Posted by admin on Dec 25, 2014 in |
Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of Prednisolone Sodium Phosphate in Pharmaceutical tablet dosage form. PSP exhibiting λ max at 246nm in solvent media 100% water and obeyed linearity in the concentration range of 2 to 12µg and exhibited good correlation coefficient (R2=0.999). This method was successfully applied to the determination of PSP content in four different marketed brands from local market and the results were in good agreement with the label claims. The percentage recovery was found to be 99.80±0.238. The sample solution was stable up to 10 hours.The method was validated statistically and studies for linearity, precision, repeatability, and reproducibility. Various methods for analysis of the Prednisolone Sodium Phosphate are available but are time consuming and expensive. But...
Read More
Posted by admin on Dec 25, 2014 in |
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance data reveals that all metal chelates of schiff bases are non electrolytes. IR spectra show that ligand is coordinated to the metal ion in a bidentate manner. From the magnetic and electronic spectral data it is found that the geometrical structures of these complexes are square planar. The activity data show the metal complexes to be more potent antifungal and antibacterial than the parent schiff base ligands against one or more fungal and bacterial...
Read More
Posted by admin on Dec 25, 2014 in |
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and night blindness, skin and stomach disorders, ulcer, common fever, rheumatism, bronchitis, cancer etc., Leaves are the most widely used plant part. During the present study it has been observed that the ethnobotanical systems and herbal medicines as therapeutic agents are of a paramount importance in addressing health problems of traditional communities. The indigenous knowledge available with these people plays an important role in quick and proper identification of natural...
Read More
Posted by admin on Dec 25, 2014 in |
The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD50 value. Our studies was extended to include the effect of the tested doses on different biochemical parameters including serum glucose concentration, transaminases and phasphatse activities, total protein, albumin, urea, uric acid, and creatinine levels in serum. In diabetic mice, serum glucose concentration, transaminases and phasphatse activities, urea, uric acid and creatinine levels were significantly increased but level of serum total protein and albumin were decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of E. alba leaves (200 mg/kg b. wt.), on comparison with diabetic group showed a significant decrease in transaminases and phasphatse...
Read More
Posted by admin on Dec 25, 2014 in |
The objective of study to evaluate a drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for comparing the test drug diazepam 4mg/ kg applied transcranially, whereas both water for injection intraperitoneally and seasme oil transcranially used as a control group. In rod walking test and locomotor activity test used mice for evaluating transfer latency and mean locomotion for 05 minutes and it was observed that Diazepam transcranially has a significant amnesic effect (p<0.0001) as compared to control, and as same like standard. In elevated plus maze, morris water maze, and the pole climbing test have been used rats for evaluating transfer latency, escape latency and avoidance latency; it was observed that Diazepam transcranial has a significant amnesic effect (p<0.0001) as compared to control, and...
Read More
