Posted by admin on Dec 31, 2025 in |
Navamani Chenduram (NC) is one of the metallic preparations mentioned in the classical Siddha literature “Sikitcha Rathina Deepam” which is indicated mainly to treat female reproductive diseases like amenorrhea, ovarian tumor and ascites. Preparing the Trial drug in accordance with the standard operating procedure and put through a number of studies to ensure its safety, effectiveness, purity, and quality. WHO has highlighted the necessity of employing contemporary methods to guarantee quality control of Indian medicines. The aim of the study was to standardize the NC through Sophisticated instrumentation techniques like Inductively Coupled Plasma – Optical Emission Spectroscopy (ICP-OES), Fourier Transform Infra-Red (FTIR), Scanned Electron Microscopy with Energy Dispersive X-Ray Analysis (SEM EDAX) and X-ray Diffraction (XRD) for the detection of Functional group, Chemical, Elemental analysis, Particle size, Heavy metals analysis and Minerals present in NC. Also identified the drug substance forms and determine its molecular structure. The results showed that under ICP OES Heavy metals like Aluminum, Arsenic, Copper, Magnesium, and Mercury were found below the detection level. The...
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Posted by admin on Dec 31, 2025 in |
Background: Nephrotic syndrome is a kidney disorder characterized by heavy proteinuria, hypoalbuminemia, and often hyperlipidemia. Thyroid hormones play a crucial role in growth, development, and overall metabolic function. In the circulatory system, these hormones are primarily bound to specific proteins for proper distribution and regulation throughout the body. The substantial loss of these binding proteins innephrotic syndrome may lead to a reduction in circulatory levels of thyroid hormones, potentially resulting in a hypothyroid state. We conducted this study to find out the prevalence of hypothyroidism in pediatrics patients in Barpeta region of Assam, India. Methods: An observational, cross-sectional study of 67 patients was conducted, admitted in the Department of Pediatrics, diagnosed with nephrotic syndrome fulfilling the inclusion criteria were enrolled. Consecutive sampling method was used. Statistical analysis was performed using SPSS software (version 21.0). Categorical data was expressed as frequency and percentage, while continuous data was expressed as mean and standard deviation. Results: Hypothyroidism was present in 32.8% of cases and no statistically significant difference in hypothyroidism prevalence was...
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Posted by admin on Dec 31, 2025 in |
Background: Human Metapneumovirus (HMPV) remains a significant respiratory pathogen without specific antiviral therapy. Traditional Ayurvedic formulations like Dabur Chyawanprash, composed of numerous medicinal plants, may harbor bioactive compounds with antiviral potential. This study explores phytochemicals from Chyawanprash alongside FDA approved drugs; Ribavirin, Penicillin V and Ibuprofen for their suitability as antiHMPV agents using in-silico approaches. Materials and Methods: A total of 41 medicinal plants were screened, and their phytochemicals evaluated using SwissADME for pharmacokinetic profiling and ProTox-II for toxicity prediction. Compounds with favorable ADMET properties were docked against five essential HMPV targets: polymerase phosphoprotein complex (6U5O), prefusion closed trimer (8W3Q), M2-1 tetramer (4CSA), prefusion trimer (8VT3), and N-P complex (5FVD). Docking was performed using AutoDock Vina interphase of PyRx, and molecular interactions were analyzed via Discovery Studio. Results: Seven phytochemicals met ADMET and drug likeness criteria, with propanoic acid and 1-butanol demonstrating optimal GI absorption, BBB permeability, and non-toxic profiles. Among targets, Penicillin V and Ribavirin exhibited the strongest binding, particularly with the N-P complex (-7.7 and -7.2 kcal/mol)....
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Posted by admin on Dec 31, 2025 in |
Background: The internet has become an integral part of daily life, with its usage growing exponentially. However, excessive use may lead to addictive behaviors and mental health challenges. Medical undergraduates are particularly susceptible due to their extensive engagement with online platforms. Aim: To estimate the prevalence and pattern of internet addiction among medical undergraduates and explore perceived reasons for excessive internet use. Methods: A convergent parallel mixed-methods study was conducted among 110 medical undergraduates across all academic phases between March and August 2024. Young’s Internet Addiction Test (IAT) was used to assess addiction levels, along with a structured questionnaire to collect related information. Qualitative open-ended question was included to gain deeper insights into students’ experiences with internet use. Quantitative data was analyzed by using proportions and chi square test. Thematic analysis was performed on transcribed qualitative responses, and a word cloud was generated to depict frequently occurring terms. Results: Among participants, 70.91% had mild addiction or were average users, 20.91% had moderate addiction and 8.18% were not addicted. Thematic...
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Posted by admin on Dec 31, 2025 in |
Introduction: Paratyphoid fever is an enteric infection caused primarily by Salmonella enterica serovars Paratyphi A, Paratyphi B and Paratyphi C. It accounts roughly for 20-30% of total enteric fever cases globally, and this proportion is rising, particularly where typhoid vaccination efforts are underway. The current study was planned to determine the seroprevalence of paratyphoid fever and the epidemiological details of the affected cases in our region. Material and Methods: The study was conducted for a period of eighteen months from January 2023 to July 2024 on serum samples from patients suspected of enteric fever were tested with Widal test. The results were interpreted based on regional baseline antibody titers and analyzed. Results: Out of 3310 samples, 1102 tested positive by Widal test. Forty five cases showed agglutinins for Paratyphi A or Paratyphi B or both. Twenty six were female (57.8%) and highest burden of infection was observed in age group less than 15 years (46.7%) followed by 16-45 years (42.2%) with a mean age of 18.9 years. Conclusion: Epidemiology...
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