Posted by admin on Dec 1, 2013 in |
This study evaluated methanolic extract of Filicium decipiens (MFD) on reducing hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. MFD was orally administered once a day after 3 days of streptozotocin -induction at 100,200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, Glucose – 6 – phosphotase , Fructose 1, 6 –phosphotase in hepatic tissues ,TC, free fatty acids , phospholipids, and TG in serum levels were significantly decreased, whereas Hb and HbCA1in blood and serum HDL, Glucokinase, Glucose – 6 – Phosphate Dehydrogenase in hepatic tissues and liver and muscle glycogen level were increased. The dosage of 400 mg/kg is more effective than that of 100, 200 mg/kg. These results suggest that the MFD possesses antidiabetic and hypolipidemic effects in streptozotocin -induced diabetic...
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Posted by admin on Dec 1, 2013 in |
A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the determination of Metronidazole (MTZ) and Ciprofloxacin HCl (CPX) in their bulk drug and marketed formulations. The separation was carried out using a mobile phase of 25mM Potassium dihydrgen phosphate buffer of pH 3.0 consisting of 0.15%v/v Triethylamine, 0.1% Phosphoric acid and Methanol in the ratio of( 60:40v/v). The column used was Zorbax C18 column (250mm x 4.6mm, 5 µm) with flow rate of 1 ml / min using UVD 17 Detector. Detection carried out at 320 nm. The retention times of Metronidazole and Ciprofloxacin Hydrochloride were found to be 3.7 min and 5.6 min, respectively. Developed methods were validated according to ICH guidelines. Linearity was observed at concentration range of 50-250 μg/ml for Metronidazole and 62.5-312.5μg/ml for Ciprofloxacin Hydrochloride followed by Beer’s law. The percentage RSD for the method precision was found to be less than 2%. The proposed method is precise, accurate, selective and rapid for simultaneous determination of Metronidazole and Ciprofloxacin...
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Posted by admin on Dec 1, 2013 in |
Aim: To evaluate safety and efficacy of diclofenac 75 mg/1ml (Dynapar AQ) administered as IV bolus versus diclofenac 75mg/3ml administered as IV infusion in patients with postoperative pain. Methods: 350 postoperative adult patientswere randomized to receive either treatment. Primary efficacy endpoints were time to onset of analgesia and postoperative pain intensity while secondary efficacy endpoints included degree of pain relief and global assessment by patient and investigator. The safety endpoints were pain intensity and grade of thrombophlebitis at injection site. Safety and efficacy endpoints were evaluated over 12 hour study period. Results: Both study drugs were safe and effective throughout study period. However, IV bolus route of Dynapar AQ produced significantly faster onset of analgesia, better improvement in postoperative pain intensity and pain relief upto 1 hour, lesser thrombophlebitis and lesser pain at administration site upto 8 hours. Also, global assessment by patient and investigator was significantly favorable towards Dynapar AQ. Conclusions: IV bolus route of Dynapar AQ is better alternative to IV infusion of diclofenac 75mg/3ml with rapid...
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Posted by admin on Dec 1, 2013 in |
The purpose of this study is to prepare a bilayer gastro retentive tablet of Propranolol HCl using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Propranolol hydrochloride, a nonselective β-adrenergic blocker having short half-life (3-4 hr)and first pass metabolism favors for sustained release dosage form. In this study, a bilayer tablet was prepared which contains an immediate release portion and a floating layer. Gaur gum, Pectin were used as gel forming agents either alone or in combination, Sodium bicarbonate and citric acid as gas generating agent, superdisintegrant sodium starch glycolate for the fast release layer. The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 14 h from the sustaining layer of tablets. The bilayer tablets were characterized by lag time, floating time, weight variation, drug content and dissolution profile. Best Formulation BFT1 [Gaur gum-Pectin (2:1)] shows lag time of 8.0min, floating time of 14 h...
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Posted by admin on Dec 1, 2013 in |
The aim of this study was to prepare buffered tablets of acid labile drug, Pantoprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Its mechanism of action was inhibition of H+/K+-adenosine triphosphate, an enzyme present in the gastric parietal cells. The tablets were prepared by wet granulation method. The formulations contain sodium carbonate, sodium bicarbonate as buffering agents and crospovidone as superdisintegrant. The formulation were prepared, optimized and evaluated by 32 factorial design. In this design independent variables were sodium carbonate, sodium bicarbonate, cross povidone and dependent variables were pH and disintegration time. The tablets were evaluated for friability, hardness, disintegration, dissolution and drug content. The formulation F6 was selected by factorial design it was selected due to results as this formulation maintain neutral pH of stomach and drug release simultaneously within 50 seconds after...
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