Various 1-(substituted benzylidene)-5-(3-hydroxyquinoxaline-2-yl) carbonohydrazide were synthesized starting from orthophenylenediamine. Structures of all the compounds were confirmed on the basis of spectral analyses. All the newly synthesized compounds were screened for anticonvulsant activity. Some of the compounds showed significant anticonvulsant activity with no...
Read MoreCrossandra infundibuliformis belonging to family Acanthaceae is well known medicinal plant in various region of India. This plant is one of the most chosen variety for folk medicine. Flower extract used in various conditions like fever, headache, aperitif, pain etc. Present study is concern mainly with evaluation of wound healing activity of flower ethanolic extract in Wistar rats using excision wound model in the form of ointment using two concentrations (2 and 4%w/w ointment) of flower extract in simple ointment base. Both concentration of ethanolic extract showed significant response in both the wound type tested when compared with control group. 4% w/w concentration has showed better significant value than the standard drug. Nitrofurazone ointment (0.2%w/w) was used as standard...
Read MoreTrichosanthes dioica Roxb (family: Cucurbitaceae), commonly known as “Sespadula” in English and “Parwal” in Hindi and is widely grown throughout India. The leaves of this plant have also been used in traditional system of medicine for overcoming problems like constipation, fever, skin infection, wound healing and also in gastric ulcer. In the present study Aqueous extract of leaves of Trichosanthes dioica Roxb was evaluated for its antiulcer activity against; 1) Aspirin plus pylorus ligation model and, 2) Ethanol/HCl-induced ulcer in wistar rats. Ranitidine (100 mg/kg) was used as the standard drug. Different groups of rats (n=6 in each group) were given two doses (250 and 500 mg/kg) of T.dioica extract. Phytochemical analysis of the extract was also done. Phytochemical results revealed presence of tannins, saponins, triterpenoids, flavanoids. Thus only T.dioica extract (500 mg/kg) significantly (p<0.001) reduced the ulcer index in all the models used. The extract also significantly (p<0.001) increased the pH of gastric acid while at the same time reduced the volume of gastric juice, free and total...
Read MoreEthanol extracts of Naringi crenulata leaf and bark were evaluated for its anti-inflammatory activity at the dose levels of 250mg kg-1 and 500mg kg-1 body weight using a Carrageenan induced paw oedema method (acute inflammation). Results showed that both leaf and bark ethanol extracts had potent and significant anti-inflammatory activity. These results were also comparable with reference drug indomethacin used in this...
Read MoreAim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event similar to asthma. Results: The results demonstrated that the Sephadex induced lung inflammation and croton oil induced ear edema both were palliated by the Nyctanthes arbortristis leaf extract given to the rats. The prophylactic effect of the leaf extract was evaluated by the lung weight and histological examination and investigation of oxidative and anti-oxidant markers in lung tissues. Conclusions: This study demonstrated for the first time that ethanolic leaf extract of Nyctanthes arbortristis (ENAL), was effective in prevention of experimentally induced asthma in rats. In vivo data indicated that ENAL were as much effective as Fluticasone propionate i.e. standard drug used to treat asthma which might be...
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