Posted by admin on Apr 1, 2011 in |
The ethanolic extract of whole plant of Coriandrum sativum Linn., family: Umbelliferae, was assessed for its possible analgesic, antidiarrhoeal, antimicrobial and cytotoxic activity. Preliminary phytochemical screening of the ethanolic extract revealed the presence of alkaloids, tannins, glycosides, and gums. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibited significant (p<0.001 & p<0.001) inhibition of writhing reflex 62.12% and 72.73% respectively compared to standard diclofenac sodium. The extract showed a significant (P<0.01 and P<0.001) antidiarrhoeal activity against castor oil induce diarrhea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 250 mg/kg and 500 mg/kg body weight. The ethanolic extract showed moderate antibacterial activity against both gram-positive and gram-negative bacteria. In the brine shrimp lethality test, the extract showed cytotoxicity significantly with LC50 40 μg/ml which was comparable to that of standard drug Chloramphenicol (LC50 20 μg/ml). All the results tend to justify the traditional uses of the plant and require further investigation...
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Posted by admin on Apr 1, 2011 in |
A series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C...
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Posted by admin on Apr 1, 2011 in |
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity in rats. Activities of liver marker enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins at an oral dose of ethanol extract of Balanites aegyptiaca (100 and 200mg/kg) showed a significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Balanites aegyptiaca exhibited a significant effect showing increasing levels of SOD, CAT, GPX and GRD by reducing malondialdehyde (MDA) levels....
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Posted by admin on Apr 1, 2011 in |
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of tinidazole was found to be irreversible so kinetic parameters (Ko fh, αn) are evaluated using Meites-Israel and Gaur-Bhargava’s methods. Thermodynamic parameters such as ∆Hp≠, ∆Hv≠, ∆G≠ and ∆S≠ are also evaluated....
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Posted by admin on Apr 1, 2011 in |
Nanodrop spectrophotometric method was developed and validated for the estimation of Ranolazine in bulk. Ranolazine exhibited λmax at 272nm in water and obeyed linearity in the concentration range of 12.5-2000 ppm. The proposed method has been applied successfully for the analysis of Ranolazine in bulk with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranolazine in...
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