Posted by admin on Nov 30, 2023 in |
Diabetes mellitus has become a global concern with 422 million people affected due to this disease. As the oral hypoglycaemic drugs available in the market have their own set of side effects which can be one of the primary factors towards non-adherence of these medicines among patients, we must explore some natural alternatives in order to deal with this disease in an efficient manner. In such scenario, exploring some intelligent solutions like functional foods can be very helpful as they have the goodness of natural ingredients. The present study focuses on the development of functional food rich in millets, camel milk powder and apple pomace powder. Functional snack bar developed with antioxidant-rich millet mixture (Ragi: Bajra: Kodo: Kutki = 1:1:1:1), insulin-rich camel milk powder and fiber-rich apple pomace powder might have the potential to treat diabetes. Animal studies can be planned in the future in order to validate the product. Moreover, future course of action can comprise of moving into the direction of molecular and cell biology wherein cell...
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Posted by admin on Nov 30, 2023 in |
The present study is aimed to compare the in-vitro antibacterial and antioxidant activities of Aralia cordata Thunberg and Kalopanax septemlobus (Thunb.) Koidzumi (Araliaceae). The antibacterial activity of the two plants was evaluated disc diffusion and minimal inhibition concentration (MIC) method against two Gram-positive bacteria and two Gram-negative bacteria. The tested ether and ethyl acetate fraction of ethanol extract from the two species showed weak antibacterial activity against the tested Gram-positive and Gram-negative bacteria. The ether fraction of the two species exhibited relatively higher antibacterial activity against the tested bacteria as compared to the ethyl acetate fraction. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assay was applied for antioxidant activity. Results showed that the DPPH activity (IC50) of ethanol extracts of the two species ranged from 0.05 ± 0.01 to 0.28 ± 0.07 mg/g and the corresponding values for the ABTS activity (IC50) of ethanol extracts of two species ranged from 0.25 ± 0.01 to 1.80 ± 0.23mg/g. The antioxidant activity of ethanol extracts was higher...
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Posted by admin on Nov 30, 2023 in |
The present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have received attention from researchers globally, leading them to synthesize diverse oxazole derivatives. Oxazole have been reported to possess diverse biological activities like antimicrobial, antiviral, anti-inflammatory and anticancer activity. In this research work some heterocyclic like 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one with potent derivatives for 100 ug/ml are 4-(4-methylbenzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-7), 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl)oxazol-5(4H)-one (PA-13) and are 4-(5-Oxo)-2- (pyrazin-2-yl) 4(5H)-ylidene) methyl) benzonitrile (PA-15) and for 200 ug/ml 4-(4-fluoro benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-4), 4-(4-hydroxy-3-methoxy benzylidene)-2- (pyrazin-2-yl) oxazol-5 (4H)-one (PA-8) and 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-13) shows promising anti-oxidant activities. The method mainly used as hydrogen peroxide radical scavenging activity. Antioxidant scavenging effect of synthesized derivatives also compared with standard Ascorbic...
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Posted by admin on Nov 30, 2023 in |
The current study aims to develop and evaluate herbal mouthwash and ascertain its effectiveness against microbes. Conventionally herbal mouthwashes are used as a disinfectant to lessen the presence of microbes in the oral cavity. Herbal mouthwashes act as a preventative agent for bleeding gums, decoloring teeth, and killing off bad breath germs. The herbal mouthwashes also have inherent benefits of plaque control and inflammation. The formulated mouthwash was prepared using herbs and the extract was extracted by hot water extraction method. Additional analysis of the Phyto ingredients was done where the flavonoid content and phenolic content was estimated as 41.71µg/ml and 76.25µg/ml, respectively and the in-vitro antibacterial assay was performed against Streptococcus mutans and Streptococcus salivarius and the zone of inhibition was calculated as 18mm and 22 mm at the highest concentration. The results indicated that the mouthwash exhibits effective antibacterial qualities. These solutions can be used for various things, including reducing the growth of germs in the oral cavity and for their analgesic, anti-inflammatory, or antifungal...
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Posted by admin on Nov 30, 2023 in |
Introduction: Cervical spondylosis is a degenerative spine disorder commonly affecting the vertebrae and intervertebral discs in the cervical region. Most people commonly present with the complaint of neck pain at least once in their lifetime. It is, therefore, important to ascertain the cause responsible for it. Homoeopathy has a great scope in relieving the pain caused due to spondylosis, thereby preventing the further progress of the disease pathology caused by this disorder. This case was undertaken to assess the efficacy of homoeopathic medicine for managing cervical spondylosis. Case Summary: A 58 years old female complained of neck pain, tingling and numbness with burning over right upper limb for the past 15-20 days. She also complained of headache on and off. No history of vertigo, giddiness was noted. No history of any other major illness was found during the interview. On detailed analysis and repertorization of the case, the homoeopathic medicine Rhus toxicodendron was given. This case was successfully treated with the selected homoeopathic medicine and auxiliary measures, and further...
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