Posted by admin on Feb 1, 2013 in |
A study was undertaken to evaluate the efficacy of five various commercial products of ciprofloxacin (a broad spectrum antibiotic), manufactured by different pharmaceutical companies. The drug was evaluated for their performance based on equivalent MIC breakpoint, which is a measure of efficacy of drugs against Staphylococcus aureus ATCC6538 and Pseuomanas aeruginosa ATCC25668 when tested in vitro.The data showed variation for all manufacturers with significant difference (p <0.0001) in efficacy of these drugs at the final dilution level (0.02-0.1µg/µl) against P.aeruginosa. Thus the ciprofloxacin, prepared by various manufacturers are not equally efficacious in inhibiting the growth of S.aureus and P.aeruginosa. Therefore, manufacturers should pay special attention for stringent quality control of drug, and clinicians are suggested to use these antibiotics judiciously in the treatment of patients for these...
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Posted by admin on Feb 1, 2013 in |
Gastro retentive controlled release drug delivery system of Verapamil HCl was formulated to increase the gastric retention time of the dosage form with controlling the drug release pattern. Different grades of hydroxy propyl methyl cellulose derivatives; Methocel K4M and Methocel K15MCR were incorporated for their gel forming properties. Tablet buoyancy was achieved by incorporating a mixture of gas generating agents; sodium bicarbonate and anhydrous citric acid. In vitro dissolution studies were carried out for eight hours using USP XXII paddle type apparatus using 0.1N HCl as the dissolution medium. All the gastro retentive tablets showed good in vitro buoyancy. Tablets swelled radially and axially during buoyancy study. The release kinetics were explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The release rate, extent and mechanisms were found to be governed by polymer type and content. Formulations were characterized by physical characterization, drug loading content and Fourier Transform Infrared spectroscopy (FT-IR). Good results were obtained in the tests and the FT-IR spectroscopic studies indicating no interaction...
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Posted by admin on Feb 1, 2013 in |
The present work aims at evaluating the anti-inflammatory activity of Samadera indica by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The anti-inflammatory activity of the crude ethanol extract, aqueous extract of leaves part of Samadera indica were compared to that of the standard drug diclofenac. The extract in concentration of 250-1000 µg/ml showed a dose dependent inhibition of haemolysis of erythrocyte induced by hypotonic solution. The ethanolic extract of Samadera indica showed significant anti-inflammatory activity in comparison to aqueous extract and with standard drug...
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Posted by admin on Feb 1, 2013 in |
A study was undertaken to evaluate the antioxidant potential of rhizomes of Curcuma amada (Zingiberaceae). Aqueous and ethanolic extracts were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and inhibition of lipid peroxidation activity. Ascorbic acid was used as the standard. In all the models studied, both the extracts showed nearly equal activities thereby justifying the traditional claims ofthe...
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Posted by admin on Feb 1, 2013 in |
Granisetron hydrochloride is most commonly used as an antiemetic agent in treatment associated with cancer chemotherapy induced nausea and vomiting. If the dosage form is designed in sustain release it provide more advantage for the antiemetic therapy. The purpose of this research was to study mucoadhesive buccal patches of Granisetron hydrochloride using the bioadhesive polymers chitosan and sodium alginate. Patches containing chitosan in 1.5%w/v and sodium alginate 2%w/v had maximum percentage of in vitro drug release and ex vivo drug permeation upto 8 hr. The swelling index was proportional to chitosan and sodium alginate content. The surface pH of all patches was found to be satisfactory (7.0 ± 1.5), close to neutral pH; hence, buccal cavity irritation will not be a problem with these patches. The mechanism of drug release was found to be Higuchi (matrix). The formulation F6 was optimized based on good bioadhesive strength (326.96±0.99 N/M2) and sustained in vitro drug release (95.81% ± 3.21% for 8 hr), ex vivo permeation (96.59% ± 3.69% for 8 ...
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