This study deals with the synthesis and evaluation of antimicrobial activity of some novel Thiophene acrylate compounds. Totally fourteen compounds have been synthesized with different heterocyclic moieties on the Thiophene acrylate in order to study their influence on the antimicrobial activity. These compounds demonstrated potent to weak antibacterial activity against Gram-positive...
Read MoreThe ethanolic extract of whole plant of Coriandrum sativum Linn., family: Umbelliferae, was assessed for its possible analgesic, antidiarrhoeal, antimicrobial and cytotoxic activity. Preliminary phytochemical screening of the ethanolic extract revealed the presence of alkaloids, tannins, glycosides, and gums. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibited significant (p<0.001 & p<0.001) inhibition of writhing reflex 62.12% and 72.73% respectively compared to standard diclofenac sodium. The extract showed a significant (P<0.01 and P<0.001) antidiarrhoeal activity against castor oil induce diarrhea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 250 mg/kg and 500 mg/kg body weight. The ethanolic extract showed moderate antibacterial activity against both gram-positive and gram-negative bacteria. In the brine shrimp lethality test, the extract showed cytotoxicity significantly with LC50 40 μg/ml which was comparable to that of standard drug Chloramphenicol (LC50 20 μg/ml). All the results tend to justify the traditional uses of the plant and require further investigation...
Read MoreA series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C...
Read MoreThe various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity in rats. Activities of liver marker enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins at an oral dose of ethanol extract of Balanites aegyptiaca (100 and 200mg/kg) showed a significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Balanites aegyptiaca exhibited a significant effect showing increasing levels of SOD, CAT, GPX and GRD by reducing malondialdehyde (MDA) levels....
Read MoreThe electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of tinidazole was found to be irreversible so kinetic parameters (Ko fh, αn) are evaluated using Meites-Israel and Gaur-Bhargava’s methods. Thermodynamic parameters such as ∆Hp≠, ∆Hv≠, ∆G≠ and ∆S≠ are also evaluated....
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