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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Mar 31, 2023 in |

DESIGN, DEVELOPMENT AND OPTIMIZATION OF NOVEL NANOVESICLE LOADED SUBGLOSSAL FILMS FOR ENHANCED SYSTEMIC AVAILABILITY OF TACROLIMUS THROUGH SUBLINGUAL ROUTE

Tacrolimus being the drug of choice in prevention of transplanted organ from rejection suffers from low oral bioavailability and dose-dependent side effects. An attempt was made to formulate tacrolimus into subglossal (sublingual) fast dissolving films containing ethosomes using ethanol and soyalecithin to enhance systemic availability of drug with controlled delivery of drug. Ethosomes were prepared by modified mechanical dispersion method and were optimized by central composite design to arrive for best drug-loaded ethosome dispersion. Optimized formulations were characterized for vesicle size, Deformability index and entrapment efficiency. Subglossal films were prepared for best and optimized dispersion using HPMC K15M and PEG-400 as film-forming polymer and plasticizer respectively. Formulated fast dissolving subglossal films were optimized by Box benhkendesign and characterized for physical characteristics like appearance, pH, thickness, disintegration time, in-vitro release, Histopathology studies, stability and in-vivo pharmacokinetics in rats. Higher drug plasma levels were shown by optimized subglossal film when compared with that of oral pengraf capsules. These results suggests the potential of nanovesicle fast dissolving films as effective drug carriers...

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Posted by on Mar 31, 2023 in |

IDENTIFICATION AND CHARACTERIZATION OF NOVEL PHYTOCONSTITUENTS FROM THE FERMENTED EXTRACT OF LEAVES OF MORINGA OLEIFERA BY GC-MS ANALYSIS

Moringa oleiferais a well-known plant that can be used for the treatment of various disorders or nutritional deficiencies; all parts of this plant possess various activities such as antitumor, antipyretic, antiepileptic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol-lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities and are being employed for the treatment of different ailments. Numerous bioactive compounds were found to be present in the fermented extract of Moringa oleifera with therapeutic activity having great research value by pharmaceutical industries. The fermented extract of Moringa oleifera leaves was analyzed by gas chromatography-mass spectroscopy for the identification and characterization of phytoconstituents and their therapeutic efficacy. The existing compounds identified in extract were Diethyl Phthalate (56.05%), dl-Mevalonic acidlactone (10.40%), 4H-Pyran-4-one, 2, 3-dihydro-3, 5-dihydroxy-6-methyl (8.88%), Bis(2-Ethylhexyl) phthalate (2.99%), 5-Fluoro-6-methyl-5-hepten-2-one (2.42%). Beta-D-,glycopyranoside, methyl (1.94%), glyceraldehydes (1.71%), 2-propen-1-one, 3-[(1,1-dimethylethyl) thio]-1(1.67%), 1,2,3-propanetriol, diacetate 1.16%), 2,4-dihydroxy-2,5-dimethyl-3(2h)-furan-3-one(1.12%), 2-cyclopenten-1-one, 2-hydroxy-(0.99%), 4-(1-hydroxy-ethyl). gamma. Butanolacton (0.98%), 1,3,5-triazine-2,4, 6-triamine (0.92%), 2(3h)-furanone, 5-acetyldihydro(0.86%), dihydro-5-(1-hydroxyethyl)-2(3h)-furanone (0.85%), docosyl ethyl ether(0.77%), benzeneethanol, 4-hydroxy(0.67%), benzene acetic acid (0.61%), benzene, 1,1′-sulfonylbis-(0.59%), 2-propanamine, n-methyl-n-nitroso (0.59%), 1-heptanol(0.58%), 3,4,5-trimethoxyphenol (0.41%), phenol,...

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Posted by on Mar 31, 2023 in |

A COMPARATIVE STUDY ON THE ANTI-CANCER POTENTIAL OF ENICOSTEMA AXILLARE ON CANINE AND HUMAN BREAST CANCER BY TARGETING RUNX AS A PROGNOSTIC MARKER

The main objective of this study is to find a cure for Human Breast Cancer having Canine Mammary Tumor as a model using the ethyl acetate extract of Enicostema axillare targeting Runt-Related Transcription factor, which plays a vital role in Hippo Signaling Pathway. The preliminary phytochemical analysis and GC-MS analysis were used to determine the plant extract’s bioactive compounds. The in-vitro Antioxidant and Anti-Proliferation assay was performed on MCF-7 and REM-134 cell lines by MTT assay. The Pharmacokinetics and Pharmacodynamics of Bioactive compounds were studied using Pre-ADMET and PASS SERVER software, respectively. Minimum Antioxidant potential Inhibition of extract was observed at 40µg/mL, and IC50 value calculated by MTT assay was found to be 31.2µg/mL for MCF-7 and 125µg/mL for REM-134. Bioactive compounds obtained from the GC-MS study were subjected to molecular docking on RUNX of Humans and Canine. The Dock score was found to be 96.7 for Humans and 102.13 for Canine. RUNX can be used as a prognostic marker for the treatment of mammary tumors for both Human...

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Posted by on Mar 31, 2023 in |

COMPUTER-BASED SCREENING OF THE ANTICANCER PROPERTY OF SELECTED PANAX GINSENG PHYTO-LIGANDS

It cannot be overstated that the rate at which cancer uses glucose for proliferation is one of the many variables contributing to the alarmingly high mortality rate of cancer over time. Cancerous cells can survive because of this. However, a significant therapeutic strategy for malignant cells may involve the blockage of several glucose transporters, including glut 4 encoded by the solute carrier family-2-member-4-gene (Slc2a4) by certain phytochemicals from Panax ginseng. The top ten phytochemicals obtained from the PubChem database in SDF format with the lowest binding energies of these compounds wit SGLUT4 were selected as possible inhibitors of GLUT4 from Panax. Glut 4 complexed with cytochalasin B was retrieved from the protein data bank (Rcsb.pdb). Schrodinger, online tools such as ProTOX, swissAdmet and Spartan 10.1 were used to examine the samples’ Mmgbsa, Admet characteristics, drug-likeness, toxicity prediction and DFT. The results of this in-silico study showed that the docking scores of the 10 compounds were higher than those of the co-crystallized compound. The Lipinski rule of five (RO5) and...

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Posted by on Mar 31, 2023 in |

AN EXPERIMENTAL STUDY TO ASSESS THE MEMORY-ENHANCING PROPERTY OF PITAVASTATIN AND GEMFIBROZIL IN MICE USING THE MORRIS-WATER MAZE MODEL. EVIDENCE TO CATEGORIZE THEM AS SMART DRUGS

Introduction: Discovery of smart drugs is part of advancing the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters; they also act as memory enhancers that help quick decision-making. Pitavastatin and gemfibrozil both cause lipid-lowering effects by different mechanisms of action. A few studies show they can act on CREB (c-AMP response elemental binding protein), a known transcription factor. CREB performs an essential role in long-term memory restoration. Aim and Objectives: To evaluate the memory enhancer effect of pitavastatin and gemfibrozil compared to piracetam using Balb-c mice. Material and Methods: The escape latency period and time spent in the target quadrant were compared among four groups. Observations were analyzed by using paired t-tests, ANOVA, and post hoc Tukey’s test. Results: Pitavastatin (30mg/kg) and gemfibrozil (60mg/kg) significantly decline in the escape latency period. pitavastatin increased the total time spent in the target quadrant as compared to vehicle control in the Morris-water maze test (p< 0.01). However, gemfibrozil fails to show any increment in spending...

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