Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
EFFECTS OF TRADITIONAL FORMULATIONS ON EXTRA GASTRIC MUCUS OF RATS
According to Iranian traditional Medicine (ITM) “Monzej” es are applied to mature and eliminate abnormal humor, correct the abnormal temperament and promote the formation of normal humor, restoring the functions of all organs and the natural body force. “Monzej-e-balgham” (applying the above functions on abnormal phlegm, called “Balgham” in ITM, is used to evacuate morbid matters produ...
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SYNTHESIS, CHARACTERIZATION AND PERSISTENT DNA BINDING, ANTI-MICROBIAL AND CYTOTOXICITY STUDIES OF NOVEL COPPER (II) COMPLEXES CONTAINING L-TRYPTOPHAN AND HETEROCYCLIC BASE
The copper (II) complexes, [Cu(phen)(tryp)I] (1), [Cu(phen)(tryp)Cl], (2) [Cu(phen)(tryp)SCN] (where phen = 1,10-phenanthroline and tryp = tryptophan ) has been synthesized and characterized by Infra-red Spectra, UV–Visible Spectra, EPR Spectra and elemental analysis methods. Binding interactions mode of the complexes with calf thymus DNA (CT-DNA) were investigated by UV–Vis absorp-tion titrat...
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EVALUATION OF PROTECTIVE EFFECT OF AQUATIC WEED HYDRILLA VERTICILLATA AGAINST LEAD INDUCED ACUTE LIVER TOXICITY IN FISH
The present study is designed to investigate the hepatoprotective effect of Hydrilla verticillata on lead-induced hepatic damage in freshwater fish. The fish were treated with a sub-lethal concentration of lead acetate to induce liver damage and fed with supplementary feed containing 20% of hydrilla dry powder. After 21 days of treatment, the liver was removed, and hepatotoxicity and its preventio...
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NANONEEDLE MEDIATED NONINVASIVE AND PAINLESS TRANSDERMAL DELIVERY OF INSULIN
We have explored the nanoneedles from nanofabrication techniques, which could penetrate both nuclear and cellular membranes of cells. We received the individual nanoneedles with a tip diameter of 220-250 nm and the desired microscale length ~1 to 100 μm, which enable them for transdermal delivery of selective drug molecule by piercing stratum corneum, the outermost layer of skin. These nanoneedle...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL METHYLPYRIMIDINE DERIVATIVES AS AN ANTIDIABETIC AND ANTIHYPERLIPIDEMIC AGENTS
Diabetes and hyperlipidemia become a major risk factor for cardiovascular diseases in the world. Hyperlipidemia is a relatively common problem in patients with poorly controlled diabetes. In searching for a new class of antidiabetic and antihyperlipidemic agents, many compounds with pyridine moiety have been found to possess good activity against diabetes and hyperlipidemia. The present study was ...
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RELATED SUBSTANCES BY HPLC METHOD FOR THE DETECTION AND EVALUATION OF IMPURITIES IN EZETIMIBE DRUG MATERIAL
The gradient HPLC method was developed to detect and quantify four related substances (FIP, FHO-2, STG-01, and desfluoro) in ezetimibe drug material. The efficient separation was carried out on Water X-Select CSH C18 column (4.6 mm × 100 mm, 2.5 μm). The impurities were separated in gradient mode of elution with 0.1% trifluoroacetic acid in water (mobile phase A) and 0.1% trifluoroacetic acid in...
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DEVELOPMENT AND VALIDATION OF NITECAPONE IN HUMAN PLASMA USING TOLCAPONE AS INTERNAL STANDARD BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
The present LC-MS/MS method for estimation of Nitecapone in human plasma using Tolcapone as an internal standard is established and validated as per FDA guidelines. A good response was obtained with ZORBAX Eclipse plus C18 column (150 mm × 4.6 mm ID, 5 μm) and mobile phase with a mixture of 0.01 M Ammonium phosphate buffer with pH adjusted to 5.0 with OPA and Acetonitrile (70:30, v/v) at a flow ...
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DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD OF APIXABAN IN COMMERCIAL DOSAGE FORM
The aim of this study is to develop a sensitive, specific, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method and validate it for the quantification of process-related and degradation impurities of apixaban; an anticoagulant drug. The chromatographic separation was achieved on a Sigma-Aldrich’s Ascentis Express® C18 (4.6 mm × 100 mm, 2.7 µ) HPLC column wi...
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A SENSITIVE LC-MS/MS ASSAY FOR THE DETERMINATION OF NAFTOPIDIL IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
A specific, rapid, and sensitive LC-MS/MS assay was developed and validated for the determination of Naftopidil in human plasma. Naftopidil d7 was used as an internal standard (IS). A faster and one-step protein precipitation (PP) technique was employed for sample preparation. The processed samples were chromatographed on a C18 column using ammonium formate (5mM) buffer in combination with acetoni...
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FORMULATION AND OPTIMIZATION OF CHLORTHALIDONE LOADED NANO-PARTICLES BY ANTISOLVENT PRECIPITATION USING BOX-BEHNKEN DESIGN
Chlorthalidone is a long-acting diuretic recommended for treatment of oedema associated with congestive heart failure. It is oral active diuretic mainly acting on distal convoluted tubule of nephron. Chlorthalidone is poorly soluble in water at room temperature. Nanoparticles have great potential as a carrier and can improve the solubility of poorly water-soluble drugs like chlorthalidone. The aim...
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