”: A REVIEW TO FIND CHEMISTRY BEHIND
Several behavioral addictions have been hypothesized as having similarities to substance abuse addictions. The DSM-4-TR has designated formal diagnostic criteria for several addictive disorders classifying them as impulse control disorders, a separate category from substance use disorder. There have been a lot of behavioral addiction studies like tanning, cosmetic surgery, sexual addiction, etc....
2929
1448
ROLE OF POLYMERS IN SUSTAINED RELEASED MICROBEADS FORMULATION: A REVIEW
The aim of this article is to provide a wide-angle prospect of the detailed information of pharmaceutical polymers in sustained released micro-beads dosage forms. Polymers have played an integral role in the advanced drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and constant release of both hydrophilic and hydroph...
1966
912
GENETIC BACKGROUND ASSOCIATED WITH THE PROGRESSION OF NON- ALCOHOLIC FATTY LIVER DISEASE TO LIVER FIBROSIS
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAF...
1063
646
FORMULATION OF MICRO BEADS: A REVIEW
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration. This could be achieved through multiparticulate dosage form like beads which are divided into many individual units, so, called subunits, each exhibiting some desired characteristics. Micro particulate drug delivery systems ...
4124
2218
CANDIDATURE OF THE SYNTHETIC CASPASE INHIBITORS AS NEW ANTI-SARS-COV-2 DRUG DISCOVERY, IN-SILICO MOLECULAR DOCKING
The new pandemic virus identified as severe acute respiratory syndrome Coronavirus 2 is the etiological agent responsible for the pneumonia outbreak that ended with respiratory failure. The main protease (MPRO) is a key enzyme for SARS-CoV-2, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we determine the mech...
2655
2283
DESIGN, DEVELOPMENT AND SYNTHESIS OF NOVEL CHIRAL DERIVED MOLECULES, POTENTIALLY ACT AS RNA POLYMERASE NSP-12 AND NSP-6/10 COMPLEX INHIBITORS AGAINST COVID-19
Novel Di and Tridentate chiral molecules and its analogues were designed and synthesized in that the chiral amino ester and 2-amino-3, 5-dibromobenzaldhehyde were condensed. Further, it has coupled with Cassic acid to form desired active molecules. The developed compounds are evaluated for molecular docking to check potency and may represent potential drug candidate inhibitors of RNA dependent RNA...
1735
1206
IN-SILICO BINDING AFFINITIES OF ALKALOID COMPOUNDS ON NICOTINIC ACETYLCHOLINE RECEPTOR α3β4 FOR SMOKING CESSATION TREATMENT
Nicotinic acetylcholine receptor α3β4 is considered as a potential target for anti-smoking drug discovery. In this study, in-silico approaches, including molecular docking and molecular dynamics simulation were applied to investigate binding affinities of 300 alkaloids into the α3β4 (Pdb id: 6PV8). The docking results showed that most of the alkaloids fitted well into the binding pocket of α3...
2792
1080
PROTECTIVE ROLE OF MELATONIN AND TAURINE AGAINST TOXICITY INDUCED BY CAFFEINE IN BRAIN BY ABROGATION OF OXIDATIVE STRESS, DECREASE APOPTOSIS, AND ALTERS CEREBRAL MONOAMINE NEUROTRANSMITTERS IN MALE ALBINO RATS
The current study aimed to investigate the protective effects of taurine and melatonin against caffeine-induced brain damage in rats. 36 male albino rats were divided into 6 groups: Group I: control, group II: Rats received 20 mg/kg melatonin for 28 days. Group III: Rats received 50 mg/kg taurine dissolved in distilled water daily for 28 days. Group IV: Rats received 50 mg/kg caffeine dissolved in...
2206
1149
PHYTOCHEMICAL INVESTIGATION, ANTIOXIDANT AND CYTOTOXIC ACTIVITY STUDIES OF ROOT BARK EXTRACTS OF ARTOCARPUS HETEROPHYLLUS LAM.
Plant drugs enjoy much acclaim and worldwide acceptability even in the midst of amazing advancements in modern medicine. Current research in drug discovery from medicinal plants involves an approach combining botanical, phytochemical, and pharmacological techniques. In the present study, we selected the root bark of the plant Artocarpus heterophyllus Lam. belonging to the family Moraceae, to estab...
1928
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