Posted by admin on Apr 1, 2011 in |
The effect of different percentages of a hydrophilic polymer and impact of granulation technique on the release profile of gliclazide from matrix system was investigated. Matrix tablets of Gliclazide were prepared by both direct compression and wet granulation process using METHOCEL K15M CR. Release kinetics of Gliclazide matrix tablets were determined using USP paddle method at Phosphate buffer (pH 7.4) and conducting for 10 hours. Statistically significant differences were found among the drug release profile from different polymeric concentration and granulation process. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer model. It’s found that at lower concentration of polymer (15%) most of the formulation tends to Higuchi release kinetics and at higher concentration (30%) best fit with Zero order release kinetics. Higher polymeric content (30%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (15%) the rate of drug release was elevated. In this study effect of granulation process on drug...
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Posted by admin on Apr 1, 2011 in |
A number of aldehydes were reacted with acetyl acetone or ethyl acetoacetate and urea under Biginelli reaction conditions to give the corresponding 5-acyl-4-(substituted-aryl)-6-methyl-3,4-dihydropyrimidin-2-one. The 5-acetyl-derivatives were converted into pyrimido-oxazoles, pyrimido-pyrazoles, and chalcones. Some Mannich bases were also synthesized. Some selected compounds were tested for their antimicrobial...
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Posted by admin on Apr 1, 2011 in |
Many chemo prophylactic approaches to manage or prevent opportunistic infections using many drugs have been reported. Based on the reported cases of chemo prophylactic approaches to manage opportunistic infections, the effect of Cotrimoxazole on HIV patients was studied. Seventy two patients with CD4+ cell counts ≤ 350cells/µl were recruited for the study. Each patient received cotrimoxazole two single strength tablets (2 x 480mg) three times a week. The patients were followed for a period of six months during which time data was collected at month 1, month 3 and month 6. The results showed that dermatological, gastrointestinal and respiratory as well as other bacterial related infections were considerably reduced in these patients during the six month period of the study. Being a drug that is cheap, readily available and not requiring any special storage and handling conditions, cotrimoxazole could be considered as a good prophylactic agent in the management of HIV/AIDS disease in resource limited settings such as...
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Posted by admin on Apr 1, 2011 in |
The seeds and leaves of Ficus racemosa have shown considerable antioxidant and cytotoxicity properties while their antibacterial activities were found low. The extracts were found to have different levels of antioxidant and cytotoxicity properties in different concentration. For antioxidant activity, here we used free radial scavenging activity of plant extracts against stable DPPH (1, 1-diphenyl 2-picrylhydrazyl) which was determined spectrophotometrically by the method described in Brand William et al., (1995). Methanolic extracts of these plants were used. As we know that ascorbic acid is a perfect antioxidant, that’s why it was used as a standard reference. The absorbance was taken at 517nm by UV spectrophotometer. The IC50 (Inhibitory Concentration) value of standard was 8.287µg/ml. The IC50 value of Ficus racemosa seeds and leaves were 3.893µg/ml and 14.5µg/ml respectively. For Cytotoxicity, brine shrimp lethality bioassay was used. We used Vincristine sulfate as a standard reference. The LC50 value of standard was 0.057µg/ml. The LC50 (Lethal Concentration) value of the seeds and leaves were 0.56µg/ml and 0.467µg/ml respectively. The plant has...
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Posted by admin on Apr 1, 2011 in |
Hepatitis is major health problem in human being due to various chemical including therapeutic agent and environmental toxin and this can leads to illness like jaundice, which sometime may lead to even death. Ipomoea digitata Linn. is used in ayurvedic formulation for various disease conditions and commonly known as “Vidarikanda”. The present study deals with hepatoprotective activity hydroethanolic extract of tuberous root of Ipomoea digitata Linn. against CCl4 (i.p) induced liver damaged in female Wister rat. The drug was extracted and preliminary phytochemical screening of extract was done then extract was subjected to toxicity study. The hydroethanolic extract of tuberous root of Ipomoea digitata Linn. was administered orally at the dose of 250mg/kg and 500mg/kg .These shows significant protective effect on liver evidenced by lowering serum level of ALT, AST, ALKP, TB, DB, and Serum Triglyceride and also by histopathological study. All result obtain result are compared with standard (Silymarin) and control group. Thus it concludes that hydroethanolic extract of Ipomoea digitata Linn. shows significant hepatoprotective activity prevents chemically...
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