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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Most Cited

CITATIONS REPORT: (Source- Google Scholar)
 
Year 202020212022Total
No. of Published Articles 745760548 2053
Citations 69926321 983
Projected Impact Factor 3.7620.64  
Total Citations: 48275
 
Title
Views
PDF
Cited
3.

G-QUADRUPLEX MOTIFS IN C MYC PROMOTER REGION AND THE ROLE OF VARIOUS SMALL MOLECULE LIGANDS/PROTEINS IN STABILIZING THIS PROMOTER REGION

One of the essential scientific research concluded that DNA / RNA forms the hereditary or the genomic material in all life forms. The double-helical model given by Watson and Crick further added to the biological findings, and since then, various other DNA structures have been established viz., triple-stranded structures, quadruplexes, higher-order structures such as G-wires, polyads, etc. This re...

S. Tyagi *, S. Saxena, N. Kundu, T. Sharma and S. Kaur

Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).22-43

22-43

1922

1159

4.

BIOTHERAPEUTICS AS DRUGS, ITS DELIVERY ROUTES AND IMPORTANCE OF NOVEL CARRIERS IN BIOTHERAPEUTICS

Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has...

H. Chinthaginjala, K. Kalpana *, S. P. Manchikanti, P. G. Reddy, S. Karamthoy and N. R. Vennapusa

Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).44-56

44-56

2068

1252

5.

SMARTPHONE IS IT “BEHAVIOUR ADDICTION OR SUBSTANCE ABUSE DISORDER”: A REVIEW TO FIND CHEMISTRY BEHIND

Several behavioral addictions have been hypothesized as having similarities to substance abuse addictions. The DSM-4-TR has designated formal diagnostic criteria for several addictive disorders classifying them as impulse control disorders, a separate category from substance use disorder.  There have been a lot of behavioral addiction studies like tanning, cosmetic surgery, sexual addiction, etc....

B. Sharma, P. Kumar and P. Sharma *

Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).57-64

57-64

2981

1479

7.

ROLE OF POLYMERS IN SUSTAINED RELEASED MICROBEADS FORMULATION: A REVIEW

The aim of this article is to provide a wide-angle prospect of the detailed information of pharmaceutical polymers in sustained released micro-beads dosage forms. Polymers have played an integral role in the advanced drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and constant release of both hydrophilic and hydroph...

M. Bhupathyraaj *, S. Pole and R. Vijayarani

College of Pharmacy, National University of Science and Technology, Muscat, Oman.

DOI: 10.13040/IJPSR.0975-8232.12(1).76-84

76-84

2010

923

8.

GENETIC BACKGROUND ASSOCIATED WITH THE PROGRESSION OF NON- ALCOHOLIC FATTY LIVER DISEASE TO LIVER FIBROSIS

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAF...

M. Nooreen *, S. Fatima, M. Sultana, Z. Fatima and Z. Unnissa

Department of Pharmacy Practice, Mesco College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).85-94

85-94

1089

658

9.

FORMULATION OF MICRO BEADS: A REVIEW

The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration. This could be achieved through multiparticulate dosage form like beads which are divided into many individual units, so, called subunits, each exhibiting some desired characteristics. Micro particulate drug delivery systems ...

M. Bhupathyraaj *, A. Ahuja, Jayasekher and S. Pole

College of Pharmacy, National University of Science and Technology, Muscat, Oman.

DOI: 10.13040/IJPSR.0975-8232.12(1).95-103

95-103

4207

2295

10.

CANDIDATURE OF THE SYNTHETIC CASPASE INHIBITORS AS NEW ANTI-SARS-COV-2 DRUG DISCOVERY, IN-SILICO MOLECULAR DOCKING

The new pandemic virus identified as severe acute respiratory syndrome Coronavirus 2 is the etiological agent responsible for the pneumonia outbreak that ended with respiratory failure. The main protease (MPRO) is a key enzyme for SARS-CoV-2, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we determine the mech...

A. M. M. Zaki *, Y. M. Ahmed and E. M. N. Abdelhafez

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(1).104-19

104-119

2678

2294

11.

DESIGN, DEVELOPMENT AND SYNTHESIS OF NOVEL CHIRAL DERIVED MOLECULES, POTENTIALLY ACT AS RNA POLYMERASE NSP-12 AND NSP-6/10 COMPLEX INHIBITORS AGAINST COVID-19

Novel Di and Tridentate chiral molecules and its analogues were designed and synthesized in that the chiral amino ester and 2-amino-3, 5-dibromobenzaldhehyde were condensed. Further, it has coupled with Cassic acid to form desired active molecules. The developed compounds are evaluated for molecular docking to check potency and may represent potential drug candidate inhibitors of RNA dependent RNA...

M. Balaachari *, M. Menaga and S. P. Sri

Bioneemtec India Private Ltd, Women’s Biotech Park, Siruseri, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).120-28

120-128

1767

1220

12.

IN-SILICO BINDING AFFINITIES OF ALKALOID COMPOUNDS ON NICOTINIC ACETYLCHOLINE RECEPTOR α3β4 FOR SMOKING CESSATION TREATMENT

Nicotinic acetylcholine receptor α3β4 is considered as a potential target for anti-smoking drug discovery. In this study, in-silico approaches, including molecular docking and molecular dynamics simulation were applied to investigate binding affinities of 300 alkaloids into the α3β4 (Pdb id: 6PV8). The docking results showed that most of the alkaloids fitted well into the binding pocket of α3...

G. L. T. Nguyen, T. T. B. Tran and P. T. V. Nguyen *

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

DOI: 10.13040/IJPSR.0975-8232.12(1).129-35

129-135

2839

1090

13.

PROTECTIVE ROLE OF MELATONIN AND TAURINE AGAINST TOXICITY INDUCED BY CAFFEINE IN BRAIN BY ABROGATION OF OXIDATIVE STRESS, DECREASE APOPTOSIS, AND ALTERS CEREBRAL MONOAMINE NEUROTRANSMITTERS IN MALE ALBINO RATS

The current study aimed to investigate the protective effects of taurine and melatonin against caffeine-induced brain damage in rats. 36 male albino rats were divided into 6 groups: Group I: control, group II: Rats received 20 mg/kg melatonin for 28 days. Group III: Rats received 50 mg/kg taurine dissolved in distilled water daily for 28 days. Group IV: Rats received 50 mg/kg caffeine dissolved in...

R. A. Sayed, S. M. Khadrawy, H. M. Mohamed and M. S. Aly *

Genetics Branch, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(1).136-48

136-148

2262

1161