Posted by admin on Dec 25, 2014 in |
Morinda Pubescens belonging to the family rubiaceae has been reported to posses many medicinal properties according to indigenous system of medicine. The search for biologically active compounds from natural sources has always been of great interest to researchers looking for new drugs useful in infectious disease. In the present study, the various extracts of Morinda Pubescens bark was tested for their antibacterial and antifungal activities against gram positive bacteria such as Staphylococcus aureus, Bacillus cereus, gram negative organisms such as Escherichia coli, Pseudomonas aeruginosa and fungi such as Candida albicans, Aspergillus niger respectively by cup plate method. All the extracts were effective against the tested microorganism which was comparable with standard antibiotics. The ethanolic extract showed highest zone of inhibition then other extracts tested. The zone of inhibition of the extracts of Morinda Pubescens indicating that the plant of Morinda Pubescens can fight these microorganism effectively due to the presence of phenol,triterpinoids and tannins it could be better alternative to the modern...
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Posted by admin on Dec 25, 2014 in |
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, and sustaining release of Glipizide for formulating uniform, spherical Glipizide pellets. Speed and time of spheronization is critical parameter for optimum sphericity. The Optimum speed and time of operating spheronization is 1350 rpm and 15 min. The results of this study showed that combination of HPMC K100M LVCR as hydrophilic matrix polymer and PEG 400 as potential plasticizer is effective and useful for sustaining the Glipizide release to treat diabetes mellitus. The in-vitro studies showed Q16 at approximately 80% cumulative release in case of F4, F5, F6, It indicates that this system can sustain the release upto 24 h which is desirable for sustained release specificity. Although, the hydrophilic matrix polymer optimization is critical for drug...
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Posted by admin on Dec 25, 2014 in |
Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of Prednisolone Sodium Phosphate in Pharmaceutical tablet dosage form. PSP exhibiting λ max at 246nm in solvent media 100% water and obeyed linearity in the concentration range of 2 to 12µg and exhibited good correlation coefficient (R2=0.999). This method was successfully applied to the determination of PSP content in four different marketed brands from local market and the results were in good agreement with the label claims. The percentage recovery was found to be 99.80±0.238. The sample solution was stable up to 10 hours.The method was validated statistically and studies for linearity, precision, repeatability, and reproducibility. Various methods for analysis of the Prednisolone Sodium Phosphate are available but are time consuming and expensive. But...
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Posted by admin on Dec 25, 2014 in |
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance data reveals that all metal chelates of schiff bases are non electrolytes. IR spectra show that ligand is coordinated to the metal ion in a bidentate manner. From the magnetic and electronic spectral data it is found that the geometrical structures of these complexes are square planar. The activity data show the metal complexes to be more potent antifungal and antibacterial than the parent schiff base ligands against one or more fungal and bacterial...
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Posted by admin on Dec 25, 2014 in |
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and night blindness, skin and stomach disorders, ulcer, common fever, rheumatism, bronchitis, cancer etc., Leaves are the most widely used plant part. During the present study it has been observed that the ethnobotanical systems and herbal medicines as therapeutic agents are of a paramount importance in addressing health problems of traditional communities. The indigenous knowledge available with these people plays an important role in quick and proper identification of natural...
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