Posted by admin on Jan 31, 2023 in |
Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder. It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone. However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability. In the present research, GSH content were significantly decreased in arthritic control group when compared to normal control group. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, causes increase in GSH content, which was comparable with standard drug Dexamethasone. Change in body weight is in response to the incidence and severity of arthritis and used to assess disease onset. Weight loss is associated with increased production of pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1. Adjuvant arthritis is characterized by reduced body weight. The body weight of arthritic control rats decreased compared to the normal control group due to FCA administration. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, recovered the body weights, significantly which was comparable with standard drug Dexamethasone....
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Posted by admin on Jan 31, 2023 in |
Background: Pityriasis Versicolor (PV) is a cutaneous fungal infection of the skin revealed by changes in skin pigmentation due to colonization by a dimorphic lipophilic fungus of the skin, known as Malassezia furfur. There is an impact on the psychological status of patients resulting in anxiety or depression. This disease is predominant in warm and hot climates. Currently, no ideal drug of choice exists with minimal side effects to treat PV. Objective: To assess the incidence, characteristics of the lesions, and effectiveness of the herbal procedure. Aim: To treat PV individuals with herbal treatment by minimizing side effects. Methods: The herbal cure was chosen based on a preferable study; different types of herbs used are Neem powder, herbal baths, turmeric, and streaming, which helped to clear PV patches present on the skin. The diagnosis is clinical, but a direct examination must be done. The present clinical research study is on the potentiation of the body’s ability to eliminate PV by manipulating the diet and managing lifestyle for PV. Results:...
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Posted by admin on Jan 31, 2023 in |
Introduction: Alcohol de-addiction is challenging due to the severe alcohol withdrawal symptoms. This article reports ameliorative effect of KalyanakGhrita (KG) on ethanol withdrawal symptoms in animal model. Material and Methods: After approval from Animal Ethics committee, alcohol dependence was developed in pre Rota road trained Swiss mice by intermitted access of 20% ethanol in 14 days. After confirmation of dependence, the animals were allocated in 6 groups, 6 animals in each group. Group I &II received distilled water & ethanol respectively. Group III to VI received cow ghee, KG in two dose level and Naltrexone respectively along with ethanol till next 14 days. Further alcohol abstinence was given but treatment drugs were continued for next 7 days. To note the effect of KG on withdrawal symptoms, animals was introduced to Rota rod on 0 day and 3rd day for muscular incoordination and to EPM on day 0 day & 7th day after abstinence of ethanol for anxiety assessment. Results: KG higher and lower dose demonstrated significant reduction in anxiety...
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Posted by admin on Jan 31, 2023 in |
The Hemagglutinin (HA) protein of the Influenza virus plays a vital role in viral replication. In this study, numerous small molecules were screened systematically against the HA protein to find a compound that can bind to it selectively. The HA protein’s three-dimensional crystal structure was obtained from RCSB PDB and inputted into the FTMap Web Tool to identify the best possible drug gable hotspot. Over 68 million compounds from the ZINC-15 database were filtered for drug-likeness properties and narrowed down to 250,000 ligands. These chosen molecules were then tested for their binding affinity to the selected hotspot on the HA protein using the CLC Drug Discovery Software. The top 100 molecules with the highest binding affinity were tested for ADMET properties using the admet SAR web tool. Six compounds that satisfied the given conditions were then subjected to a more intensive binding affinity test using the AutoDock Vina program of the PyRx software. The molecule with the highest binding affinity to HA, 6-(4-Methylpiperidin-1-yl) sulfonyl-1-azatricyclo [6.3.1.04, 12]dodeca-4,6,8(12)-trien-2-one, was selected as...
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Posted by admin on Jan 31, 2023 in |
The present study aims to evaluate the in-vitro antioxidant, in-vitro α-amylase inhibition, in-vitro and in-vivo anti-cataract potential of ethyl acetate root extract of Abutilon indicum. Antidiabetic activity was evaluated against alpha-amylase by spectrophotometric assays. DPPH determined antioxidant activity, Reducing power assay, Phosphomolybdenum antioxidant assay, Nitric oxide-scavenging activity, Hydrogen peroxide scavenging, and Hydroxyl radical scavenging assay. Different extract concentrations were made using dimethyl sulfoxide (DMSO) and subjected to an α-amylase inhibitory assay. The in-vitro anticataract potential of Abutilon indicum was determined using glucose-induced cataractous goat eye lens. In the in-vivo group, cataract was induced in rats by 30% galactose diet alone (control) or with the addition of Abutilon indicum (treated group). The results indicate the dose-dependent in-vitro antioxidant activity against DPPH, Reducing power assay, Phosphomolybdenum antioxidant assay, Nitric oxide-scavenging activity, Hydrogen peroxide scavenging, and Hydroxyl radical scavenging comparable with that of standard Ascorbic acid and also appreciable α-amylase inhibitory activity with IC50 values comparable with that of standard Acarbose. An in-vitro study was conducted, which reported that the lens group...
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