Posted by admin on Oct 1, 2010 in |
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardant, binder and lubricant in isosorbide mononitrate sustained release tablets. The DCCSRA may be used for manufacturing of isosorbide mononitrate sustained release...
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Posted by admin on Oct 1, 2010 in |
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dissolution rate. The purpose of the present study is to design a sustained release matrix tablet containing micronized carvedilol phosphate. Phospahte salt of carvedilol possesses better aqueous solubility than it’s free base. Hydroxy propyl substituted β cyclodextrin and poly ethylene oxide are used as release modifying polymer to develop the matrix tablet. The comparative in vitro evaluation between the developed micronized sustained release and non-micronized sustained release matrix tablet of carvedilol are done. A significant increase in in vitro drug release rate is observed in case of the micronized product over the non micronized one. The sustained release matrix tablet of micronized carvedilol may be used as a...
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Posted by admin on Oct 1, 2010 in |
The present study was designed to investigate the effect of diosmin on the levels of glycoprotein components in plasma and tissues of streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (45 mg/kg b. w). Diosmin (DS) (100 mg/kg b. w) was administered orally for 45days. The effects of diosmin on plasma glucose, plasma insulin, plasma and tissue glycoproteins were studied. The levels of plasma glucose and plasma glycoproteins were increased significantly whereas the level of plasma insulin was significantly decreased in diabetic rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine and fucose in the liver and kidney of diabetic rats. Oral administration of diosmin to diabetic rats led to decreased levels of plasma glucose and plasma glycoproteins. The levels of plasma insulin and tissue sialic acid were increased, whereas the levels of tissue hexose, hexosamine and fucose were near normal. The present study indicates that diosmin possesses...
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Posted by admin on Oct 1, 2010 in |
Modern medicines are gaining less attention due to their limited availability and affordability in human intestinal helminthesis. Thus, most of the world’s population depends to a greater extent on traditional medical remedies. Carissa spinarum, Linn. (Apocynaceae) is a small spinous, evergreen shrub growing throughout India in dry regions. Further, C. spinarum roots are traditionally used for their purgative properties as well as to treat worm infested wounds in animals. There is no report on pharmacologically evaluated antihelmintic activity of root extract of C. spinarum till date. Therefore, in the present study we have investigated the antihelmintic activity of methanolic, aqueous and chloroform extracts of root of C. spinarum on Pheretima posthuma. The fresh and dried root of C. spinarum were collected in the month of November from the Bilaspur region, Chhattisgarh state, India, and the antihelmintic activity was evaluated in terms of time taken to cause paralysis and death of the adult Indian earthworm Pheretima posthuma. Piperazine citrate (PC; 10 mg/ml) was included as reference compound. The present investigation...
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Posted by admin on Oct 1, 2010 in |
Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO- from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO-) and to inhibit total reactive oxygen species (ROS) generation, in kidney homogenates using 2′,7′-dichlorodihydrofluorescein diacetate (DCHF-DA). A methanol (MeOH) extract of the B. monniera showed strong ONOO- scavenging activity in the ONOO- system ( IC50 = 11.23±2.14 µg/ml), and marginal activity in the total ROS systems (IC50 = 46.52±0.91µg/ml). So the MeOH extract was fractionated with several organic solvents, such as dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and n-butanol (n-BuOH). The EtOAc soluble fraction, showed strong activity in all the model systems tested. The Brine shrimp lethality bioassay method was used to determine the toxicity of the extracts where Vincristin sulphate was used as a positive control. The dichloromethane (CH2Cl2) fraction showed highest activity (LC50 = 19.02 ± 1.16 µg/ml) and other...
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