Posted by admin on May 1, 2012 in |
The curative parts of medicinal plants are not simply its woody stem or its leaves but the number of chemical compounds (phytoconstituents) it produces and uses for its own growth like flavonoids, alkaloids, gum, mucilage, protein, carbohydrate etc. The genus Phyllanthus is widely used in medicine but still lot of work left to explore this genus. So the species, Phyllanthus emblica which is widely used in Indian traditional system are selected for various screening. The mentioned plant materials are rich source of polyphenolic compounds and some typical type of polyphenolic are responsible for various pharmacological activities. The isolation and characterization of Phytoconstituents was done from the alcoholic extract by the chromatographic method. The structure of the isolated compound was established on the basis of physical, chemical test and spectroscopic evidences (IR, UV, 1HNMR, MS). A flavonoidal structure was isolated from the alcoholic extract of the plant. The yellow colored compound which solubilizes in methanol, ethanol and water having m.p. 315oC and Rf value 0.19 in mobile phase Isopropanol: formic...
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Posted by admin on May 1, 2012 in |
Two chemical compounds have been isolated and their structures were elucidated by spectroscopic studies including VLC, TLC and NMR. The isolated compounds are Ortho-hydroxy-N- benzyl- 16- Methyl- 11, 14- diene-octadecamide (1) and 9, 12-diene–octadecanoic acid...
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Posted by admin on May 1, 2012 in |
Mycotic infections of skin are caused by dermatophytes. Screening of plants for anti dermatophyte activity was carried out based on the literature search done. Native plants of Maharashtra (India) were screened for anti dermatophyte activity. Various plant parts from different regions were collected and then extracted with three different solvents viz. alcohol, hydro-alcohol and aqueous. The obtained extracts were subjected for anti dermatophyte activity using agar-well diffusion technique. Three different concentrations of extract were checked for activity. Two species of dermatophytes, viz. – Trichophyton and Microsporum were used in the screening assay. Out of the twenty-eight plants screened by agar diffusion method, seven were found to be active with different activity profile. Methanol extract was the most active extract. Pterospermum suberifolium, Trachyspermum ammi, Peltaphorum pterocarpum, Ixora coccinia, Persicaria glabra, Terminallia elliptica and Cicca acida showed activity at different concentrations against the two species of dermatophytes. The data obtained can be used for further studying the anti dermatophyte potential of active...
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Posted by admin on May 1, 2012 in |
The objective of present study is to evaluate the anti ulcer activity of methanolic extract of leaves of Aegle marmelos. The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanolic extract of Aegle marmelos leaves was investigated by aspirin plus pylorus ligation induced gastric ulcer in rats, Indomethacin induced ulcer in rats, water immersion stress test induced ulcer in rats. In aspirin plus pylorus ligation model, Aegle Marmelos at doses of 200 and 400 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. In Indomethacin and water immersion stress test induced ulcer models both doses (200mg/kg & 400mg/kg) of Aegle marmelos extract significantly reduced severity of ulceration. This present study indicates Aegle marmelos leaves extract have potential anti ulcer...
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Posted by admin on May 1, 2012 in |
A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadotril in bulk and tablet formulations. The method was linear (r=0.9998) at concentrations ranging from 8 to 100 µg ml-1, precise (repeatability and intermediated precision), exact (method of standard addition), and Limit of detection µg ml-1 (0.088749). Limit of quantification µg ml-1 (0.268938) was found and the % recovery is found...
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