Posted by admin on Jun 1, 2012 in |
A new series of flurobenzothiazole incorporated 1, 3, 4 – thiadiazole compounds have been synthesized. The structure of the synthesized compounds was confirmed by UV, IR, 1H NMR, Mass spectral analysis and evaluated for their antimicrobial activity against Proteus vulgaris NCTC 4635, Micrococcus leutus NL98, Aspergillus flavus ATCC 46646by disc diffusion method. The compounds SH8 and SH11 were also evaluated for the anti-inflammatory activity by carrageenan-induced paw oedema method. The synthesized compounds (SH6 to SH11) showed good antimicrobial activity. However the antimicrobial activity of the synthesized compounds against the tested organisms was found to be less than that of respective standard drugs used at tested dose level. The anti-inflammatory activity confirmed that the test compound SH11 showed superior activity in the inhibition of oedema than SH8. However, both the test compounds were found to be less active than the standard drug...
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Posted by admin on Jun 1, 2012 in |
A new, simple, sensitive and reproducible spectrophotometric method has been developed for the estimation of Flucloxacillin in pure form. Method involves the determination of Flucloxacillin by dissolving in water and followed by measuring the absorbance at 273 nm. The linearity was obtained in the concentration range of 100-300 µg /ml. The suitability of method for quantitative analysis of Flucloxacillin was proved by validation. This method was extended to tablet formulation and there was no interference from excipients and diluents. This method has been statistically validated and is found to be precise and...
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Posted by admin on Jun 1, 2012 in |
Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poorly water soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Most of the drugs are weakly acidic and weakly basic with poor aqueous solubility. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilization, hydrotropy etc. The purpose of this work was to describe the enhance solubility of rifampicin by using solid dispersion technique and Physical mixture with PEG6000. Here drug and carrier ratio 1:1, 1:2, 1:3 and 1:10 respectively. The prepared samples were evaluated by SEM, Drug content, In-vitro studies, Wettability and Solubility, IR studies, Angle of repose. In-vitro drug release showed fast and complete release over a period of 2hrs...
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Posted by admin on Jun 1, 2012 in |
Phellinus and Ganoderma are a folk medicinal, wood inhabiting fungus, recently been studied for its pharmacological activities. In the current study, Acetone, Methanol and ethyl acetate extracts were prepared from species of Phellinus and Ganoderma. The active compounds of acetone and methanol extracts have the same polarity but they show different activity. The antimicrobial assay showed zone of inhibition against different strains of Acinetobacter and acetone extract gave best results. Therefore, the extract of Phellinus may contain different bioactive compounds like sesquiterpens, triterpens etc that may act on Acinetobacter. A significant broad spectrum anti-bacterial activity from Phellinus spp. was revealed through the...
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Posted by admin on Jun 1, 2012 in |
Candida albicans is one of the most important fungi associated with oral candidiasis and the treatment of this fungi is a serious problem today because of the resistance of these fungi against conventionally used drugs. So, there is an urgent need of alternative antifungal substances especially from the natural sources. The study was conducted to examine the MFC and time kill activity of two stilbenes [3, 4′, 5-trihydroxystilbene (1) and 3,5-dihydroxy-4-isopropylstilbene (2)] purified from a bacterium associated with entomopathgenic nematode against C. albicans. The activity was also compared to amphotericin B. The cytotoxicity of stilbenes was also tested against normal human cell lines (L231 lung epithelial and FS normal fibroblast). Results showed that stilbenes was effective against C. albicans with MIC and MFC of 64 and 128 µg/ml for compound 1 and 32 and 64 µg/ml for compound 2. The time kill assay of stilbenes against C. albicans was more effective than amphotericin B. No cytotoxicity was recorded for stilbenes upto 200 µg/ml. The strong antifungal activity and low...
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