Posted by admin on Jun 1, 2011 in |
The present study was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of flower buds of Peltophorum pterocarpum on alloxen and glucose indueced diabetic mouse model. The extract was given intraperitonially at a dose of 200 mg/kg body weight and the hypoglycemic effects compared with metformin, a standard drug. The extract reduced blood glucose level in alloxan-induced diabetic mice by 60.40%, and 65.48% reduced by metformin at 12 hours in 24 hours treatment period. Preliminary phytochemical screening of the extract revealed the presence of different types of compounds including flavonoids and steroids. Our results suggest that Peltophorum pterocarpum has potential antidiabetic activity and may provide new molecules for the treatment of...
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Posted by admin on Jun 1, 2011 in |
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method against Gram-positive bacterial strains (Bacillus subtillis, Staphylococcus aureus) Gram-negative bacterial strains (Pseudomonas aerugenosa, Kleibsella pneumonia) and fungal strains (Aspergillus niger, Candida albicans). The analogues 1b, 1h and 1i showed promising antimicrobial activity against gram-negative Kleibsella pneumonia; where as analogues 1b, 1e, 1g and 1h showed promising antifungal activity against Candida...
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Posted by admin on Jun 1, 2011 in |
The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl- Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl- Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer...
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Posted by admin on Jun 1, 2011 in |
In Traditional Ayurvedic system of treatment Tragia involucrata Linn. is intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, aqueous ethanolic extract of Tragia involucrata (AEETI) was administered orally for 28 days at a dose of 250 and 500 mg/kg body weight to Streptozotocin- Nicotinamide induced Wistar rats. All the animals were sacrificed on the 29th day and the levels of LPO, SOD, CAT, GPx and GSH in kidney and liver of control and experimental rats were studied. The AEETI exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with AEETI lowers Streptozotocin induced LPO and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative...
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Posted by admin on Jun 1, 2011 in |
Digera muricata (L.) Mart (Amaranthaceae) commonly known as Cancali soppu widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Digera muricata(MEDM) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in alloxan induced diabetic rats. MEDM (100, 200 mg/kg) and Glibenclamide (3mg/kg) were administered orally in alloxan (140 mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEDM no mortality upto 2000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, lipid profiles, HbA1c, plasma insulin, and ALP were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract .These results suggest that MEDM (200mg/kg) showed antihyperglycemic activity in alloxan induced diabetic...
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