Posted by admin on Aug 31, 2025 in |
The objective of the present study was to develop a time-controlled floating pulsatile drug delivery system of Ritonavir (RIT), an antiviral drug with low oral bioavailability due to degradation by CYP3A4 enzymes, efflux by P-glycoprotein, and instability at alkaline pH. Ritonavir is primarily absorbed in the stomach; hence, a floating pulsatile release system was designed to enhance absorption and therapeutic efficacy. Core tablets of Ritonavir were prepared using different superdisintegrants and evaluated for in-vitro disintegration. The disintegration time varied from 21–44 seconds, with crosspovidone showing the fastest disintegration due to rapid water penetration compared with croscarmellose sodium and sodium starch glycolate. Since rapid disintegration is critical for burst release, the F3 formulation was selected for further studies. The rapid release core tablet (F3) was compression-coated with varying concentrations of HPMC K4M, HPMC K15M, and HPMC K100M (P1–P9). Formulations with HPMC K100M (P7–P9) showed a lag time of 4–4.5 hours followed by sigmoidal release, achieving 100% drug release by 10–12 hours. Among these, P9 (core 100 mg + 180 mg...
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Posted by admin on Aug 31, 2025 in |
Amoxicillin is an antibiotic beneficial for the treatment of some bacterial infections. When orally administered it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Amoxicillin and produce sustained drug delivery. Microspheres can be manufactured from various natural and synthetic materials. In these 14 batches of Amoxicillin, microspheres were prepared using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were evaluated for different parameters i.e % drug yield, % drug entrapment, shape, surface morphology, particles size, polydispersity index, zeta potential and in-vitro drug release for 48 hours in phosphate buffer 7.4. The best batch performed stability studies for 6 months. The research concluded that Amoxicillin microspheres could be an alternative for conventional dosage form and other phytochemical in herbs. The optimized formulation was found with significant loading...
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Posted by admin on Aug 31, 2025 in |
Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habits convert to diseases like obesity, type 2 diabetes mellitus (T2DM), dyslipoproteinemia etc. This case-control study was carried out in the Department of Biochemistry in collaboration with the Department of General Medicine, Madhav Prasad Tripathi Medical College, Siddhartnagar to explore the status of blood sugar fasting (BSF), tumor necrosis factor-α (TNF- α), Insulin, Insulin resistance, antioxidant enzymes and lipoprotein profile by standard spectrophotometric kit methods, as well as anthropometric measurements, blood pressure (BP) with the help of suitable instruments and equipment’s in Control group and Obese with T2DM group. A marked impairment observed in levels of lipoprotein profile accompanied by an increase in the lipids and apo-protein levels of serum β lipoproteins, lipid peroxide, Insulin and Insulin resistance, blood pressure, anthropometric measurements following the decrease in lipid and apo-protein constituents of α lipoprotein. Also...
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Posted by admin on Aug 31, 2025 in |
Traditionally, alopecia, a major illness throughout the world, has been treated with medicinal plants and their oils. Hair treatments, including those that stimulate hair growth, cost about $10 billion a year. A big worry is hair loss, which is mostly brought on by junk food and erratic lifestyle choices. The function of the ethanolic extract of the entire A. indica plant is examined in this study. Polar components like alkaloids, flavanoids, glycosides, terpenoids, and salts were detected by qualitative screening after Soxhlet extraction. At the maximum dose of 2000 mg/kg, 14 rats in acute toxicity trials exhibited no behavioral abnormalities, a modest increase in weight, and no mortality. At 500 mg/kg and 1000 mg/kg doses, the in-vivo hair growth boosting activity on 24 rats demonstrated effectiveness in activating hair follicles, increasing the number of hair follicles, and promoting hair growth. The results of the study demonstrate the effectiveness of the entire A. indica plant and offer a formulation approach for creating hair...
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Posted by admin on Aug 31, 2025 in |
Background: The present investigation was aimed at developing, optimize and evaluate gastroretentive floating tablets containing Losartan potassium to retain in the stomach for prolong and predictable period of time for hypertensive patients. In the present study, the effect of HPMC K15M showed prolong release of drug in gastric pH environment. Results: These formulations were evaluated for the parameters like drug excipient compatibility study, thickness, hardness, tablet density, floating lag time, total floating time, weight variation test, % friability, drug content, % swelling index and accelerated stability studies. On the basis of preliminary results, the amount of HPMC K15M (X1) and the amount of MCC (X2) were chosen as independent variables in 32 full factorial design while % Friability (%F) and Cumulative % drug release at 12 hrs (Q12) were taken as dependent variables. Multiple linear regression analysis, ANOVA and graphical representation of the influence of factors by contour plots were performed using Design Expert. In-vitro release data were fitted to various models to ascertain kinetic of drug release. The...
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