Posted by admin on Mar 1, 2013 in |
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this reaction is mild reaction condition and excellent yield with high purity of compounds synthesized. All the synthesized compounds were confirmed by IR, 1HNMR and...
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Posted by admin on Mar 1, 2013 in |
In this study, the antioxidant capacity during UV exposure has been investigated by using a laser-based trace gas detector for the detection of gaseous ethylene as an indicator for lipid peroxidation. Biocream was used as a control and ascorbic acid, butylated hydroxytoluene, phloroglucinol and hydroquinone were added as antioxidants in a mixing concentration of 2.5% (w/w). The experimental results show that there is a decrease in the number of ROS due to the presence of antioxidants, from which ascorbic acid is the most effective. The detection method offers a direct and on-line way to evaluate the capability of antioxidant in reducing the harmful effect of the UV...
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Posted by admin on Mar 1, 2013 in |
Background: Leprosy is one of the infectious diseases of public health importance; it is the leading cause of permanent physical disability as aresult of nerve damage. Individuals with leprosy have emotional stress and anxiety, which may lead to both psychological and psychiatric co-morbidity. Objective: This study was conducted to estimate the prevalence of mental distress among leprosy patients attending ALERT Specialized, Addis Ababa, Ethiopia. Method: Institution based cross-sectional study was conducted from April 2011-June 2011. Alternate patients from the daily register of outpatients were interviewed for symptoms of mental distress using the Self Reporting Questionnaire (SRQ-20). This questionnaire was administered by two trained nurses. Data was analyzed using SPSS version 15. Odds ratio were calculated to see the association of dependent variable with each independent variable. P-value <0.05 were considered as statistically significant. Result: The prevalence of mental distress was found to be 30.9%.Physical disability was also associated with mental distress. This study showed that mental distress was significantly higher in patients with leprosy. Conclusion: This piece of study...
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Posted by admin on Mar 1, 2013 in |
Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of ofloxacin with indion 204 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug: resin and temperature. The resinate was evaluated for taste masking and in vitro drug release. DSC analysis study supported complex formation. ofloxacin- indion 204 complex of ratio 1:1.5 was developed into orodispersible tablet using different superdisintegrants with varying concentration and was evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution and was found superior over conventional formulation. The F5 batch with disintegration time 19.33 Sec ±3.78 and dissolution within 45 minutes 89.642±2.20 was selected as optimized formulation. By an appropriate selection and combination of excipients, it was possible to obtain orodispersible and taste masked...
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Posted by admin on Mar 1, 2013 in |
Rapid, simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Trimetazidine in pure and pharmaceutical formulations. Various methods were developed for estimation of trimetazidine .but a simple extractive photometric method using has not been developed .This method is based on the formation of chloroform soluble ion pair complex of Trimetazidine with bromothymol blue (BTB) in buffer of pH 5.0 with absorption maximum at 409nm. Reaction conditions were optimised to obtain the maximum colour intensity. The absorbance was found to increase linearly with increase in concentration of Trimetazidine. Calibration graph was plotted and the correlation coefficient was found to be 0.998.Beer’s law was obeyed in the concentration range of 1- 7 µg/ml with molar absorptivity of 30*10^3 l /mol /cm .Various analytical parameters have been evaluated and the results have been validated by statistical data. This method has been successfully applied for the assay of drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants.The proposed method is simple, accurate and suitable for quality...
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