Posted by admin on Jan 31, 2026 in |
Background: Psychiatric disorders requiring chronic use of psychotropic drugs can cause a wide range of potential adverse effects that can have life-threatening outcomes if not detected and treated on time. This study is aimed towards monitoring and assessing Adverse Drug Events caused by psychotropic drugs. Methods: A prospective observational study was done among 100 patients in Psychiatry Indoor Patients Department from January 2019 to August 2020 using convenient consecutive consenting samples to perform the tests. Results: The study included 100 psychiatric patients, majority suffering from schizophrenia, followed by bipolar mood disorder, major depressive disorder and obsessive-compulsive disorder. Among antipsychotics, maximum side effects were seen in patients who were on haloperidol and least in patients on olanzapine. Extrapyramidal reactions were most common with haloperidol. Clozapine caused the most sedation and hypersalivation. Among SSRIs, escitalopram had the highest side effects, including the most sexual side effects among all antidepressants. Valproate caused the most side effects, including confusion and more weight gain, tremor, and nausea than lithium. Conclusion: Haloperidol and risperidone caused...
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Posted by admin on Jan 31, 2026 in |
Aims: The study was conducted to evaluate the diuretic effect of ethanol extract of Vitex trifolia leaves in albino rats. Methods: Normal rats were divided into 4 groups of 6 animal each. Group I (Control) treated with 2% Gum Acacia in distilled water orally, Group II (Standard/F20) treated with Furosemide 20mg/kg b.w. orally. Group III and IV treated with Ethanol extract of Vitex trifolia L. leaves at a dose of 300mg/kg b.w. and 600mg/Kg b.w. respectively. Urine collected 5 hrs after the administration of drug. Then the total urine volume was measured. Electrolyte excretion (Na+, K+, Cl-) was estimated for assessment of the various diuretic activity by Sensocare ST 200 plus electrolyte analyzer in Biochemistry Department, JNIMS. Result: A Significant increase in urine output was seen with ethanol extract of Vitex trifolia treated group of animal when compared to normal control. Diuretic activity also increases in a dose dependent manner. Significant increase in sodium, potassium and chloride was also seen in the group treated with the plant extract at...
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Posted by admin on Jan 31, 2026 in |
Background: Adverse drug reactions (ADRs) are a significant challenge in clinical medicine frequently contributing in increasing morbidity, hospital stays, and treatment costs. Despite advancements, irrational prescribing remains common and compromises patient safety. Methods: This prospective, cross-sectional observational study was conducted over 13 months (Feb 2024–Mar 2025) at Maharani Laxmi Bai Medical College, Jhansi. A total of 200 patients with suspected ADRs were enrolled. ADRs were assessed using the Modified Hart wig and Siegel severity scale and WHO-UMC causality scale. Post-ADR prescriptions were analyzed for WHO prescribing indicators and cost-effectiveness. Results: The mean patient age was 38.4±12.6 years, with males comprising 55.5%. Dermatological ADRs were predominant (46%), followed by systemic symptoms (20.5%), gastrointestinal (15%), hepatic (7%), and others (11.5%). Antibiotics (52.5%) and NSAIDs (18%) were the main offending drug classes. Most ADRs were of moderate severity (94%) and classified as “possible” (55.5%). Post-ADR, the average number of drugs per prescription was 2.37, 66.95% of which were from the National List of Essential Medicines (NLEM). The average daily prescription cost was...
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Posted by admin on Jan 31, 2026 in |
Background: Teenage pregnancy is a significant public health concern, particularly in developing countries, and is often linked to higher risks of adverse obstetric and neonatal outcomes. This study aimed to assess the association between teenage pregnancy and fetomaternal morbidity and mortality, compared with adult primigravida pregnancies. Materials and Methods: A cross-sectional observational study was conducted from March 2021 to February 2022 in the Department of Obstetrics & Gynaecology, R.G. Kar Medical College and Hospital, Kolkata. A total of 300 primigravida women fulfilling inclusion criteria were enrolled and divided into two groups: Group A – teenage mothers (10–19 years, n=150) and Group B – adult mothers (20–35 years, n=150). Socio-demographic variables, antepartum complications, delivery details, postpartum complications, and neonatal outcomes were recorded and analysed using appropriate statistical tests. Results: Teenage mothers showed significantly higher rates of anaemia (72% vs 56.6%, p=0.005), hypertensive disorders of pregnancy (28.7% vs 18.7%, p=0.041), preterm deliveries (32% vs 18.7%, p=0.028), and genital tract injuries (16.7% vs 8.7%, p=0.037) compared with adults. Neonatal complications were also...
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Posted by admin on Jan 31, 2026 in |
Silver nanoparticles (AgNPs) are metallic nanoparticles that play an important role in nanomedicine as antimicrobial agents, wound management, anti-diabetic, burn care, cancer diagnosis and therapy, etc. Natural polyphenol curcumin, which is derived from turmeric, is well-known for its ability to heal wounds and has been shown to have antibacterial, antioxidant, and anti-inflammatory properties. Although curcumin is used more widely, its hydrophobic nature restricts its effectiveness. To increase its activity, curcumin can be combined with AgNPs with the help of a precursor. In the current work, curcumin-AgNP (CUR-AgNP) was made chemically with sodium citrate acting as a reducing agent and silver nitrate serving as a precursor. The prepared AgNP was characterized for particle size, PDI, zeta potential, Fourier-transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), X-ray diffraction (XRD). Carbopol was used to convert the CUR-AgNP into a gel, which was then characterized in terms of pH, gel strength, viscosity, and spreadability. The capacity of the targeted gel formulation to heal wounds in-vivo was examined in Albino Wistar rats. The results...
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