Posted by admin on Aug 15, 2010 in |
Purpose of Study: In the present study, an attempt was made to design and evaluate buccoadhesive bilayer tablets of granisetron hydrochloride (an anti-emetic drug), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Method: Bilayer buccal tablets containing the drug were prepared by direct compression method using combination of polymers (such as hydroxypropyl methylcellulose 15 cps, sodium carboxymethyl cellulose and Carbopol 934p.) and ethyl cellulose as backing layer. The designed tablets were evaluated for various physical and biological parameters, drug content uniformity, in-vitro drug release, short-term stability, drug- excipients interactions (FTIR). Results: The formulation HF1 with the drug matrix layer composition- hydroxypropyl methylcellulose 15 cps (47% w/w), Carbopol 934p (3%w/w), and mannitol (channeling agent, 45% w/w) was found to be promising. This optimized formulation exhibited an in vitro drug release of 94% in 8 h along with satisfactory bioadhesion strength (4.3 gm). Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro...
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Posted by admin on Aug 15, 2010 in |
There is increasing evidence to support the involvement of free radical reactions in several human diseases. n recent years, it has become increasingly apparent that in man, free radicals play a role in a variety of normal regulatory systems, the de-regulation of which may play an important role in inflammation. Active oxygen species and other free radicals have long been known to be mutagenic. Further, these agents have more recently emerged as mediators of the other phenotypic and genotypic changes that lead from mutations to neoplasia. Therefore, free radicals may contribute widely to cancer development in humans. The antioxidant activities of the plant extract and pure compounds were assessed on the basis of radical scavenging effect of the stable DPPH free radical. Generally plants containing flavonoids having strong antioxidant properties. The six extracts Ricinus communis stem and two standards tested for antioxidant activity using DPPH method, the benzene and 50% methanol successive extracts showed the maximum antioxidant activity with IC50 values of 36.19 ± 2.332 mg/ml and 34.40 ±...
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Posted by admin on Aug 15, 2010 in |
Felodipine, a calcium channel blocker, is used for hypertension and angina pectoris. Felodipine fast- disintegrating tablets (FDT) have been prepared by direct compression method. Effect of superdisintegrants (like crosspovidone, croscarmellose sodium and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release and stability parameter has been studied. Disintegrating time and dissolution parameter (t50% and t90%) decreased with increases in the level of croscarmellose sodium and crosspovidone whereas disintegration time and dissolution parameter increased with increase in the level of more than 5% sodium starch glycolate. The formulation did not show any change in disintegration time, wetting time and drug content after stability period. It was concluded that fast disintegrating Felodipine tablets can be prepared by direct compression using...
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Posted by admin on Aug 15, 2010 in |
The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness and in–vitro dissolution study. All tablets but one exhibited gradual and near completion sustained release for Diclofenac Potassium and 98.72 % released at the of 12 hours. The results of dissolution studies indicating that formulation D5 (drug to polymer 1:1.40) the most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetic of the drug was observed on increasing polymer ratio. Applying the exponential equation, all the tablets (except D5) showed diffusion dominated drug release. The mechanism of drug release from D5 was diffusion coupled with...
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Posted by admin on Aug 15, 2010 in |
Chlorthalidone is a phthalamide derivative of benzene sulphonamide and is designated as 2- chloro- 5- (1- hydroxy- 3- oxo- 1- isoindolinyl) benzene sulphanilamide. It is white to yellowish crystalline powder. It is practically insoluble in water, slightly soluble in alcohol. In the present study fast disintegrating tablets of chlorthalidone were prepared by adopting vacuum drying technique to study the effect of different subliming agents with various concentrations on disintegrating time. The powder blend was examined for the pre-compressional parameters. Formulations were evaluated for pre-compressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Tablets were subjected to post-compressional analysis for the parameters such as hardness, friability, in-vitro disintegration time, wetting time and dissolution test. Drug compatibility with excipients was checked by FTIR and DSC studies. Stability studies were carried out as per ICH guidelines for three months. The results obtained showed that quantity of camphor, ammonium bicarbonate, menthol, and urea significantly affect the response variables (P> 0.05). The results revealed that tablets prepared by the vacuum drying...
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