Posted by admin on Jun 1, 2012 in |
Two triterpine acids like 2α, 19α- dihydroxy – 3-oxo-12- ursen- 28-oic acid (1), 2α, 16α, 19α- trihydroxy – 3-oxo-12- ursen- 28-oic acid (2) were isolated from the n-hexane soluble fractions of a methanol extract of the root of Albizzia lebbeck Benth. The structures of the isolated compounds were elucidated as by extensive spectroscopic studies, including high field NMR analyses. This is the first report of isolation of compounds 1- 2 from this...
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Posted by admin on Jun 1, 2012 in |
The aim of the present study is to formulate and evaluate controlled release formulation of lornoxicam based on osmotic technology. Lornoxicam, a potent non-steroidal anti-inflammatory drug (NSAID) with shorter half life, makes the development of sustained release (SR) dosage forms extremely advantageous. However, due to its weak acidic nature, its release from SR delivery system is limited to the lower GIT which consequently leads to a delayed onset of its analgesic action. Basic pH modifier tromethamine and wicking agent SLS were incorporated into the core tablet to create basic environmental pH inside the tablets, which provide complete drug release that starts in the stomach to rapidly alleviate the painful symptoms and continue in the intestine to maintain protracted analgesic effect. The effect of different formulation variables namely level of osmogen (mannitol) in the core tablet and level of pore former (sorbitol) in the coating membrane on in-vitro release was studied. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and level of osmogen...
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Posted by admin on Jun 1, 2012 in |
Daily oral administration of the total alcoholic extract and its ethyl acetate fraction of the bark of Cassia fistula in alloxan induced diabetic rats exhibited significant reduction in blood glucose levels and also found effective in restoring the blood lipids to normal levels. The activity was found comparable with standard drug glibenclamide. The ethyl acetate fraction showed more significant antidiabetic effect. The chromatographic isolation of ethyl acetate fraction summarizes the presence of flavonoidal...
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Posted by admin on Jun 1, 2012 in |
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of prednisolone acetate and ofloxacin in combined eye drop dosage form. The method is based on the simultaneous equations method for analysis of both the drugs using methanol as solvent. Prednisolone acetate has absorbance maxima at 243 nm and ofloxacin has absorbance maxima at 228 nm in methanol. The linearity was obtained in the concentration range of 5-17 μg/ ml and 1-13 μg/ml for prednisolone acetate and ofloxacin respectively. The concentrations of the drugs were determined by using simultaneous equations method at both the wavelength set 243nm for PRD and 228nm for OFL. The method was successfully applied to pharmaceutical dosage form because no interference from the eye-drop excipients was found. The suitability of this method for the quantitative determination of prednisolone acetate and ofloxacin was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of prednisolone acetate and ofloxacin in pharmaceutical...
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Posted by admin on Jun 1, 2012 in |
A simple, rapid, sensitive and cost effective difference spectrophotometric method have been developed for the determination of Febuxostat in its tablet dosage form. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their UV spectra. Difference spectrum, obtained by keeping Febuxostat in 0.1N NaOH in reference cell and same in 0.1N HCl in sample cell, showed two characteristic peaks at 260nm and 315nm with positive and negative absorbance respectively and viceversa. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The calibration curve is linear over the concentration range of 5-25 µg/ml (r2 = 0.999), with a detection limit of 0.58µg/ml. The method was successfully applied to the commercial pharmaceutical drug without interference from common ingredient accompanying the drug along with its dissolution profile and very cost effective as its prevents the use of hazardous and costly organic...
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