Posted by admin on Aug 31, 2022 in |
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospective comparative observational study carried out at the Department of Gastroenterology of tertiary care hospital. A total of 38 patients were allowed to participate in the study and randomized into two study groups, Group I and II. Each group consists of 19 patients. Patients in group I treated with UDCA. Group II patients treated with OCA. Results: The most common symptoms observed in the two study groups were nausea /vomiting followed by loss of appetite and abdominal pain. Both Group I and II patients showed significant improvement in their symptoms after treatment. The mean of liver function test (LFT) parameters was compared before and after treatment....
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Posted by admin on Jul 31, 2022 in |
Mosquitoes are carriers of the DENV and ZIKV diseases. DENV and ZIKV are epitopes. The current performance and technique of some of the most frequently used B-cell epitope predictors used for DV and ZV proteomes are reviewed in this paper. Our specific prediction methods, ABC pred, BC pred, and AAP Methods, as well as FBC pred, were utilized to predict 1529 B cell epitopes. For the B cell epitops, the stability index, aliphatic index, GRAVY, antigen city, allergen city, toxicity, clustering, and conservancy were investigated further. The anticipated immunogenic epitopes PLPWHAGADTGTPHWNNKEA, GGFGSLGLDCEPRTGLDFSD of ZIKV and IGVEPGQLKLSWFKKGSSIG, VEPGQLKLSWFKKGSSIGQM, IEAKLTNTTTASRCPTQGEP, LPLPWLPGADTQGSNW of DENV were 100 percent conserved. The goal of this study is Flaviviridae viruses that now affect 128 nations throughout the world. And they may both be fatal and life-threatening. A quicker and less expensive vaccine design procedure used to identify the B cell was to use computer simulations to find potential vaccination candidates and antiviral efficacy testing. The study’s goal is to develop patient therapies that are both safe...
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Posted by admin on Jul 31, 2022 in |
Background: Colorectal cancer is the fifth most common cancer and the leading cause of cancer-related deaths in India. The incidence, mortality, and prevalence rates are consistently higher. Precautionary measures in preventing colorectal cancer still remain a challenging issue. Aims and Objectives: This study was undertaken to correlate the specificity, sensitivity & efficiency of TIMP-1 and MIF protein that are non-invasive and enable us to detect CRC quite early. Analysis of CEA, Ca19-9, Fecal Hemoglobin were done as diagnostic markers & TIMP-1, MIF protein, CRP, prolactin as prognostic and molecular markers. Total 120 patients were included in the study and categorized as stage I-IV with recurrences and without recurrences which were compared with healthy controls. Results: The study observed increased CEA, CA19-9, fecal Hb in various stages of colorectal cancer as compared to control. Prolactin, CRP, TIMP-1, MIF Protein show significant (p<0.001) rise in various stages. The elevated levels are increased concomitantly from stage 0 to IV suggesting the severity and distance spread of the disease. CEA, CA19-9, and fecal...
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Posted by admin on Jul 31, 2022 in |
For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity of 4-[(2-oxo-2-[5-(2-oxo-2H-chromen-3-yl)-1, 3-thiazol-2-yl] aminoethyl] amino] benzoic acid was comparable to that of ciprofloxacin and fluconazole. The reaming compounds had moderate to good...
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Posted by admin on Jul 31, 2022 in |
Diarrhea alters the movement of ions and water that follows an osmotic gradient and leads to Loose, watery stools, abdominal cramps, abdominal pain, fever, bloating, blood, and mucus in the stool. Numerous critical cases have been observed in both infants and adults. The main objective of this study is based on an exploration of risk factors of diarrheal infection caused in neonates by entering pathogenic Bactria. The enteric infections responsible for diarrhea are the major cause of morbidity and mortality worldwide, while 2–4 billion cases of diarrheal infections in infants occur worldwide every year. The major microbes associated with diarrheal infection belong to all the major groups, including viruses, bacteria and protozoans. Amongst various pathogenic factors, preferred bacterial pathogens have been considered as classical organisms for the study of diarrhea viz the strains of Escherichia coli for ion absorption mechanisms, Clostridium difficile and Shigella spp. as inflammatory diarrhea and Vibrio cholera for secretory diarrhea. The current study is focused on the members of Enterobacteriaceae, including the strain of E....
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