Posted by admin on Sep 30, 2023 in |
Citrus maxima, a well-known citrus species, is an important Assam plant used to treat various disorders by many communities in Northeast India. The local tribes of Northeast India have been using the leaves of C. maxima to eradicate worm infestations since time immemorial. Till date, no scientific research has been conducted on this plant to determine its anthelmintic potential. As a result, an extensive screening was conducted on the anthelmintic potential of ethanol extract of Citrus maxima leaves against Pheretima posthuma using albendazole as the reference standard. Fifty-five Indian adult earthworms were collected and divided into eleven groups of five worms each. This essay considered three concentrations of the standard drug albendazole and the ethanolic extract of C. maxima leaves. This involved keeping track of the time required for the worms’ paralysis and death after being exposed to the drugs. Results showed a dose-dependent increase in the anthelmintic activity with ethanolic extract of Citrus maxima showed the highest activity at the dose of 200 mg/mL. When compared with the...
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Posted by admin on Sep 30, 2023 in |
Polymeric films of pure PVP/ gelatin mixture contain different measures of Barium oxide Nanoparticles to be arranged for projecting. The arranged films’ underlying and associated actual properties are concentrated on utilizing various methods. The acquired information uncovered the present expansion of gelatin and Barium oxide Nanoparticles causes underlying variety in the Poly (vinyl pyrrolidone) organization. The X-ray diffraction (XRD) designs uncover the formless character of the mixture increments along the centralization of Barium oxide Nanoparticles. Composite arrangements exist, affirmed by XRD and FT-IR investigation. The results show that the current expansion of gelatin and Barium Oxides Nanoparticles to Poly (vinyl pyrrolidone) changes the warm way of behaving, such as the mirror progress temperature and warm soundness. Also, the expansion of gelatin and Barium Oxides Nanoparticles produce work on the electrical properties of Poly (vinyl pyrrolidone) film. The visual what’s more, electrical outcomes recommended the appropriateness of these substances in the Optical or potentially electrical...
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Posted by admin on Sep 30, 2023 in |
Background: Post-marketing surveillance via spontaneous Adverse drug reaction (ADR) monitoring and reporting method is in place, even though it is considered as one of the key challenge for under-reporting and establishing the quality of patient safety in the healthcare system. Objective: This study is intended to know the clinician’s opinion (mindset) on the implementation of PvPI-Helpline (Helpline Number) and concise ADR form in In-patient case sheets at a tertiary care teaching hospital, Telangana India as they play a vital role for improving the reporting system of ADRs. Materials and Methods: A Cross-sectional Surveillance based study was carried out in Osmania medical college and affiliated hospitals, for 2-months duration among 160 Clinicians. The questionnaire consists of 4 questions and the participants were informed to provide their feedback. Data was collected and analyzed using SPSS version 25 software. Results: Only150 clinicians responded. 98.6% of Clinicians agreed to implement PvPI-Helpline (Toll-Free) number for quick reporting of ADRs.93.3% disagreed with creating a WhatsApp group for reporting ADRs as they taught it was not a secure platform to...
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Posted by admin on Sep 30, 2023 in |
This investigation evaluates the oral toxicity of Phaseolus vulgaris immature pods decoction a the biochemical, hematological, and cardiac profile of Wistar rats. Methods: The Economic Cooperation and Development Organization (OECD) guidelines 423 and 407 were applied. A 2000 mg/kg dose of PAD was administered to six female mice. Mortality, body weight, clinical signs of toxicity, food and water intake were recorded for 14 days. In the subacute oral toxicity test, daily doses of 100, 500, and 1000 mg/kg of PAD were administered to groups of five rats of both sexes for 28 days. Mortalities, clinical signs of toxicity, weight growth, water, and food intake were recorded throughout the period. Results: PAD did not cause mortality or significant clinical signs of toxicity at 2000 mg/kg bw. The LD50 of this extract was estimated to be 5000 mg/kg bw. All animals survived daily administration of 100, 500, and 1000 mg/kg of PAD decoction. The weight gain was comparable to that of the control groups in male and female-treated rats. Furthermore, no...
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Posted by admin on Sep 30, 2023 in |
A study was performed to develop a simple HPLC method for estimating sertraline Hydrochloride in unit dose. The method was created by evaluating the drug sertraline hydrochloride’s solubility in phosphate buffer, pH 4.0, at 254 nm. The chromatographic separation was accomplished on Prominence I LC 2030 C (Shimadzu Corporation, Japan). A 10 µl sample volume and a C18 column (250 x 4.6 mm (5 µm) were employed. The created and improved procedure produced the desired results. A 0.9998 linearity value was discovered. Buffer (Monobasic Potassium Phosphate of Buffer pH 4.0): Acetonitrile: and Methanol (50:25:25) were combined in a mobile phase designed for the technique at a 2.0 ml/min flow rate. Sertraline Hydrochloride was simultaneously identified at 254 nm with a retention time of 10.4±0.2 min. The percentage of the medicine was calculated using the specification limits after a quantitative assay of the commercial formulation. According to ICH guideline Q2R1, validation was completed successfully. The suggested approach can be used for a BE study to assess its applicability further and...
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