Posted by admin on Sep 1, 2011 in |
Labetalol Hydrochloride due to its pH dependant solubility in range of 6-10 shows 10-80% variability in bioavailability, used in treatment of hypertension. Due to its short half life i.e. 3-6 hrs, it is administered twice a daily. Therefore to improve bioavailability and patient compliance in this study attempt has been made to develop an oral floating tablet of Labetalol hydrochloride. An optimized floating drug delivery system (GFDDS) of Labetalol Hydrochloride was developed using simplex Centroid design. In this design Hydroxypropyl methyl cellulose K4M (X1), Carbopol 934P (X2), Sodium carboxymethylcellulose (X3) were used as independent variables and floating lag time,t50% and t80% as responses. In this design effervescent matrix tablets were prepared by combination of citric acid and sodium bicarbonate. Results of ANOVA indicated, low levels of X2 and X3, and high level of X1 should be used to manufacture the tablet formulations with desired in vitro floating time, t50% and t80%. Kinetics of drug release from tablet followed Korsmeyer–Peppas model by anomalous non-Fickian diffusion. It was concluded that gastro...
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Posted by admin on Sep 1, 2011 in |
The antibacterial activity of methanol extract of Borassus flabellifer L. (Arecaceae) seed coat (soft outer shell) was studied by agar well diffusion method in vitro. The tender seed coat of Borassus flabellifer was extracted with methanol. The effect of antibacterial potential was examined against Gram positive bacteria i.e., Staphylococcus aureus, Bacillus subtilis and Gram negative bacteria i.e., Klebsiella pneumoniae and Serratia marcescens. The methanol extract of the seed coat has showed consistently significant inhibitory activity on different bacterial species tested. Furthermore, the minimum inhibitory concentration studies carried out by broth dilution assay and found the MIC ranged between 100μg to 1 mg/ml implying the significance of antibacterial activity of Borassus...
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Posted by admin on Sep 1, 2011 in |
The stem and root barks, leaves and seeds of Millettia pachycarpa Benth. are used for various medicinal purposes in Chinese and Mizo traditional practices. The plant extract reportedly showed potent vermicidal activity on cestodes. The ethanol extract of the root bark was tested against the poultry nematode, Heterakis gallinarum Schrank. In vitro treatment at 37±1°C revealed that a serial dose of the plant extract caused dose-dependent vermicidal effect on the worm (significant efficacy at P<0.05), except at the lowest dose (i.e. 5 mg/mL). A broad-spectrum drug albendazole also exhibited similar effect but with higher potency at all doses applied. The nematode treated with 80 mg/mL of the plant extract caused apparent destruction on the morphological structure, mostly of severe distortion in the cuticular organization throughout the body topography. Collapse of the lips and contraction of the body proper with prominent folding of the cuticle at the cephalic region were clearly discernible. At the posterior end were also extensive disintegration of the cuticle along with shrivelled cloacal mount and caudal...
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Posted by admin on Sep 1, 2011 in |
Recently much attention has been paid to the application of microemulsion as drug delivery system. Part of this interest appears as a consequence of their transparency, ease of preparation and long-term stability. These properties as well as their ability for incorporating drugs of different lipophilicity are some of the reasons why microemulsions have been thoroughly considered for pharmaceutical purpose. The aim of the present study is to improve the solubility of Terbinafine Hydrochloride, a slightly water-soluble antifungal drug by formulating a microemulsion made up of oil, surfactant and solubilizing agent/cosolvent. Tween 80, ajowan oil and peppermint oil were selected for preparing a microemulsion. Propylene glycol (PG) was used as a solubilizing agent. The effect of formulation variables on droplet size distribution was investigated. Droplet size was measured with Malvern Zetasizer instrument based on Photon Correlation Spectroscopy principle. The mean droplet diameter of microemulsions containing 1% w/w of terbinafine hydrochloride was below 100 nm and for the optimized formulation it was 8.1 nm. The optimized microemulsion was found to be...
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Posted by admin on Sep 1, 2011 in |
A novel, safe, accurate, sensitive and economic Spectrophotometric method was developed by application of mixed hydrotropy using solution containing 45% urea and 5% sodium citrate as hydrotropic solubilizing agent for the quantitative determination of poorly water-soluble budesonide from bulk and tablet dosage form. The solubility of budesonide increases more than 20 times in mixed hydrotropic solution as compared to solubility in distilled water, thus, a mixed hydrotropic solution containing 45% urea and 5% sodium citrate was employed to carry out spectrophotometric analysis precluding use of organic solvents. Budesonide obeyed Lambert Beer’s law in the concentration range of 5 to 30μg/ml (r2= 0.999) in mixed hydrotropic agent with mean recovery was found 98.75±0.63%. The percent concentration in marketed tablet formulation was found 98.56±1.070%. Parameters such as linearity, precision, accuracy, specificity and robustness were studied as reported in the International Conference on Harmonization guidelines. The relative standard deviations for three replicate measurements in five concentrations of samples were always less than 2%. So this method can successfully employ in the routine...
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