Posted by admin on Sep 1, 2012 in |
Non enzymatic glycation takes place when elevated levels of reduced sugars react with amino groups of proteins and is called as advanced glycation end products (AGEs) are responsible for Diabetes Mellitus. Hydroalcoholic extract of Whitton root (Eulophia nuda) was tested for in-vitro inhibition of non-enzymatic glycation of Immunoglobin G. Plant extracts have their own importance and now being studied extensively due to having little or no side effects in all aspects of life sciences from botany to medicine in biochemical research. In present study Whitton root was selected and used to check the glycation inhibitory activity in-vitro condition. Various combinations of glucose, protein and Whitton root extracts were made under in vitro conditions and their activity was monitored with Trichloro acetic acid treatment method at 350 nm. Glycated products/ AGEs were more with high glucose and high protein concentration and these were decreased by highest concentration of Whitton root extract i.e. 30 mg/mL or 300 μL. Lower concentrations of plant extract produced either no or least response against advanced glycation end products...
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Posted by admin on Sep 1, 2012 in |
Valsartan is an orally administered ACE inhibitor for the treatment of hypertension and cardiac failure, but its solubility and oral bioavailability are poor. The objective of investigation is to formulate a microemulsion drug delivery system of valsartan using minimum surfactant concentration that could improve its solubility and oral bioavailability. Valsartan microemulsion were prepared by Phase-titration method. The composition of optimized formulation consist of Capmul MCM(Oil), Tween 20 (Surfactant),PEG 400(Co-Surfactant) and it contains 40 mg of Valsartan.Pseudo-ternary phase diagrams were plotted to check for the micro-emulsification range. Prepared microemulsion formulations were tested for micro emulsifying properties and the resultant microemulsion were evaluated for robustness to dilution, viscosity, drug content, thermodynamic stability studies and in-vitrodissolution. The optimized microemulsion formulation further evaluated for thermodynamic stability studies, particle size distribution, and zeta potential to confirm the stability of the formed Microemulsion. Resultant microemulsion optimized formulation (F2) shows drug release (99.71%), droplet size (36 nm), viscosity (0. 8872 cP), Zetapotenial (-38.8 mV) and infinite dilution capability. The formulation was found to show a significant...
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Posted by admin on Sep 1, 2012 in |
Aim: To check the effectiveness of 0.15% Benzydamine hydrochloride on oral mucositis secondary to cancer chemotherapy Methods: In the past few years, multiple cases were referred to our department for the management of oral manifestations of cancer chemotherapy for various malignancies. Out of these patients, we selected 5 patients and used a simple, inexpensive treatment modality in consideration with patient’s affordability and convenience. They were prescribed 0.15% Benzydamine hydrochloride oral rinse (Tantum) for the relief of oral discomfort. Results: Significant reduction in oral mucositis and discomfort was observed after a week. The treatment was continued for 3 weeks till complete disappearance of oral ulcers. Conclusion: Benzydamine oral rinse is simple, effective, safe, inexpensive and well tolerated therapeutic modality for prophylactic and palliative treatment of chemotherapy-induced oral mucositis. It holds a special significance in the developing countries such as India for the lower socioeconomic...
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Posted by admin on Sep 1, 2012 in |
Tinospora cordifolia is known for a wide range of medicinal properties. In this study, cardiovascular and antimicrobial properties of aqueous and ethanolic extracts of Tinospora cordifolia were evaluated. Dose dependent negative ionotropic and chronotropic effects were observed with both aqueous and ethanolic extracts. The effects were antagonized by atropine indicating involvement of muscarinic receptors. Maximum antimicrobial activity was found with ethanolic extract of Tinospora cordifolia (15mm) against Pseudomonas aeruginosa. The organism showed resistance to aqueous extract giving an inhibition zone of 0.3mm. The data suggest that Tinospora cordifolia could be of benefit in arrhythmias and microbial infections....
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Posted by admin on Sep 1, 2012 in |
Tridax procumbens L. is a well known medicinal plant. In the present study alkaloids from pedicle and buds of the plant were extracted and evaluated for antimicrobial activity by ‘Disc Diffusion Assay’ against selected bacteria (Escherichia coli, Staphylococcus aureus and Proteus mirabilis) and fungi (Aspergillus flavus, Aspergillus niger, Candida albicans and Trichophyton mentagrophytes). Minimum inhibitory concentration, minimum bactericidal/fungicidal concentration and total activity of each active extract were also evaluated. Significant antibacterial activity was recorded by alkaloids of pedicle against P. mirabilis (IZ 20mm, AI 0.83 and same MIC, MBC 0.039 mg/ml) and antifungal activity was recorded by buds against C. albicans (IZ 9.2mm, AI 0.92, MIC 0.625 mg/ml and MFC 1.25 mg/ml). MIC ranged from 0.039 mg/ml-0.625 mg/ml and MBC/MFC ranged from 0.039 mg/ml-1.25 mg/ml against susceptible pathogens. It is noteworthy that MIC values of active extracts was found very low (0.039 mg/ml-0.625 mg/ml) and was recorded below 1 mg/ml against inhibited pathogens, thus ascertain their strong antimicrobial potential against selected microbes. Thus, the result of the present study...
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