Posted by admin on Aug 31, 2025 in |
Tuberculosis (TB) continues to rank among the world’s most serious health problems despite the remarkable biomedical achievements. The objective of the study is to describe and characterize the adverse drug reactions associated with Anti Tubercular Therapy (ATT) in a tertiary care hospital. This was a cross sectional study done in the Department of Thoracic medicine, Government Medical College Krishnagiri between May 2023 and July 2023(3 months). Around 240 patients taking anti-tubercular drugs were screened and 98 patients (40.8%) among them were found to have adverse reactions to the therapy. Incidence of ADR was highest (8.3%) among (21-30) and (51-60) age groups. Among the type of detected adverse drug reactions induced by anti-TB drugs, gastritis (8.3%) was the most common, followed by rash (5%), hepatitis (4.2%) with hard of hearing (0.8%) and vision abnormality (0.8%) being the least common. Causality assessment revealed around 64 ADRs (26.7%) had possible relation to the drug usage. severity assessment of ADRs induced by ATT revealed mild in 52 patients (21.7%), moderate in 44 patients...
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Posted by admin on Aug 31, 2025 in |
The current research is to develop an easy and eco-friendly method for synthesizing Flower silver nanoparticles [FAgNPs] and Stem silver nanoparticles [SagNPs] using an aqueous extract of flower and stem Leonotis nepetifolia, (L.) R. Br. (family: Lamiaceae), and to evaluate their antibacterial properties. The obtained sample of synthesized FAgNPs and SAgNPs were characterized by UV–vis spectrophotometer, Zeta potential, X-ray Diffraction [XRD], Field Electron- scanning electron microscope [FE-SEM], and Fourier transform infrared spectroscopy [FT-IR] analysis. The formation of FAgNPs and SAgNPs was confirmed by the observation of band between 300 nm to 700 nm UV–vis spectrum. The crystalline structure of FAgNPs and SAgNPs with a face- centered cubic (FCC) was confirmed by XRD. The responsible phytochemicals for the reducing and capping agents of FAgNPs and SAgNPs were observed with FT-IR spectra analysis. The FE-SEM monograph revealed the spherical shape and size of FAgNPs and SAgNPs. Hence synthesized AgNPs were found to be in nano size and stable. Furthermore, the biosynthesized FAgNPs and SAgNPs indicated adequate antibacterial activity against clinical pathogen,...
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Posted by admin on Aug 31, 2025 in |
The objective of the present study was to develop a time-controlled floating pulsatile drug delivery system of Ritonavir (RIT), an antiviral drug with low oral bioavailability due to degradation by CYP3A4 enzymes, efflux by P-glycoprotein, and instability at alkaline pH. Ritonavir is primarily absorbed in the stomach; hence, a floating pulsatile release system was designed to enhance absorption and therapeutic efficacy. Core tablets of Ritonavir were prepared using different superdisintegrants and evaluated for in-vitro disintegration. The disintegration time varied from 21–44 seconds, with crosspovidone showing the fastest disintegration due to rapid water penetration compared with croscarmellose sodium and sodium starch glycolate. Since rapid disintegration is critical for burst release, the F3 formulation was selected for further studies. The rapid release core tablet (F3) was compression-coated with varying concentrations of HPMC K4M, HPMC K15M, and HPMC K100M (P1–P9). Formulations with HPMC K100M (P7–P9) showed a lag time of 4–4.5 hours followed by sigmoidal release, achieving 100% drug release by 10–12 hours. Among these, P9 (core 100 mg + 180 mg...
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Posted by admin on Aug 31, 2025 in |
Amoxicillin is an antibiotic beneficial for the treatment of some bacterial infections. When orally administered it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Amoxicillin and produce sustained drug delivery. Microspheres can be manufactured from various natural and synthetic materials. In these 14 batches of Amoxicillin, microspheres were prepared using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were evaluated for different parameters i.e % drug yield, % drug entrapment, shape, surface morphology, particles size, polydispersity index, zeta potential and in-vitro drug release for 48 hours in phosphate buffer 7.4. The best batch performed stability studies for 6 months. The research concluded that Amoxicillin microspheres could be an alternative for conventional dosage form and other phytochemical in herbs. The optimized formulation was found with significant loading...
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Posted by admin on Aug 31, 2025 in |
Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habits convert to diseases like obesity, type 2 diabetes mellitus (T2DM), dyslipoproteinemia etc. This case-control study was carried out in the Department of Biochemistry in collaboration with the Department of General Medicine, Madhav Prasad Tripathi Medical College, Siddhartnagar to explore the status of blood sugar fasting (BSF), tumor necrosis factor-α (TNF- α), Insulin, Insulin resistance, antioxidant enzymes and lipoprotein profile by standard spectrophotometric kit methods, as well as anthropometric measurements, blood pressure (BP) with the help of suitable instruments and equipment’s in Control group and Obese with T2DM group. A marked impairment observed in levels of lipoprotein profile accompanied by an increase in the lipids and apo-protein levels of serum β lipoproteins, lipid peroxide, Insulin and Insulin resistance, blood pressure, anthropometric measurements following the decrease in lipid and apo-protein constituents of α lipoprotein. Also...
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