Posted by admin on Aug 1, 2011 in |
The methanolic bark extract of Mimusops elengi was investigated for its possible analgesic and neuropharmacological activities on mice at the doses of 100mg/kg, 200mg/kg and 400mg/kg body weight. For the evaluation of analgesic activity, tail immersion and acetic acid induced writhing tests were used. The neuropharmacological activity of the extract was screened using hole cross and open field tests to investigate the central nervous system depressant (CNS) activity. In tail immersion test, the extract produced a significant (p < 0.05-0.001) increase of latent time to flick tail compared to control in a dose dependent manner. In acetic acid-induced writhing test, the extract, at a dose of 400 mg/kg, showed a maximum of 65.48% inhibition (p <0.001) of writhing compared to the control while the reference drug Diclofenac-Na inhibited 76.36% of writhing. In CNS depressant activity tests, the extract significantly (p < 0.05-0.001) decreased motor activity and exploratory behavior of mice in hole cross and open field tests respectively. These results suggest that the extract possesses analgesic and CNS depressant...
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Posted by admin on Aug 1, 2011 in |
Moringa oleifera belongs to an onogeneric family of shrubs and tree, Moringaceae. In the Dravidian language there are many local names for Moringa oleifera but all are derived from the generic root “Morunga”. It has anticancer, anti-inflammatory activity and thyroid status regulator efficacies. An experiment was carried out to study the antibacterial activity of different solvent extracts of Moringa oleifera plant by agar well diffusion method against Bacillus subtilis, Escherichia coli, Klebsiella pnemoniae, Shigella dysentriae and Staphylococcus aureus that frequently cause enteric infections in humans. The benzene, methanol and aqueous extracts of Moringa oleifera leaves, bark, seed and flesh have shown strong antibacterial activity against all the organisms tested such as B. subtilis, E. coli, K. pneumoniae. S. dysentriae and S. aureus. The zone of inhibition ranged from 7-23mm. The plant Moringa oleifera can be used as a source of oral drugs to fight infections caused by susceptible...
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Posted by admin on Aug 1, 2011 in |
Rizatriptan is a selective 5-HT1B/1D agonist which is used in the treatment of migraine headaches. Zero order spectroscopic method has been developed for the determination of rizatriptan. Rizatriptan in its 0.1 N HCl solutions was determined at the wavelength ranges of 220–400 nm by the spectroscopic method. Rizatriptan showed an absorption peak at 226 nm. Linearity ranges were found as 1-5 µg/ml. for the zero order UV spectroscopic method. Limit of quantitation was determined as 0.0944 µg/ml whereas limit of detection was calculated as 0.0311 µg/ml for the same measurements, respectively. No interference was found from tablet excipients at the selected wavelengths and assay conditions. Developed method was found to be validated and showed good precision and reproducibility. Proposed method was successfully applied to the assay of rizatriptan in pure and tablet dosage forms and assessed as to be rapid, sensitive, accurate and relatively...
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Posted by admin on Jul 1, 2011 in |
Background: Type 2 Diabetes is a metabolic disorder, characterized by chronic hyperglycemia. It results from insulin resistance, a condition in which the body cells fail to use insulin properly. In Ayurveda Sesamum alatum L. (Pedaliaceae) has been used for the treatment of Diabetes. In this study, the antidiabetic activity of the Methanolic leaf extract of S. alatum was investigated, and the renal protective activity of the extract was also evaluated in diabetic rats. Materials & Methods: Antidiabetic activity of the Methanolic Leaf Extract of Sesamum alatum (MESA) was evaluated in the Streptozotocin (65mg/kg) induced Male albino rats. Blood was collected from the Retro orbital plexus of rats’ before and after the administration of MESA. Activity of 300 and 500 mg/kg doses of MESA were evaluated for a period of 30days. Urine samples were collected and analyzed for Albumin, BUN, Creatinine and Lipid parameters. In addition, Kidney MDA levels, Antioxidant enzymes (SOD, CAT) and Non-Enzymatic (GSH) levels were measured. Results: Dose-dependent reduction in blood glucose levels were observed in treated...
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Posted by admin on Jul 1, 2011 in |
A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of amlodipine and lisinopril in marketed formulation is developed. The determination was carried out on a Phenomenex C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of 0.02 M phosphate buffer solution: methanol (75:25v/v, pH 7.0). The flow rate was 1.0ml/min with detection at 212 nm. The retention time for amlodipine was 4.11 min and for lisiopril 7.29 min. Amlodipine and Lisinopril showed a linear response in the concentration range of 10-110 µg/ml. The correlation co-efficient (‘ r ‘ value) for amlodipine and lisinopril was 0.9991 and 0.9992, respectively. The results of analysis have been validated statistically and by recovery studies. The percentage recoveries obtained for amlodipine and lisinopril ranges from 100.04 to...
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