Posted by admin on Jul 1, 2014 in |
Cordia dichotoma L. family Boraginaceae is a medium sized tree, is taken as food. The immature fruits are pickled and are also used as vegetable. The various extracts and fractions of Cordia dichotoma were screened for their free radical scavenging properties using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and comparing it with butylated hydroxyl toluene (BHT) as standard antioxidant. The methanolic extract of seeds of Cordia dichotoma Linn and its fraction containing Taxifolin showed promising (P<0.001) DPPH free radical scavenging activity at a concentration of 100...
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Posted by admin on Jul 1, 2014 in |
The role of liquid membrane hypothesis has been studied in the mechanism of action of Ertapenem. In the present study transport of selected permeants (glucose, p-amino benzoic acid and ions like magnesium, ammonium, phosphate, calcium, sodium, potassium and chloride) through liquid membrane generated by Ertapenem in series with supporting membrane has been studied. The results indicate that the liquid membrane generated by Ertapenem inhibit the transport of various essential bio-molecules and permeants into the cell. The data indicate that modification in permeability of different permeants in the presence of the liquid membrane is likely to play significant role in the biological actions of Ertapenem. It seems that the formation of liquid membrane by Ertapenem may also contribute for the bactericidal activity of the drug, in addition to its conventionally established mechanism i.e. inhibition of cell wall...
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Posted by admin on Jul 1, 2014 in |
Among numerous species of plants growing in the wild in India, Garike, orDruva or taxonomically the Cynodon dactylon sp. occupies its unique place in the traditions, religions and cultures of different societies. In the present study, Phytochemical screening of methanolic, petroleum ether, ethanolic and aqueous extracts of Cynodon dactylon revealed the presence of 17 different phytoconstituents. Quantitative analysis ofmethanolic extract revealed the concentration of various bioactive constituents.Antimicrobial activity of both Ethanolic and Methanolic extracts of Cynodon dactylon showed good inhibitory effect for all the tested Bacterial and Fungal strains including E. coli, B. subtilis, S. typhimurium, M. luteus, K. pneumoniae, S. aureus, P. vulgaris, P. aeruginosa, C. albicans, A. flavus, A. fumigatus, P. notatum, Sporothrix schenckii, Stachybotrys chartarum and C. neoformans by Agar well method. TLC for all the extracts showed bands in U.V for the presence of Flavonoids, Alkaloids, Phenols and Glycosoids. HPLC analysis of methanolic extract gave peaks at retention time 2.779, 4.115 and 9.840.LC-MS of methanolic extract of Cynodon dactylon showed the presence of eight compounds....
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Posted by admin on Jul 1, 2014 in |
Background: Familial Hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutation in the LDL receptor gene and characterized by raised LDL-C, tendon xanthomata and premature atherosclerosis. Existing therapies for FH such as statins and LDL apheresis do not offer adequate lipid control in most patients, which has led to the search for more definite alternatives. Two new drugs have been approved by the US FDA in the recent past for FH, namely mipomersen, an anti-sense oligo-nucleotide and lomitapide, a microsomal triglyceride transfer protein. Methods: We did a literature search across PubMed to retrieve articles related to efficacy and safety of mipomersen and lomitapide. Results:Mipomersen has been found to have reasonable efficacy in clinical trials over and above that seen with concomitant statin therapy in FH. Lomitapide has also shown evidence of adequate LDL-C reduction in clinical trials though the number of studies performed with lomitapide is relatively fewer. The subcutaneous route of administration for mipomersen may affect compliance especially with long term treatment. The most common adverse reactions...
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Posted by admin on Jul 1, 2014 in |
Simple, accurate and precise spectrophotometric methods for quantitative determination of four drugs viz., Alfuzosin (ALF), Esomeprazole (ESO), Indomethacin (IND), Ketorolac Tromethamine (KET) have been developed based on oxidation of the drugs by alk.KMnO4. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn(VI), absorbed at 610 nm. Initial rate and fixed time method are used for the construction of calibration curves Beer’s law is obeyed in the range 12.5-100µg mL-1 for ALF; 25-150 µg mL-1 for ESO; 2.5-15 µg mL-1 for IND and 6.25-37.5 µg mL-1 for KET. Recovery studies using pure samples and pharmulations in the Beer’s Law limits have been carried out and the methods have been validated in terms of ICH guidelines. Statistical analysis in terms of student’s t- test and variance F- test demonstrate high accuracy and precision and suggest the methods can be applied in bulk drug and pharmaceutical industries.Simple, accurate and precise spectrophotometric methods for quantitative determination of four drugs viz., Alfuzosin (ALF), Esomeprazole (ESO), Indomethacin (IND), Ketorolac...
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