Posted by admin on Jul 31, 2023 in |
The present study aimed to determine secondary metabolites, in-vitro antioxidant, and antiulcer activities using various solvent-based Muehlenbeckia platyclada extracts. Solvents based phylloclade extraction was used to determine various secondary metabolites such as phenols, flavonoids, terpenoids and tannins and to assess in-vitro antioxidant activities such as DPPH, ABTS.+, superoxide, hydrogen peroxide, nitric oxide, FRAP, Phosphomolybdenum, metal chelating and reducing power activities. Further, in-vitro antiulcer activities such as α-chymotrypsin enzyme, urease enzyme inhibitory activity, H+ K+ ATPase activity and acid neutralization capacity (ANC) were performed, and the resultant was analyzed using response surface methodology (RSM) to develop an adequate functional relationship between a response of interest (ME) with independent variables (Time, HCL consumed and NaOH consumed). A correlation coefficient was made between secondary metabolites and in–vitro antiulcer activities. Methanolic extract (ME) showed higher levels of secondary metabolites, in–vitro antioxidant activities and was subsequently selected to evaluate its antiulcer potential. A significant inhibition for alpha chymotrypsin (88.84%), urease (68.52%), and H+K+ ATPase (91.75%) was compared with respective standards. RSM results of ME...
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Posted by admin on Jul 31, 2023 in |
Background: Geriatrics refers to the population of 60 years and older. The geriatric population is considered a significant consumer of prescription medications. Polypharmacy is a global phenomenon, and on the elderly population, the impact of polypharmacy is substantial. Aging is a multidimensional process, and it is a growing concern. Multiple comorbidities are one of the reasons for polypharmacy. Comorbidity is associated with more complex clinical management and the increase of drug use, and health care costs. In older adults, Drug-drug interactions have potentially life-threatening consequences. Methods: A prospective observational study was carried out for six months in a private corporate hospital in Secunderabad, Hyderabad. The data on patients aged 65 years and above who are hospitalized with comorbid conditions is collected from case sheets. Data includes socio-demographic details, number of medications, name of medications and comorbidities. Results: A total of 300 patients were included in the study. Polypharmacy was seen in 217 (72%) prescriptions and non-polypharmacy was seen in 83(27%) prescriptions. A total of 168 comorbid conditions were found...
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Posted by admin on Jul 31, 2023 in |
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin’s stratum corneum pores that are smaller than its size. The major goal of the transferosome in treating the condition psoriasis is drug penetration through the skin. However, the stratum corneum is the most formidable defence against drug penetration via the skin. In order to assist penetrate the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has attracted increasing interest in recent years. The current study set out to statistically improve the vesicular formulations (Transfersomes) of a model medicine, boswellic acid which is obtained from Boswellia serreta known as for the treatment of...
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Posted by admin on Jul 31, 2023 in |
The Present study was planned to gauge the immune-modulatory activity of the ethanolic extract and the isolated compound Stachydrine from the leaves of Capparis sepiaria L. (Capparidaceae). The study was extended to research the chemical compounds within the EECS (Ethanolic Extract of Capparis sepiaria). The preliminary phytochemical screening revealed that EECS evidenced the presence of varied phytoconstituents like alkaloids, glycosides, reducing sugars, flavonoids, saponins, starch and terpenoids. The alkaloidal compound Stachydrine was isolated and further evaluated by using UV, IR and NMR. Both in-vitro and in-vivo studies were administered to gauge the immunomodulatory effect of ethanolic extract of C. sepairia and the isolated alkaloid Stachydrine using Phagocytosis and Jerne plaque assay. Both ethanolic extract (25.82% for 70mcg/ml) and the isolated compound (21.28% for 25 mcg/ml) showed the enhancement of phagocytic index compared to regulate (18%) also because the number of plaques proportional to the amount antibody-producing lymphocytes within the cell population after the treatment with extract of C. sepiaria (551.25± 4.26 and 620 ± 7.25 for the 100mg/kg and...
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Posted by admin on Jul 31, 2023 in |
A number of the population in developing countries use herbs and herbal products to treat various diseases including malaria. However, most of them have not been evaluated for their efficacy and toxicity and their use is not standardized in some instances. Poly-herbal extracts may yield better treatment outcomes compared to extracts from a single plant due to the combined effects of bioactive compounds from the multiple sources. Cassia obtusifolia and Hyptis suaveolens are two plants commonly used in herbal preparations for treating malaria in Ghana. This study was to investigate Plasmodium falciparum asexual growth inhibitory activities of the individual and combined leaf extracts of the two plants. Leaves of the C. obtusifolia and H. suaveolens were extracted separately with methanol, ethanol and water. The six extracts, as well as in combination were evaluated in a dose-dependent manner for their antiplasmodial activities against the chloroquine-sensitive Plasmodium falciparum 3D7. Aqueous extract of C. obtusifolia, including the mixture of the two plants were highly active with mean IC50 less than 4.0 µg/mL....
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