Posted by admin on Oct 1, 2011 in |
Five Indian Brands (coded as A,B,C,D,E) of 100 mg Nimesulide tablets were evaluated for various In vitro parameters, i.e. size and shape, uniformity of weight, hardness, friability, content, disintegration time and dissolution profile. All the products met the requirements of British Pharmacopoeia for tablet formulation. The hardness of all the brands was found to be in the range of 4.2-4.4 kg, while friability was less than 1 %. The disintegration time of all brands was found to be in the range of 2min 22 sec to 5min 29 sec. All brands comply the B.P weight variation test while brands A, B, C and D comply the B.P dissolution test except brand E. Formulation additives in the tablet, physical form of the drug used in the tablet and manufacturing process vary from manufacturer to manufacturer which is responsible for the variation in the observed dissolution...
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Posted by admin on Oct 1, 2011 in |
Objective: In the present work, the leaves and stems of Kalanchoe pinnata Linn. (Family: Crassulaceae) have been investigated for screening phytochemicals, cytotoxicity and antibacterial activities. Materials and methods: Brine shrimp lethality (BSL) bioassay was used as a pre-screening method for cytotoxic effect. Ethanolic extract of the plant was tested by using this method. The agar disc diffusion method was used for antimicrobial assay of the plant extract. Results: The crude extract produced the most significant cytotoxic activity against brine shrimp Artemia salina (LC50: 100μg/mL and LC90: 204.17μg/mL). The ethanolic extract of Kalanchoe pinnata Linn. showed significant antibacterial activity against gram positive (B. Subtilis, S. aureus) and gram negative (E. coli, P. aeruginosa, S. dysenteriae) bacteria with the zones of inhibition ranging from 6.0±0.35 to 8.2±0.22 mm. The phytochemical screening of the ethanolic extracts of Kalanchoe pinnata Linn. showed the presence of alkaloids, glycosides, steroids, gums, flavonoids, saponins, reducing sugars and tannins. Conclusion: The obtained results provide a support for the use of this plant in traditional medicine. The plant...
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Posted by admin on Oct 1, 2011 in |
In the present study a series of chalcone- semicarbazones was synthesized and evaluated for their antibacterial activity by paper disk diffusion method. Based on the results of an antibacterial study, compound 28 was the most active compound against gram negative bacteria. Synthesized compounds were inactive against gram positive bacteria. It was found that chloro- substitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone exhibited better antibacterial activity against gram negative bacteria but lengthening of carbon chain does not favor antimicrobial...
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Posted by admin on Oct 1, 2011 in |
Three rapid, simple, precise and sensitive visible spectrophotometric methods (A-C) have been developed for the determination of pipazethate hydrochloride (PZ-HCl) and Chlorphenoxamine hydrochloride (CPA-HCl) in pure and Tablet Dosage Forms. Both methods (A-C) involves the formation of intense yellow ion-association complex between drug(s) and either of picric acid (PA) or phenol red (PR) or chlorophenol red (CPR) reagents followed by extraction with methylene chloride. The ion-associates exhibit absorption maxima at 359, 393 and 405 nm for PZ-HCl and at 357, 388 and 400 nm for CPA-HCl with PA, PR and CPR, respectively. The calibration curves resulting from the measurements of absorbance–concentration relations (at the optimum reaction conditions) of the extracted ion-association complexes are linear over the concentration range 3.05-43.60, 8.72-104.64 and 3.27-49.05 μg/mL for PZ-HCl and 3.40-47.64, 8.51-88.48 and 3.40-40.84 μg/mL for CPA-HCl with PA, PR and CPR, respectively. The molar absorptivities and Sandell’s sensitivities of the reaction products were calculated. In methods (A-C) the slope, intercept, correlation coefficient, relative standard deviation (RSD), detection and quantitation limits were also...
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Posted by admin on Oct 1, 2011 in |
Anti-ulcer properties of the alkaloids isolated from the fruit of Cucumis metuliferous was investigated in mice. Ethanol-induced gastric lesion was used to assess the anti-ulcer activity. In this study, there was a significant (p<0.05) decrease in haemorrhages and ulcerations of the gastric mucosa at 500 and 1000 mg/kg of the alkaloid compared with control. The activity of the extract is comparable to that of the standard control group administered ranitidine (1 mg/kg). The alkaloids of C. metuliferus showed a demonstrable potential as an anti-ulcer agent that could be used for the treatment of peptic ulcer...
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