Posted by admin on Jun 1, 2011 in |
The purpose of this research was to develop fast dissolving tablets of olanzapine and to optimize the processing variables. Tablets containing olanzapine, camphor, crosscarmellose, and directly compressible lactose were prepared by direct compression technique. The tablets were compressed and later exposed to vacuum. Sublimation of camphor from tablets resulted in superior fast dissolving tablets. The tablets were evaluated for percentage friability, wetting time, and disintegration time. In this investigation, a 22 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of camphor and crosscarmellose. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of camphor and a higher percentage of crosscarmellose. The systematic formulation approach helped in understanding the effect of formulation processing...
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Posted by admin on Jun 1, 2011 in |
In the present study crude methanolic extract of Stephania japonica leaf was investigated for possible antioxidant, analgesic and cytotoxic activity. The extract showed antioxidant activity in DPPH radical scavenging activity, nitric oxide scavenging activity and reducing power assays. In both DPPH radical and NO scavenging assay, the extract exhibited moderate antioxidant activity and the IC50 values in DPPH radical scavenging and NO scavenging assays were found to be 105.55 ± 1.06 μg/ml and 129.12 ± 0.15 μg/ml, respectively while the IC50 values of ascorbic acid were 12.30 ± 0.11 μg/ml and 18.64 ± 0.22 μg/ml, respectively. Reducing power activity of the extract increased in a dose dependent manner. Analgesic activity of the crude extract was evaluated using acetic acid-induced writhing model of pain in mice. The crude extract at 200 mg/kg and 400 mg/kg b.w. doses displayed significant (p < 0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 75.89 % reduction at 400 mg/kg b.w. which is comparable to the standard, diclofenac sodium...
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Posted by admin on Jun 1, 2011 in |
An HPTLC method for estimation of Fluoxetine in its capsule formulation has been developed. It employs aluminium backed silica gel 60 F254 TLC plates, (20 cm × 10 cm, layer thickness 0.2 mm) prewashed with methanol and mobile phase comprising of toluene: 2-propanol: ammonia 2:2:0.4 (v/v/v). The developing solvent was run upto 80 mm in Camag chamber previously saturated with 10.0 mL of solvent mixture for 30 min. Densitometric scanning was then performed with Camag TLC scanner-3 equipped with winCATS software Version 1.3.0 at λmax 227 nm. The Rf value was found to be 0.74. The recovery of Fluoxetine was found to be 99.90% ± 1.68. The limit of detection and limit of quantitation were found to be 43.55 ng/spot and 131.99 ng/spot. The % RSD of intra-day variation and inter day variation were 0.54 and 0.41...
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Posted by admin on Jun 1, 2011 in |
The present study was undertaken to evaluate the locomotor effect of chloroform extract of Semecarpus anacardium (Linn.) (CHSA) by using photoactometer. Its anticonvulsant property was tested against maximal electroshock (MES)-induced convulsion (MESIC), pentalenetetrazol (PTZ)-induced convulsion (PTZIC), strychnine-induced convulsion (SIC), picrotoxin-induced convulsion (PIC), isoniazid (INH)-induced convulsion (IIC) and 4-amino pyridine (4-AP)-induced convulsion (4-APIC) in mice. The gamma-amino butyric acid (GABA) level was estimated by spectroscopic method. Significant reduction in locomotor scores were recorded with a diazepam (5 mg/kg) but not with CHSA (100, 200 & 400 mg/kg). In MESIC a phenytoin (25 mg/kg) was possessed anticonvulsant activity by decreased duration of tonic extension phase of the animals but not with CHSA. In PTZIC, SIC PIC, IIC and 4-APMIC models, a diazepam exhibited anticonvulsant effect, the CHSA was ineffective among all those paradigms. Increased GABA level in the mice serum was observed with a gabapentin (20 mg/kg) treated group, in CHSA such effect was not observed. Hence it concluded that Semecarpus anacardium (Linn.) not possesses sedative and anticonvulsant...
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Posted by admin on Jun 1, 2011 in |
The root of Heliotropium indicum is reported to have good medicinal values in traditional system of medicines. Commonly called as Indian Turnsole, is a herb with slightly woody at base. It is distributed in the tropical and temperate regions of the world and found throughout India The present study deals with phytochemical investigations of Heliotropium indicum root including determination of loss on drying(3.8%), Ash values{total ash(6.3%), acid insoluble ash(3.5%), water soluble ash(3.2), sulphated ash(6%)} and extractive values{water soluble extractive(21%), alcohol soluble extractive(2%), benzene soluble extractive(1.5%), Petroleum Ether soluble Extractive(2.1%)}. The preliminary phytochemical screening of powdered drug was also carried out. The qualitative chemical examinations revealed the presence of various phytoconstituents like alkaloids, carbohydrates, phytosterols, tannins and saponin in the root extracts through the chromatographic separation technique i.e. TLC . These observations therefore support the use of Heliotropium indicum in herbal cure remedies. Alkaloids which are one of the largest groups of phytochemicals in plants have amazing effects on humans and this has led to the development of powerful pain...
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