Posted by admin on Aug 1, 2012 in |
The compound drug Jawarish-e-Bisbasa is a polyherbal Unani formulation. It is used in the ailments of general weakness of the stomach, flatulence in the stomach, indigestion, blind piles and nausea etc. Therefore the scientific validation for development of SOP, pharmacopoeial standards, TLC studies and safety parameter is very much essential to provide the quality medicine to the needy mass. The drug was prepared in different batches at laboratory scale using authenticated nine raw drugs. The present study was aimed to develop the SOP’s for the preparation of drug and to evaluate its pharmacopoeial parameters, estimation of heavy metals, microbial load, aflatoxins and pesticide residues. The obtained physicochemical data will help in laying down SOP’s and pharmacopoeial standards for this drug. Thin Layer Chromatographic studies of the drug will provide the finger prints which will help in quality control and detection of adulteration. The result of quality control parameters such as microbial load, aflatoxins, heavy metals and pesticide residue shows that the drug is free from toxic...
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Posted by admin on Aug 1, 2012 in |
The present study involves preparation of floating microspheres of Ranitidine Hydrochloride with Sodium alginate, Guargum and Xanthan using ionic gelation method. Floating microspheres were aimed to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The formulations were evaluated for FTIR, drug loading, % entrapment, particle size, SEM, buoyancy, dissolution study and the drug release kinetics. The enhanced floatability of the formulation and its retention in GIT may attribute for the increased bioavailability and decrease in frequency of administration. Comparison of three polymers revealed HPMC to be a suitable candidate for sustained...
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Posted by admin on Aug 1, 2012 in |
Aim: The aim of the study was to determine the prevalence, approach and behavior towards medication storage & self-medication practice amongst the youth in Karnataka, India. Methodology: A pre-cross sectional survey was conducted, administering a pre-piloted questionnaire among the target population. Sample size of 150 was analyzed using the percentage method. Results: Out of 150 respondents, 84.62% were found to store medications in their rooms. The prevalence of self-medication was 88.6%. The most common reasons for self-medication were: respondents’ knowledge about the illness & its treatment (47.06%), the time saving factor (44.12%), and prescriber’s ineffective medications (8.82%). Commonly stored medications included analgesics/anti-pyretic (28.07%) and anti-infectives (17.54%). Others included were ENT drugs (14%), Gastrointestinal (GIT) drugs (14%), skin products (6%), Vitamins (8%), ayurvedic medicines (10%), while remaining were categorized as miscellaneous (15.33%). Other considered parameters include: awareness about proper use & expiry dates, and storage & disposal condition. It was concluded that medication storage and self medication were highly prevalent among students. Discussion: There is an immediate need to educate...
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Posted by admin on Aug 1, 2012 in |
Matrix tablets of timolol maleate were prepared using hydrogel forming natural polysaccharides like sodium alginate, xanthan gum and guar gum alone and with hydrophobic polymers like ethyl cellulose and hydroxyethyl cellulose by direct compression method. The Fourier-transform infrared spectroscopy of drug-polymer and polymer-polymer was studied and revealed the compatibility of drug and polymer. All the precompression parameters like angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio for drug polymer mixture were found within limits of pharmacopeial specification. The tablets were studied for post compression parameters like hardness, thickness, weight variation and drug content were in acceptable range of pharmacopeial specification. The tablets were studied for invitro swelling index, invitro drug release study. The effect of hydrophobic polymers like ethyl cellulose and hydroxy ethyl cellulose were also studied on invitro swelling and drug release. The scanning electron micrography was done for selected swellable matrix tablets revealed that the tablets containing guar gum and hydroxy ethyl cellulose (F9) showed compact structure with fewer cracks. All the matrix...
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Posted by admin on Aug 1, 2012 in |
The crude ethanolic extract of the root of Lagenaria siceraria (Molina) Standley (Family: Cucurbitaceae), was evaluated for its possible anti-inflammatory activity and determination of total flavonoids and tannin contents growing in Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of the ethanol extract. At the dose of 400 mg/kg body weight, the extract showed a significant anti-inflammatory activity both in the carrageenan and histamine-induced oedema test models in rats showing 59.57% and 58.86% reduction in the paw volume comparable (P<0.01) to that produced by the standard drug indomethacin (63.12% and 66.45%) at 4h respectively. The percentage inhibition of the oedema paw volume by the 400 mg/kg body weight of the extract was also statistically significant (P<0.05; P<0.01) compared favorably with the indomethacin treated animals at 1, 2 and 3 h in both models. The total flavonoids and tannins content were calculated as quite high in ethanolic extract (244.29 mg/g of quercetin equivalent and 84.59...
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