Posted by admin on Apr 1, 2012 in |
Euphorbia prostrata Ait.(Euphorbiaceae) is a small, prostrate, annual green herb sometime purple tint in colour. It is widely distributed globally and used as antihemorrhoidal, anti-inflammatory, analgesic, hypolipidemic, antidiabetic, antidirroheal, antiasthmatic and for various skin diseases. The microscopy of root shows the presence of obliterated cork cells, phelloderm, cortex, endodermis, phloem, medulary rays and xylem; the stem shows the presence of multicellular trichome, cuticle, epidermis, cortex, endodermis, pericycle, phloem, latex canal, xylem and pith; the leave reveal the presence of multicellular, multiseriate glandular hairs, epidermis, vascular bundles, stomata anomocytic and anisocytic. The vein islet number and vein termination number have also been determined. The powder study reveals the presence of epidermal cells, trichomes, parenchymatous cells, pollen grains, vessels, fibers and stomata. The water soluble, alcohol soluble and petroleum ether extractive values were determined. The total ash, water soluble ash, acid insoluble ash and sulphated ash were also observed. Preliminary phytochemical studies revealed the presence of flavonoids, tannins, glycosides and saponins in the alcoholic extract of the plant. This is the...
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Posted by admin on Apr 1, 2012 in |
The Tin based herbal drug (Vangaparpam – a Siddha system of Medicine) has been widely used for the treatment of urinogenital infection and Arthritis. It was prepared by ten sequential stages of calcinations of the medicinally purified tin along with Aloe vera extract. In this study we analysed samples from various stages of preparation using analytical techniques viz., Fourier Transformed Infrared spectroscopy, Powder X ray Diffraction, X ray Photoelectron Spectroscopy, Energy Dispersive X- ray spectroscopy , Scanning Electron Microscopy, to create fingerprints required for the optimisation of the process parameters, detection of toxic impurities and crystal morphology of the Active Pharmaceutical ingredient during the formulation of drug for which reports are not available. Upon analysis of the samples of various stages of calcinations, we found that there was a programmed heating the medicinally purified tin metal was converted to crystalline tin oxide in the tetragonal phase at the first stage of calcinations itself along with a small percentage of therapeutically important elements of Calcium, Iron, and Potassium. Further calcinations...
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Posted by admin on Apr 1, 2012 in |
Drug delivery is the most essential feature in drug administration facility and the design of Nanosystems makes the action more consistent an appropriate. Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. In most cases (conventional dosage forms), only a small amount of administered dose reaches the target site, while the majority of the drug distributes throughout the rest of the body in accordance with its physicochemical and biochemical properties. Therefore, developing a drug delivery system that optimizes the pharmaceutical action of a drug while reducing its toxic side effects in vivo is a challenging task. This study focuses on the preparation and characterization of biopolymeric alginate and chitosan nanoparticles for encapsulating the antidepressant drug Venlafaxine XR and analyzing it as an effective drug carrier and delivery system. The study reports a method to predict the encapsulation efficiency of chitosan as an effective biopolymer....
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Posted by admin on Mar 1, 2012 in |
Comparative study of free radical scavenging activity and phenolic acid content of Bulgarian endemic Alchemilla jumrukczalica and the commercial herbal – Alchemilla vulgaris complex was carried.The methanol extracts of studied samples showed significant antiradical activity. The concentration of the extracts needed for 50% inhibition of DPPH was found to be 12,09 µg/ml and 19,62 µg/ml for A. jumrukczalica and A. vulgaris complex, respectively.Ten free and seventeen bonded phenolic acids were identified and quantified by performed of gas chromatography mass-spectrometry (GC-MS). Gentisic, protocatechuic, salicylicand trans-cinnamic acids were represented in the greatest quantityamong the identified phenolic acids. This is the first detailed analysis on qualitative and quantitative composition of phenolic acids inAlchemilla...
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Posted by admin on Mar 1, 2012 in |
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Atorvastatin Calcium, Olmesartan Medoxomil, Candesartan, diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (Length 150 mm × Diameter 4.6 mm Particle size 5 μm) column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 consisted of 0.05 M sodium dihydrogen phosphate buffer and acetonitrile (Gradient ratio). The UV detection was carried out at 220 nm. The method was successfully validated in accordance to ICH guidelines. Further, the validated method was applied for commercially available pharmaceutical dosage...
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