Posted by admin on May 31, 2023 in |
Medicinal plants contain phytocompounds which are of medicinal value. Scientific evaluation of these compounds that may serve as potential drugs is important in validating the medicinal plants. The leaf extract of the medicinal plant, Isodon ternifolius (D. Don) Kudo was prepared by the maceration method using 80% aqueous methanol as the extraction solvent. The resulting extract was subjected to gas chromatography-mass spectrometry (GC-MS) analysis. The mass spectra of all the major phytocompounds obtained were compared with the standard mass spectra found in the NIST and Wiley libraries, and the phytocompounds were identified. All these identified phytocompounds were characterized biocomputationally with respect to their pharmacologically relevant physicochemical properties, viz. molecular weight, number of heavy atoms, number of heavy aromatic atoms, fraction Csp3, rotatable bond, hydrogen bond acceptor, hydrogen bond donor, molar refractivity and topological polar surface area. Further, drug-likeness, bioavailability, and ADMET properties of each of the phytocompounds were also characterised. The results obtained may be useful in further in-vitro and in-vivo experimentation that might lead to the discovery of drugs...
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Posted by admin on May 31, 2023 in |
Indeed, Actinomycetes and Penicillium are microorganisms that live in different ecosystems. Besides, they play important roles in various fields in respect such as agriculture, medicine and the environment. During this study, we were interested in the isolation of two strains namely: Actinomycetes and Penicillium sp. from coconuts and truffle respectively. In addition, the agar cylinder technique demonstrated the antibacterial activity of Penicillium sp. against four pathogenic bacterial strains (S. aureus, E. coli, P. aeruginosa and K. pneumoniae). In virtue of which, the results showed a variability of the diameters of the inhibition zones, thus the most important results were recorded against K. pneumoniae and S. aureus, which produced inhibition zones of 17.50±0.71 mm and 17.00±0.00 mm respectively. In order to struggle against pathogenic fungal strains, the ability of Actinomycete strain to suppress the mycelial growth of 03 pathogenic strains of Fusarium oxysporum f.sp. albedinis (EF1, EF2 and EF3) was examined. Hence, the result of the direct confrontation tests on the PDA medium between the Actinomycete strain and these pathogenic...
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Posted by admin on May 31, 2023 in |
The present paper deals with the investigation of comparative physicochemical and phytochemical screening of five medicinal plants viz., leaves of Gymnema sylvestre, fruits of Momordica charantia, rhizomes of Curcum alonga, seeds of Eugenia jambolana and fruits of Embilica officinalis widely used in the treatment of diabetes. In the present communication, comparative results were shown. Various macroscopic, physicochemical, and phytochemical parameters were analyzed and...
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Posted by admin on May 31, 2023 in |
Background: Herpes simplex virus (HSV) are one of the most important viruses that causes a variety of life-threatening diseases in humans and the chemotherapeutic agents available for HSV infections are limited in efficiency. The formulation from Unani system of medicine was taken for antiviral assay which has already been established as anti-oxidants, immuno-modulator, anti-inflammatory activity in order to not only to reduce the viral-infection but also to maintain the homeostasis. Objective: Tiryaqwabai (TW) is a formulation in Unani system of medicine which was used by traditional healers and scholars like Avicenna and Galen in healthy and in sick people for its prevention and therapeutic effects during epidemics like cholera, plague and other diseases. Antiviral activity of the three components have been established in-vitro against HSV-1. The study was done to evaluate the synergistic effect of the formulation for HSV-1. Methods: TW was screened for its cytotoxicity against Vero cell line by microculture tetrazolium (MTT) assay. Antiviral properties of Tiryaqwabai (TW) were determined by cytopathic effect inhibition (CPE) assay and...
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Posted by admin on May 31, 2023 in |
The study represents the ethnobotanical information of the medicinal plants used by the six major communities of Assam, namely Mishing, Deori, Ahom, Tiwa, Bodo and Rabha, for better understanding of their local beliefs, customs, and tradition in the preparation of traditional rice beer starter culture. A semi-structured questionnaire was used focusing on the local names of the plants used in a starter culture, parts used, the reason for their use in the preparation, and other medicinal properties. A total of thirty-six plants were found to be used in the preparation by the Mishing community, twenty-seven plants by the Ahom community, thirteen plants by the Deori community, twenty plants by the Tiwa community, and seven plants by Bodo and Rabha communities for their respective starter cultures. A total of fifty-one plants were documented from the study, many of which were commonly used by all the communities to prepare rice beer starter culture and in their traditional health care system for curing many diseases. There is a dearth of information on...
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