Posted by admin on Jan 1, 2011 in |
Meloxicam (MEL) is an oxicam derivative and a member of the enolic acid group of non-steroidal anti-inflammatory drugs (NSAIDs). Most of the reported methods for HPLC analysis of Meloxicam are cumbersome, time-consuming and expensive. Reverse phase chromatographic analysis was performed on a C18 Hi Q Sil column with methanol–water- orthophosphoric acid (80:19.9:0.1 % v/v) at a flow rate of 1ml/min and detection wavelength of 360 nm. System suitability tests essential for the assurance of quality performance of the method were performed. The method was validated for accuracy, precision, reproducibility, specificity and robustness, limit of detection (LOD) and limit of quantification (LOQ). A single sharp peak was obtained for MEL at Rt of 4.38 ± 0.02 min. The polynomial regression data for the calibration plots exhibited linear relationship (r = 0.999) over a concentration range of 4–20µg/ml and the linear regression equation was y = 43754x – 2094. Accuracy ranged from 99.33 to 100.45% and the % coefficient of variation (CV) for both intra-day and inter-day precision was less than...
Read More
Posted by admin on Jan 1, 2011 in |
Lornoxicam (chlortenoxicam) is a non steroidal anti- inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parental dosage formulation. Lornoxicam is a Yellow or slightly yellow powder. It is slightly soluble in water, soluble in hydrochloric acid, slightly soluble in methanol. A simple spectrophotometric method was developed for the determination of lornoxicam in pharmaceutical tablet dosage form. Lornoxicam exhibiting λ max at 380 nm in mobile phase (phosphate buffer: methanol) in ratio of 50:50 and obeyed linearity in the concentration range of 1-20mcg. The proposed method was statistically...
Read More
Posted by admin on Jan 1, 2011 in |
In the present study, eight organic solvents and aqueous extracts of Canavalia mollis leaves were screened for their phytochemical composition, anti bacterial and free radical scavenging activities. Among the different extracts tested, ethanol, methanol and acetone extracts showed significant antimicrobial and radical scavenging activities. The most susceptible microorganisms were found to be Escherichia coli, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis. Preliminary phytochemical analysis of the leaf extracts revealed that the antibacterial and the radical scavenging activities are mainly due to the presence of the phenolic compounds especially alkaloids. The results obtained suggest that C. mollis could be exploited in the infections management of various...
Read More
Posted by admin on Jan 1, 2011 in |
Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-induced hind paw oedema and formaldehyde-induced hind paw oedema in rats. The ethanol soluble fraction was found to be the most potent among them which shows good anti-inflammatory response with reference to the standard drug...
Read More
Posted by admin on Jan 1, 2011 in |
Bambuterol HCl is a potent anti-asthmatic agent, act by stimulation through beta-adrenergic receptors of intracellular adenylcyclase. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. In the present study, an attempt has been made to prepare fast dissolving tablets of Bambuterol HCl in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carmellose sodium, Pregelatinized starch by direct compression method. The pre-compression parameters of mixed blend were examined for angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, disintegration time, dissolution rate, content uniformity and drug content. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrate with enhanced dissolution can be made using selected superdisintegrants. Among all formulations, batch D4 was considered as best since it showed enhanced dissolution,...
Read More
