Posted by admin on Feb 28, 2025 in |
Background: Hypertension is a prevalent health concern, often managed using Fixed Dose Combinations (FDCs) of antihypertensive drugs. Presently many FDCs are present in market without being assessed for safety efficacy and rationality, therefore evaluating the rationality of FDC usage is crucial for ensuring effective treatment and patient safety. Objective: This study aims to assess the rational use of fixed dose combinations in hypertension management at a tertiary care hospital. Methods: A prospective, observational study was conducted between March 2024 to July 2024. In this study a total of 93 outpatients were evaluated for prescribing pattern and rationality of Antihypertensive FDCs. Rationality was assessed using seven-point criteria. Data on patient demographics, prescribed FDCs, efficacy and dosing convenience were collected and analysed. Results: In this study, the prescriptions of 93 patients were analysed to observe 11 different fixed-dose combination antihypertensive agents. Of these patients, 56% were prescribed dual combination therapy. The most frequently prescribed dual combination was Telmisartan + Hydrochlorothiazide (17%), with Telmisartan + Chlorthalidone following at 14%. Analysis of the...
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Posted by admin on Jan 31, 2025 in |
A method by using a quality-by-design approach for the development and validation of an RP-HPLC method for determination of Acalabrutinib in API and marketed formulation. Chromatogram was run through SunFire C18 Column, 100Å, 10 µm, 4.6 mm X 150 mm. Mobile phase containing 0.1% OPA: Ethanol and water (50:50) taken in the ratio 60: 40 (%v/v) was pumped through the column at a flow rate of 1.0 ml/min. Temperature was maintained at 30°C. The optimized wavelength selected was 220nm. The retention time of Acalabrutinib was found to be 2.343 min %RSD of the Acalabrutinib was found to be 1.0%. %RSD of Method precision of Acalabrutinib was found to be 0.3%. %Recovery was obtained as 100.47% for Acalabrutinib. LOD, LOQ values obtained from the regression equation of Acalabrutinib were 0.28, 0.86. The regression equation of Acalabrutinib is y = 17109x + 5534.8. The method was easy to use and cost-effective, making it suitable for frequent quality control testing in industries. Both retention times and run times were reduced. Results which...
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Posted by admin on Jan 31, 2025 in |
The objective of this study is to develop and assess an herbal anti-dandruff shampoo that emphasizes safety and efficacy through the use of natural ingredients. Recognizing that healthy, vibrant hair is a key element of beauty, this shampoo is designed to effectively cleanse dirt and dandruff, promote hair growth, enhance lustre, and strengthen and darken the hair. Given the shampoo sector’s significant role in the hair care market, it is essential to address the growing concerns regarding the chemical ingredients commonly found in these products, which have been criticized for their potential side effects. The primary aim is to remove harmful synthetic components from the anti-dandruff shampoo formula and replace them with safe, herbal alternatives. This study mixes modern formulation techniques with natural ingredients. The shampoo was prepared using extracts from various herbal substances, including Orange Peel Powder (Citrus aurantium Dulcis – Rutaceae), Shikakai (Acacia concinna – Fabaceae), Curry leaves (Murraya koenigii – Rutaceae), Ginger (Zingiber officinale – Zingiberaceae), Aloe Vera (Aloe Barbadensis Miller – Asphodelaceae), and Reetha (Sapindus...
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Posted by admin on Jan 31, 2025 in |
Sargassum wightii,a seaweed and a marine macroalgae, is known to offer numerous health benefits, and compounds isolated from it are observed as the alternative to conventional treatment as an affordable plant-derived drug. In the present study, the bioactivity of the two fractions from Sargassum wightiiw as derived using two different solvents, methanol and acetone: methanol. Acetone: Methanol fraction showed better yield. Both the fractions it was tested against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria. The antioxidant potential was evaluated by the reducing power assay. Fucoxanthin extracted by maceration in methanol: acetone (9:1) showed more excellent antioxidant activity. The partially purified extract was also analysed through the FT-IR spectra. The extract prepared by methanol: Acetone extract performed better than streptomycin, but compared to streptomycin, none of the extracts showed significant antibacterial action at higher concentrations. The FT-IR spectra showed various secondary metabolites and their derivatives in the crude...
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Posted by admin on Jan 31, 2025 in |
The present work focused on preparing ethanolic extract of Petunia hybrida and evaluating its anti-diabetic potential in rats. The extraction of flowers was carried out using ethanol and the extraction yield was found to be 21.7% w/w. The total phenolic content of ethanolic extract of Petunia hybrida was found to be 39.18±1.46 GAE mg/g. The antidiabetic action of the extract was evaluated in terms of the effect of extract on body weight and serum glucose level. Other parameters like cholesterol and serum urea were also evaluated. The results revealed that the serum glucose levels were highly elevated by the administration of STZ in all the groups by day 7. In treatment groups III to V, the glucose levels dropped in comparison to group II and by the day 21, the levels reached almost the level of control group in group III and V. This indicates that the extract exhibits significant glucose lowering potential. Both SGOT and SGPT enzyme levels get elevated during liver damage which is more in diabetic...
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