Posted by admin on Feb 28, 2025 in |
Uraria picta (family Fabaceae) is an important woody medicinal herb. This plant has been used in traditional systems of medicine for the treatment of various diseases. It is also used in an Ayurvedic formulation of “Dashmula”. The utilization of roots by uprooting the entire plant and the problems associated with seed germination threaten this plant in its natural habitat and cause a shortage of root material for Ayurvedic preparation. The present study aimed to assess seed viability and the influence of pre-sowing treatments on seed germination and seedling development of U. picta. The treatments were applied singly and in combination, including acid scarification (H2SO4), hot and rubbing with sandpaper, pre-soaking in gibberellic acid (GA3), and the application of cuttings to the seed coat followed by pre-soaking in distilled water. The significantly highest rate (90%) of seed germination and a higher proportion of strong seedlings were observed in the seeds treated with 95% H2SO4. The protocol developed for seed germination and seedling development can be applied for raising a large...
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Posted by admin on Feb 28, 2025 in |
Background: Plants for remedial applications are well known, realizing the pharmacological potentials of plants through analytical techniques. Asparagus racemosus is a well-known medicinal plant analyzed using biological approach. The present study was carried out to evaluate the antioxidant, ani-inflammatory, antibacterial effects and the possible bioactive compounds present in the chloroform, methanol and aqueous extract of A. racemosus plant. Methods: The whole plant was subjected to serial solvent extraction using chloroform, methanol, and aqueous. Phytochemical screening, total phenolic and total flavonoid contents were determined using standard methods and was followed by GCMS and FTIR for biological activity of compounds. The plant extracts were assessed for antioxidant activity by DPPH and FRAP assays, anti-inflammatory activity by protein denaturation method, and antibacterial activity by agar well diffusion method. Results: The phytochemical tests revealed the presence of phytochemicals like alkaloids, flavonoids, glycosides, triterpenoids, and saponins. The GCMS of whole plant chloroform, methanol and aqueous extract revealed the compounds that are rich in free radical scavenging activity and proven to be the best source...
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Posted by admin on Feb 28, 2025 in |
Discovering Novel MAO-B inhibitors is promising therapeutic strategy for Parkinson’s disease. The pharmacological effects of MAO-B inhibitor showed significant neuro-protection and improved motor function and reduced oxidative stress marker. In-silico molecular docking simulation to investigate the interaction between target protein (MAO-B Inhibitors) and revealing promising hits with high binding affinity and favorable interactions. Molecular docking and binding affinity were analyzed between protein MAO-B inhibitor with selected bioactive compounds and Synthetic drugs in order to find the most potential inhibitor against the target. Thus, the objective of this research can provide an insight comparision based prediction towards some bioactive compounds in Genus momordica species (folic acid, momordicin, Balsaminol-A, Karavilagenin-C, Beta carotene) and few synthetic drugs (Opicapone, Apomorphine, Selegiline, Rasagiline, Ladostigil Zonisamide, Safinamide, NSAID, RG-2833 (gene therapy drug) against MOA-B Inhibitors performed using Pubchem, ProteinDataBank, Biovia discovery studio and PyRx. This research focuses on docking between the potential bioactive compounds shows strong affinity towards the targeted MOA-B inhibitor protein to treat parkinson’s diseases compared to synthetic drugs. This study shows the...
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Posted by admin on Feb 28, 2025 in |
Giving birth is the most physically exhausting experience for a woman’s body. Tribal societies use medicinal plants and nutrient-dense foods as natural remedies to boost vitality, facilitate healing, and increase milk supply after delivery of women. The present study was carried outinthetribal-dominated areas of southern Rajasthan, including Banswara, Chittorgarh, Dungarpur, Pratapgarh, Udaipur, and certain parts of Sirohi District. During the study, group discussions and interviews were done with the active participation of local women, health practitioners, and elders known as dais or gunis, who are experts in delivering traditional health care services to lactating mothers in the research area. In the present study, 11 plant species from 9 families were reported as being used to boost milk production and support postpartum recovery by tribal women. The study revealed significant and vital information on the diversity of medicinal plants used by various traditional practitioners in postnatal care, which can be further integrated into the modern healthcare system to improve the health status of lactating women...
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Posted by admin on Feb 28, 2025 in |
Cadmium (Cd) is the seventh most toxic heavy metal; a potentially hazardous metal found that has a substantial impact on the peripheral (PNS) and central nervous systems (CNS). This study is aimed at investigating the concommitant administration of ethanol leaf extract of Anacardium occidentale (AO) and ripe Musa sapientum (MS) peels on fine motor functions in Cd-induced neurotoxicity in female wistar rats through. 30 adult female wistar rats (75 – 154 g) were used for this study. They were divided randomly into six groups (n=5). Group 1 (Control) received 1mL of distilled water. Group 2, 3,4 and 5 were treated with 100 mg/kg of Cd, 2.5 mg/kg of Donepezil, 200 mg/kg AO and 200 mg/kg MS respectively. Group 6 was co-treated with 200 mg/kg of AO and 200 mg/kg of MS for 21 days. Animals were then subjected to Neurobehavioural experiment using wire hang test for assessment of muscular strength. Biochemical assay for the assessment of Interleukin-6 (IL-6) and histological analysis of the cerebellum was done. The result of...
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