Posted by admin on Mar 1, 2014 in |
In the present study, the alcoholic and aqueous extracts of Thespesia populnea were investigated for their antipyretic activity. Suspension of subcutaneous administration of brewer’s yeast in albino rat leads to pyrexia. Oral administration of extracts at a dose of 500 mg/kg body weight significantly reduced the elevated body temperature of rat. This antipyretic effect has been compared with antipyretic effect of standard paracetamol....
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Posted by admin on Mar 1, 2014 in |
Efficient in-vitro propagation of Tylophora ovata (Lind.) Hook. Ex. Steud was carried out in this present investigation. Nodal segments from the healthy grown plants were used as explants for culturing. Explants were cultured on standard Murashige and Skoog (MS) medium supplemented with different concentration of benzyl amino purine (BAP) and naphthalene acetic acid (NAA) for primary shoot proliferation. Remarkable shoot proliferation was observed in MS medium containing BAP (2.5 mg/L) and NAA (3.5 mg/L). For rooting of the micro shoot, half strength MS medium supplemented with indole acetic acid IAA (2 mg/L) and 3-indole butyric acid IBA (2.5 mg/L) showed the best result. After acclimatization and transplantation, 100% of the in-vitro shoot delivered was found healthy in ex vivo...
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Posted by admin on Mar 1, 2014 in |
ABSTRACT: Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation. Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of CVD. Bilirubin exerts a strong antioxidant effects at physiological plasma concentrations against lipid oxidation in blood artery. Methodology: Parameters were measured on a fully automated analyzer using standard reagent kits in a retrospective study involving 100 male Indian subjects between 35 to 55 years of age. Results: Serum total bilirubin was correlated positively with serum high density lipoprotein (HDL), while it was negatively correlated with glycosylated hemoglobin (HbA1c), there were no statically significance present between serum total cholesterol and serum triglyceride in hospitalized patients, not in healthy subjects. Conclusions: we were concluded that, the serum total bilirubin concentration will be an independent cardiovascular risk factor such as lipid...
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Posted by admin on Mar 1, 2014 in |
Disastrous effects of tobacco consumption on health remain in the focus of preclinical and clinical research. Exposures to tobacco smoke are closely connected to acute and chronic smoke lung dysfunctions and the effects are not restricted to airway inflammation processes. The facts that smoke exposure result in aberrant gene expression and changes in cellular phenotype resulting in clinical patterns. Here we pyrolyzed constituents of tobacco smoke, induced a stress response in human embryonic lung (HEL) cells, which respond with an altered expression of a broad spectrum of genes. We systematically analyzed the genetic expression, using the microarray-technology. After exposure of HEL cells to alkaline or acidic extracts of pyrolyzed smoke, already 2h after exposition the most affected genes (HMOX1, CYP1B1, ID3, and ID2) were rapidly up-regulated, whereas after 24 hours the genes were almost down-regulated. Using DAVID bioinformatics we detected annotation clusters with significant enrichment scores allowing insight into pharmacological processes and molecular functions. In the alkaline and acidic probes in a ratio 24 h versus 2h we identified...
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Posted by admin on Mar 1, 2014 in |
Background: Antimicrobials form an important group of drugs. Increasing prevalence of infections and emergence of resistance to antimicrobials has led to polypharmacy with respect to antimicrobial prescription. Aims and Objectives: To study the prescribing patterns, approval status, adherence to NLEM and WHO-EML and cost of antimicrobials prescribed in surgical departments. Methods: Data was collected from medical records of inpatients that underwent surgical procedures, from SSIMS&RC Teaching Hospital, Davanagere, Karnataka. The antimicrobials were classified based on WHO‐ATC classification and analyzed. Results: Among 464 antimicrobials prescribed to 154 patients, 13.79% were prescribed by generic name, 73.28% were prescribed as parenteral preparations and 16 patients received single antimicrobial agent. Mean duration of hospitalization was 10.56 ± 5.7 days. Beta lactam antimicrobials apart from penicillins (J01D) were the most commonly prescribed. 78.88% of the prescriptions were approved by both DCGI and FDA. 72% of the prescriptions were adhering to the both NLEM and WHO-EML. 72.85% of the prescriptions were single drug formulations. 27.16% were FDCs and 3 of them were not approved either...
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