Posted by admin on Feb 1, 2011 in |
The purpose of this research was to improve the granulation efficiency and the final granule characteristics for the any kind of the material that is to be granulated via FBG process. The fluid bed granulation process is an influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature etc. These process variables largely affect the granulation efficiency and the final granule characteristics. The effect of starting materials on granule properties was previously studied. The aqueous solution of 5% PVP K-30 was used as a binder and sprayed on lactose monohydrate bed. A full factorial design was applied to optimized the granulation process variables like inlet air temperature, spray rate and batch size and other granule properties, namely the Carr’s index, Hausner index, the angle of repose and the moisture content, were evaluated at the optimal operation conditions. Granules prepared by this technology have good flow property, good compressibility; and good flow ability with a proper adjustment of process variables. So FBG technique has its own...
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Posted by admin on Feb 1, 2011 in |
Casein microparticles cross linked with glutaraldehyde were prepared by steric stabilization process and the controlled release of drug from the particles were evaluated in-vitro. Casein is a natural biopolymer present abundantly in milk is utilized because of its biocompatibility through oral route. Methotrexate loaded Casein microparticles of size 0.5 to 5 µm were prepared. The release of methotrexate from the casein microparticles were evaluated in simulated gastric and intestinal fluids in-vitro. The coating of the particles with Eudragit L 100 made them as pH sensitive and therefore we found a significant release in the intestinal pH. The particles were resistant to proteolytic activity which can increase the durability of the particles in the intestine. This study demonstrates that the casein microparticles can be made pH sensitive and it can be successfully used as a targeted delivery system....
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Posted by admin on Feb 1, 2011 in |
The present work describes new spectrophotometeric methods for the assay of four drugs namely Meropenem (MPN), Cefditoren Pivoxil (CTP), Mesalamine (MSL) and Cefdinir (CDN) in both pure form and Pharmaceutical formulations. All methods involve the oxidative coupling reaction of MPN, CTP, MSL and CDN with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in presence of Fe(III) in an acidic medium to form colored products with absorption maxima at 620, 630, 500 and 620 nm respectively. Beer’s law was obeyed in the ranges of 5-25, 5-40, 5-25 and 2-12 µg/ml for MPN-MBTH, CTP-MBTH, MSL-MBTH and CDN-MBTH respectively. Statistical treatment of the experimental results indicates that the methods are precise and accurate. The proposed methods have been applied to the determination of the active components in commercial formulations with no interference from excipients. A comparative study between the suggested procedures and reference procedure for these compounds in the commercial formulations showed no significant difference between two...
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Posted by admin on Feb 1, 2011 in |
Plants have traditionally provided a source of hope for novel drug compounds, as plant herbal mixtures have made large contributions to human health and well-being. We report in this work for the first time, the potent antibacterial activity of Punica granatum and its wild form daru. Ethanol, petroleum ether and distilled water extract of fruit’s white membrane were screened for in vitro activity against four dental bacteria- Streptococcus sp., Lactobacillus sp., Staphylococcus sp. and Proteus sp. This plant was selected due to its traditional use for the treatment of oral infections. Among three tested extracts ethanol extract was the most effective against all the four dental...
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Posted by admin on Feb 1, 2011 in |
The purpose of the study was to determine the in vitro as well in vivo efficiencies of 1% carbopol hydrogel different preparations containing the meloxicam, a cyclooxygenase-2 inhibitor anti-inflammatory drug with b-cyclodextrin. The release of plain drug was then compared with release of from trans dermal gel containing physical mixture of drug and b-cyclodextrin, inclusion complex of drug and b-cyclodextrin obtained by kneading method and in situ complex of drug and b-cyclodextrin obtained by reacting the drug and b-cyclodextrin within the gel. All solid inclusion complex abstained were then characterized by x-ray diffractrometry, infrared spectroscopy, differential scanning colorimetry and scanning electron microscopy, where as the in situ complex formation was evidenced only by release and permeation studies. Although many other derivative of cyclodextrins such as hydroxy propyl-b-cyclodextrin and methylated-b-cyclodextrin are better skin permeating enhancers but in this study b-cyclodextrin was employed because of ease of availability and low cost. Solid inclusion complex was prepared by kneading method. Gel formulations were prepared by incorporating pure drug, physical mixture, inclusion complex...
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