Posted by admin on Aug 1, 2014 in |
The effectiveness of drugs is directly related to the quality thus quality evaluations of medications throughout the production process and distribution are very essential. Counterfeit medications are known to have poor quality as the medications are in the market without the consent of the regulatory body. A total of 11 samples of paracetamol tablets were collected from kiosks, one from each sub city of Addis Ababa, Ethiopia except Addis Ketema where Merkato (the biggest open market in Africa) is located in which two sampling sites were selected. The tablets were assessed for different quality parameters; weight variation, friability, diameter, thickness, assay, disintegration and dissolution using compendial methods. The weight variation, friability, diameter and thickness results were in accordance with the British Pharmacopeia for all samples. The samples also comply with the BP disintegration requirements except a sample from Bole sub city, Paracetamol EPHARM (2110743). The dissolution profiles of the two brands (Asmol and Kelvin) and a generic Paracetamol, EPHARM were evaluated and the results show that all the samples...
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Posted by admin on Aug 1, 2014 in |
The study was aimed to compare the effect of lipid lowering only through Atorvastatin and lipid lowering combined with HDL-C raise by adding Niacin on the lipid profile and renal outcomes in renovascular disease. It was prospective, analytical hospital based study. In diagnosed patients Atorvastatin (20mg) and/or in combination with Niacin Extended Release 500mg/day was prescribed randomly distributed in two groups of equal size (n=60) for four months. 50 healthy individuals were also added to get local reference values. Pre and post treatment lipid profile and Apo A-1 were measured and analyzed using t-test at alpha 0.05. There was no difference in the baseline values. Atorvastatin induced a significant reduction in total cholesterol (p<0.05) and LDL (p<0.05), while decrease in TG and vLDL levels remained insignificant. It also causes an increase in HDL (p<0.05) and Apo A1 that was non-significant. Atorvastatin combined with NER reduced cholesterol (p<0.05), TG (p<0.05), LDL (p<0.05) enhanced HDL (p<0.0001) and Apo A1 (p<0.01). The inter-group comparison of both treatments demonstrated relatively better outcomes following...
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Posted by admin on Aug 1, 2014 in |
The aim of the present study was to determine the antibacterial activity of crude extracts from root parts of Catharanthus roseus against several bacterial species of clinical significance. Root part of C. roseus was extracted in appropriate solvent followed by evaluation of antibacterial activity by agar well diffusion assay against a total of eight bacterial stains. Further, minimum inhibitory concentration(s) was evaluated for the crude extracts. Among all the extracts, the chloroform extract was found to be most active against almost all the bacterial species tested. Gram-positive bacteria were found more sensitive than Gram-negative bacteria. Other focuses included the determination of antioxidant activity using DPPH assay and IC50 (Inhibitory concentration) values were also determined using broth dilution assay. Preliminary phytochemical screening of the crude chloroform extract revealed the presence of alkaloids, flavonoids, tannins, saponins, proteins and phenolics. The study promises an interesting future for designing potentially active antibacterial agents from Catharanthus...
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Posted by admin on Aug 1, 2014 in |
Achyranthes aspera (Amaranthaceae) is an important medicinal herb found as a weed throughout India. It has been used in almost all the traditional system of medicine, ayurveda, unani, and sidha from the ancient time. It serves as a folk medicine in traditional uses. In present study, the methanolic extract and aqueous extracts of leaf, stem, inflorescence and roots of Achyranthes aspera was screened. The Physio-Chemical Parameters of Achyranthes aspera like determination of moisture content, total ash content, acid insoluble ash content, water soluble ash content and solvent extractive values were done. Qualitative phytochemicals revealed the presence of alkaloids, saponins, flavonoids and glycosides in each extract. In A.aspera extract the moisture content, total ash content, insoluble ash content in stem and roots was more than leaf and inflorescence and water soluble ash content was found highest in inflorescence followed by stem then leaf and least in...
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Posted by admin on Aug 1, 2014 in |
A new, precise, rapid, accurate RP-HPLC method was developed for the estimation of Decitabinein pharmaceutical dosage form. After optimization the good chromatographic separation was achieved by Isocratic mode with a mixture of Ammonium Acetate buffer of pH 4.5: Acetonitrile (985:15) v/v as the mobile phase withDevelosil Rp Aqueous-AR-5 (150 x 4.6 mm, 5 µm), column as stationary phase at flow rate of 1.5 mL/min and detection wavelength of 244 nm. The Retention time of decitabine was found to be 3.796 min. The linearity of this method was found in the concentration range of 50-150 µg/mL. The correlation coefficient R2value is found to be0.998. The LOD for this method was found to be 0.0003 µg/mL. The LOQ for this method was found to be 0.0009 µg/mL. This method was found to be good percentage recovery about 99.77 indicates that the proposed method is highly accurate. The specificity of the method shows good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the...
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