Posted by admin on Jul 1, 2014 in |
Objective: The present study was aimed to evaluate the antidiabetic activity of 1-(4-(Dimethylamino) benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone i.e. a novel Isatin derivative diabetic rats. Methods: The antidiabetic activity of Isatin derivative was evaluated against alloxaninduced diabetes in rats. Diabetes in rats was induced by administration of alloxan monohydrate (120mg/kg, b.w, p.o) as a single dose. The diabetic rats were treated with single dose of test compound at a dose of 50 and 100mg/kg. Blood samples were collected at different intervals and analyzed for fasting glucose levels, total cholesterol (TC), triglycerides (TG) and High density cholesterol (HDL-C) levels using respective kits. Results: Treatment with test compound with a single dose of 50 and 100mg/kg to diabetic rats showed a significant dose dependant (p<0.01) reduction of fasting blood glucose levels along with mild change of lipid profiles (TC, TG, HDL-C) indicating the antidiabetic activity of test compound. Conclusion: The study results confirmed the antidiabetic activity of 1-(4-(Dimethylamino)benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone in...
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Posted by admin on Jul 1, 2014 in |
In this study, the fatty acid content, antioxidant activities and antimicrobial potential of oil obtained from the root of Hippocratea africana was investigated. Results showed that the oil was characterized by oleic acid (65.73%), palmitic acid (20.34%) and linoleic acid (6.90%) as the most abundant fatty acids with a oleic acid/linoleic acid ratio of 9.52. The oil possessed potent antioxidant activity (IC50 = 75.00µg/ml) and exhibited significant metal chelating potentials (EC50= 7.4mg/ml). It also showed notable antimicrobial activity against the tested human pathogens. MIC values indicated bactericidal activity against S. aureus (MIC =0.05mg/ml), S. pyogenes (MIC =0.17mg/ml) and fungicidal activity against C. albican (MIC =0.06mg/ml). These results support to some extent, the medicinal potential of Hippocratea africana...
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Posted by admin on Jul 1, 2014 in |
The method of entrapment of the drug in the microcapsules structure prepared with different theoretical drug content (TDC) and having different particle size ranges were studied using x-ray diffraction and DSC analysis methods. Also, in the light of the analysis methods, a trial to correlate the actual microcapsule structure with the actual drug content (ADC) and the division mechanism suggested by the author was also studied. The results showed that the drug entrapped in more than one form in the microcapsule structure. At the first, the drug entrapped in the microcapsules structure as a solid solution form which is concluded as the result of disappearance of all characteristic peaks of the drug in both x-ray diffraction pattern and DSC. The amount of drug in solid solution form depends on the physico-chemical characters of the drug and the polymer. After that increasing TDC leads to increasing the amount of the drug crystal in the microcapsule structure. Between those two forms another minute form may be formed as a result of...
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Posted by admin on Jul 1, 2014 in |
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, series of five novel azetidinones are synthesised which involves the hydrazinolysis of 4- nitro ethyl benzoate with 99% hydrazine hydrate in ethanol in microwave oven to yield the hydrazides.Then hydrazides are condensed with different substituted aromaticaldehydes in DMSO in microwave to form respective Schiff base. Then formation of Schiff bases is followed by cyclisation with chloro acetyl chloride and triethyl amine in DMF to yield corresponding azetidinones. Structures of synthesised compounds were confirmed by 1H NMR, Mass spectral analysis. The compounds are evaluated for their antimicrobial activities. The activities are due to cyclic carbonyl group in azetidinones. Some of the compounds have shown comparable antimicrobial activities against all the microbial...
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Posted by admin on Jul 1, 2014 in |
The antibacterial activities of water extracts of the three major parts of the date palm fruit were compared against Eschereshia coli; Klebsiella pneumonia; Salmonella enteritidis; Pseudomonas aeruginosa; Staphylococcus aureus using the agar well diffusion method. Endocarp extract showed a wide range of activity against all Gram negative bacteria while it exhibited a low activity against Gram positive bacteria.The date tissue and endocarp didn’t show any activity against Klebsiella pneumoniae with a low or no activity against Pseudomonas aeruguinosa. Date tissue extract alone didn’t exhibit any activity against Klebsiella pneumoniae and Pseudomonas aeruguinosa. All types of extract were active against Escherichia coli. A consistently lower susceptibility of Klebsiella pneumonia and P. aeruginosa indicated its capability for developing resistance against various antibacterial substances. Antibacterial activities displayed by all extracts especially the endocarp also signified their remarkable potential for exploration of effective natural antibacterial agents against common pathogenic...
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