Posted by admin on Aug 1, 2012 in |
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery...
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Posted by admin on Aug 1, 2012 in |
The present study describes the antifungal activity of Durenta erecta L. against some phytopathogenic fungi: Aspergillus niger, A. flavus, A. fumigatus and Penicillium sp. For this purpose, methhanolic extract of leaf, stem and root were prepared and tested by “Disc Diffusion Method”. The methanol extract was subjected to preliminary phytochemical analysis. Alkaloids, saponins, and polyphenols (tannins and flavonoids) were detected as phytoconstituents of the methanol extract. As a result of antifungal activity it was found that the extract of leaf generally revealed antifungal activity against all Aspergillus spp. but activity was highest against A. fumigatus (20±0.67 mm). Stem extract showed less activity against all test fungi but no activity against A. flavus. Root extract did not show any antifungal activity except A. fumigatus with less activity...
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Posted by admin on Aug 1, 2012 in |
Metabolic syndrome (MetS) is a clustering of metabolic abnormalities that has close association with cardiovascular mortality. MetS has becoming a major challenge for public health. To get insight knowledge about the MetS in diabetes, this population-based study was designed. Here we assessed the MetS in diabetes from a coastal region of Bangladesh. MetS was estimated by using the modified definition of the National Cholesterol Education Program Adult Treatment Panel III. A total of 500 patients visiting to a diabetic clinic were included in this study. Anthropometric, clinical and biochemical data were recorded. Our result revealed that, about 47.00% patients with type 2 diabetic mellitus were suffering from metabolic syndrome. Female were more prevalent than male (58.6% vs 36.14%) for suffering from MetS. Among other risk factors for MetS, obesity and hypertriglyceridemia followed by low-HDL were more prevalent in female. In contrast, male were more likely to have low-HDL and hypertriglyceridemia followed by high blood pressure. Since diabetic patients are more porn to suffer from MetS, and it becomes a...
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Posted by admin on Aug 1, 2012 in |
The present study was designed to evaluate antidiabetic effects of ethanolic extract of Semecarpus anacardium (SA) stem barks in normal and alloxan induced diabetes rats. The antidiabetic effect of extract was evaluated investigated by measuring fasting blood glucose level and oral glucose tolerance test (OGTT) in normal and alloxan induced diabetes animal models. Here metformin (150 mg/kg) was used as reference drugs for comparison. The extract significantly (P<0.05) reduced blood sugar level in alloxan induced diabetic (hyperglycaemic) and glucose induced hyperglycemic (normo-hyperglycaemic) rats when given orally at doses of 200 mg/kg and 400 mg/kg body weight respectively. The glucose tolerance results showed the ethanolic extract significantly improved 55% and 68% at the dose of 200 mg/kg and 400 mg/kg body weight (b. wt.) whereas metformin showed 80% of that. The phytochemical screening of the plant S. anacardium stem bark showed the presence of steroids, triterpenoids, flavonoids, glycosides, saponins and tannins. However a glucose tolerance hypoglycemic test is comparable to diabetic control group and effect is a dose dependent. The...
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Posted by admin on Aug 1, 2012 in |
Corchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% respectively. Its pharmaco-technical properties: friability, hardness, weight uniformity, disintegration time, percentage of fines, and angle of repose, were determined and compared with that of paracetamol produced from a commercial binder- Sodium carboxymethylcellulose (SCMC). The results obtained showed great promise and a comparative efficacy between the gum extract obtained from Corchorus olitorius L. and the...
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