Posted by admin on Jun 1, 2012 in |
Typhoid fever is serious public health problem in many parts of the world.Typhoid fever, also known as enteric fever, is an illness caused by the bacterium, Salmonella typhi. The immunology of typhoid fever in man has been the subject of a recent review. The diagnosis and subsequent treatment could reduce infection complication towards acute illness. It is difficult at present time, to diagnose typhoid fever early in its course. The immunological assay can be designed for the earlier detection. The detection of specific bacterial antigen from body fluid and serum was suggested to be an important diagnostic method in infections disease. The EIA i.e., Enzyme Immuno Assay can be carried out which is found to be very significant. The results are discussed here in relation to the concept of detection of fever in early...
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Posted by admin on Jun 1, 2012 in |
The study was aimed to evaluate the anticancer activity of the Soft Halicona species on the HeLa cell line. The Soft Halicona species methanol and Dichloromethane extracts were tested for its inhibitory effect on HeLa cell line. The percentage viability of the cell line was carried out by using colorimetric method. The cytotoxicity of Soft Halicona specieson HeLa cell was evaluated by MTT assay. Both the methanol and Dichloromethane extract has significant cytotoxic effect on HeLa cell line in concentration range between 0.1µg/ml to 100µg/ml by using MTT assay. R2 value of Soft Halicona species on HeLa cell of methanol extract was 0.8316 and for dichloromethane extract was 0.6699 and percentage cell inhibition for methanol extract 61.40% and Dichloromethane extract was 46.98%....
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Posted by admin on Jun 1, 2012 in |
The regulatory authorities are now focusing on the regulatory issues of traditional medicines under which Unani system of medicine falls. Today we are witnessing an increase in the use of traditional medicines throughout the world raising the questions as to how safe these preparations are. People are now bending towards the Unani system of medicine because of its safety, efficacy and lesser side effects and hence raising the popularity of the Unani system of medicine. The major problem associated with Unani system of medicine is the lack of regulatory issues that ultimately leads to counterfeiting of Unani medicines. In the present article an endeavour has been made to present an overview of Unani system of medicine with special attention towards the Unani Cosmeceuticals products. This article intends to contribute towards the regulatory knowledge by giving a survey of published information regarding the regulations of the Unani Cosmeceuticals products. This article also focuses on the good manufacturing practices along with the standards for Unani Cosmeceuticals drug contents. This present article...
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Posted by admin on Jun 1, 2012 in |
Controlled porosity osmotic tablet of metoprolol succinate prepared and evaluated in this study. Metoprolol succinate is very high soluble drug, so complete drug release obtained very fast. It is difficult to formulate osmotic tablet of Metoprolol succinate which gives drug release up to 24 hr at zero order. To get desired dissolution profile various formulation parameters like osmogen concentration, level of weight gain and level of pore former concentration were studied. Hypromellose was added as release retardant to reduce its dissolution rate and get drug release up to 24 hr at zero order. As concentration of release retardant increases, dissolution rate decreases. Final optimized formulation with hypromellose was studied for effect of pH of dissolution media, agitation intensity and osmotic pressure of dissolution media. There is no effect of above variables on dissolution confirms that prepared metoprolol succinate tablet gives drug release with osmotic mechanism. Final optimized formulation complies with the USP criteria for the dissolution of metoprolol succinate extended release...
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Posted by admin on Jun 1, 2012 in |
A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Azithromycin dihydrate and Cefixime trihydrate in combined dosage form. Second order derivative spectroscopy method is adopted to eliminate spectral interference. The method obeys Beer’s Law in concentration ranges of 10-40 ppm for Cefixime trihydrate and 25-100 ppm of Azithromycin dihydrate. The method was validated for linearity, accuracy and precision as per ICH guidelines. The zero crossing point for Azithromycin dihydrate and Cefixime trihydrate was 326.4 nm and 226.8 nm, respectively in water. The LOD and LOQ value were found to be 0.54 and 1.64 ppm for Cefixime trihydrate and 0.77 and 2.34 ppm for Azithromycin dihydrate respectively. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form (ZIMNIC...
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