Posted by admin on Feb 28, 2025 in |
This study focuses on developing and characterizing metformin microspheres using spray drying with hydroxypropyl methylcellulose (HPMC) as a polymer, aiming to enhance gastrointestinal drug delivery, reduce gastric irritation, and lower dosage requirements for type 2 diabetes management. Metformin hydrochloride and HPMC concentrations are varied to generate microspheres with1 to1000µm diameter. These biodegradable polymers were selected because of their efficacy and compatibility with drugs. The thermal analysis and compatibility of the excipients used in microsphere tablet compression are assessed using differential scanning calorimetry and Fourier transform infrared spectroscopy. In-vitro drug release behaviour is evaluated over an 8-hour period using a Copley dissolution tester in 0.1 N HCl at 37 ± 0.5°C, with drug release monitored by UV spectroscopy at 228 nm. Results show that metformin release from microspheres is sustained for the first 6 hours, with a decrease noted at the 8-hour mark. The Higuchi model suggested diffusion-controlled release, while the Korsmeyer-Peppas model indicated non-Fickian diffusion. Some other drug release kinetic models, such as zero-order and first-order kinetic models are...
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Posted by admin on Feb 28, 2025 in |
Background: Diabetes is one of the leading non communicable disease-causing various health complications like Cerebrovascular accidents, micro and macrovascular complications. In Indian population, very few comparison studies have been conducted to evaluate the glucose lowering effect of omega 3 fatty acid between diabetic and non- diabetic dyslipidemic patients. Hence the present study was planned to compare the efficacy of omega 3 fatty acid among diabetic and non-diabetic dyslipemic individuals. Materials And Methods: This study is a comparative, randomized, open-label, prospective interventional study which compared the efficacy of omega 3 fatty acids as add on therapy among diabetic and non-diabetic Dyslipidemic patients.50 Patients of 25 each of diabetic dyslipidemia and non-diabetic dyslipidemia attending the out-patient department of Internal Medicine, Rajiv Gandhi Government General Hospital, Chennai were given 1 gram of omega 3 fatty acid- fish oil capsule per day once daily to take orally for 8 weeks and monitored for random blood glucose at baseline (0 weeks), after 4 weeks and after 8 weeks of treatment. Results: At 4 weeks...
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Posted by admin on Feb 28, 2025 in |
Objectives: Transitioning from a family-centred clinic to a patient-centred clinic is an inevitable and fragile process through which patients and caregivers have to go through. This study aimed to identify transition issues and assess the role of pharmacists during this phase. Method: A mixed-method approach combining qualitative and quantitative analysis was used to identify factors that may contribute to uncontrolled diabetes during the transition period. Due to the challenges posed by the COVID-19 pandemic, three online questionnaires were developed, reviewed, and distributed via social media to patients, caregivers, and healthcare professionals. Key Findings: Concerns were raised about being under the care of a new doctor and not being provided enough support and care during the transition. Participants noticed a shift towards self-management as they moved between clinics. Furthermore, there was strong support for the involvement of pharmacists in the transition process, with participants agreeing that pharmacists could help reduce medication errors. Conclusion: A well-structured transition plan can ease the shift from paediatric to adult care. A multidisciplinary approach, involving...
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Posted by admin on Feb 28, 2025 in |
An ayurvedic nutritional tonic, i.e., Dashmularishta, is made up of ten different plants that support gut health and restore appetite by relieving indigestion, bloating, etc. U. picta is one of the important medicinal plant used in this formulation. Due to ever increasing demand U. picta is now in the status of endangered. As a result, many of its similar species are being used as its adulterant in the formulation. A comparative study has been performed on U. picta and its adulterant species (D. gangaticum, D. puchellum, D. velutinum, D. longipes, and L. reticulate) for their effectiveness against multidrug-resistant bacteria. The plant extracts from these plants were screened against ten different clinical isolates of multidrug-resistant bacteria. U. picta, D. gangaticum, and D. puchellum exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. However, U. picta presented minimum inhibitory concentrations (MICs) of 25 mg/ml and 12.5 mg/ml against Staphylococcus aureus and Escherichia coli, respectively. In contrast, D. gangaticum presented MICs of 12.5 mg/ml and 50 mg/ml against Staphylococcus aureus and Escherichia...
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Posted by admin on Feb 28, 2025 in |
Background: Depression is a major public health disorder, with antidepressants like Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) improving outcomes for Major Depressive Disorder (MDD) patients. However, determining which category is superior remains unclear. This study aimed to compare the efficacy and safety profile of Escitalopram (SSRI) versus Venlafaxine/Desvenlafaxine (SNRIs) in patients of depression. Material and Methods: An observational cross-sectional study was conducted at Outpatient Department (OPD) of Psychiatry; in 120 eligible MDD patients, already taking tablet escitalopram (10-20 mg/day) or venlafaxine (75 – 375 mg/day)/desvenlafaxine (25-100 mg/day) at least for 1 month duration. Therapeutic Efficacy was assessed by HAM-D (Hamilton rating scale for Depression) and CGI (Clinical Global Impressions) Scale. Safety profile was evaluated with the help of ASEC (Anti-Depressant Side Effect Checklist) by assessing the adverse effects experienced by patients. Independent t-test and chi square test were used to analyse quantitative and qualitative variables respectively. Results: Mean (±SD) scores of HAM-D and CGI scales in escitalopram group were significantly higher than venlafaxine/...
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