Posted by admin on Aug 1, 2014 in |
Aim of present investigation was to develop self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles. All formulations of ibuprofen SEDDS showed globule size in micrometer range, good stability with no phase separation, creaming or cracking and rapidly formed emulsion which was clear. All formulations showed more than 90% of drug release within 30 min. The SEDDS showed improved dissolution rate compared to marketed product. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SEDDS showed more significant activity than the marketed...
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Posted by admin on Aug 1, 2014 in |
The Gulf of Mannar, is a unique marine habitat with diverse of macroalgae. Macroalgae are primitive non flowering marine plants, which have rich sources of bioactive compounds (i.e., proteins, peptides, amino acid, polysaccharide, alkaloids etc). The selected red algaeGelidiela acerosa and Acanthophora spicifera collected from the Gulf of Mannar, southeast coast of India. In the present study, the anticancer potential of the methanol (crude) extract from G. acerosa and A. spicifera was tested for probable anticancer activity in Dalton’s Ascitic Lymphoma (DAL) cells. The cells were tested in Swiss albino mice. The results show that G. acerosa and A. spicifera algae extract were the most effective against DAL cells in mice respectively had significant anticancer activity and it might be a good candidate for further investigation in order to develop a natural compound as an anticancer agents, which can be utilized for the production of potential anticancer drug and novel pharmaceutical...
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Posted by admin on Aug 1, 2014 in |
The aerial parts of Scoparia dulcis Linn. belonging to family Scrophulariaceae. Traditionally are used as antiulcer, antibacterial, antifungal, cytotoxic, antimicrobial, antianaemic, analgesic, antidiabetic, hyperlipidaemia, hepatoprotective etc. From literature survey the aerial parts of Scoparia dulcis Linn. are rich source of flavonoids, tannins, phenolic compounds but not yet scientifically investigated for nephroprotective activity. So in order to give scientific background the aerial parts of Scoparia dulcis Linn. was evaluated for nephroprotective activity by gentamicin induced nephrotoxicity. The present study carried out with Pharmacognostic examination like macroscopic, microscopic, proximate values and preliminary phytochemical test evaluation of alcohol and water extract; And their Pharmacological evaluation that gentamicin at dose of 100 mg./kg. BW/day I.P. rout produces significant nephrotoxicity as evidenced by decreased in body weight, urine volume & elevate in kidney weight, serum urea, uric acid, serum creatinine, with renal tubular necrosis. After treatment the alcohol and water extracts each (200 mg./kg. B.W./ day I.P.) of aerial parts of Scoparia dulcis Linn. Show significant decreases (p˂0.001) serum urea, uric acid, creatinine level,...
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Posted by admin on Aug 1, 2014 in |
In the present work, efforts have been made to model the antibacterial activity of 4-thiazolidone derivatives against pathogenic bacteria P. aeruginosa by using QSAR (quantitative structure-activity relationship) methodology. Multivariate analysis gave excellent model which was tested using cross validation using leave one out method. The cross- validation method was applied to the data set in order to prove the predictive power of statistically significant QSAR models, which help to explore some expectedly potent compounds. The best model predicting the antibacterial activity indicated that the 2D auto-correlation, 3D and WHIM parameters such as MATS8p, RDF070u, RDF035e, Mor30v (3D) and E1u (WHIM Parameter) are very effective in describing the antibacterial activities of these compounds. The study revealed that E1u, MATS8p, RDF035e and RDF070u contribute positively whereas contribution of Mor30v contributes negatively to the antibacterial activity. The compounds with improved antibacterial potential can be successfully designed with selected quantitative structure activity relationship...
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Posted by admin on Aug 1, 2014 in |
Micronutrient deficiencies such as potassium, magnesium and calcium are very common in the general population and it is more predominantly present in the individuals with hypertension and cardiovascular patients. These deficiencies will have a massive impact on present and future cardiovascular health outcomes such as hypertension, myocardial infarction, stroke, etc. Recent efforts to reduce the prevalence of hypertension have focused on non-pharmacologic means, specifically diet in order to overcome micronutrient deficiencies. From most of the studies it is evident that an increased intake of minerals such as potassium, magnesium, and calcium by dietary means to reduce blood pressure in patients with hypertension. This article also focuses on how these minerals influence vaso dilation, rennin- angiotension and aldosterone system, natriuresis, sympathetic nervous system nitric oxide production and vascular injury. On the whole, this review will talk about the roles of potassium, magnesium, and calcium in the prevention and treatment of hypertension with specific emphasis on clinical trial evidence, mechanism of action, and recommendations for dietary intake of these...
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