Posted by admin on Aug 31, 2021 in |
Background: Psoriasis is an immune-mediated inflammatory disease characterized by excessive growth and abnormal differentiation of keratinocytes. Objective: In the present research work, an attempt has been made to formulate and evaluate gel containing cyclosporine, aloe vera and tree tea oil. Methods: The gel was prepared by a conventional method and evaluated for various parameters viz., physical appearance, pH, drug content, viscosity, spreadability and in-vitro diffusion studies, In-vitro skin retention studies and stability studies. The prepared optimized gel was further compared with marketed formulation; all the formulations were good in appearance and had good homogeneity. Results: The optimized gel is shown spreadability co-efficient is 5.8 g cm/sec. The gel has shown 95 ± 0.32% releases in 6 h when evaluated for in-vitro diffusion studies. The biological evaluation of the optimized gel has shown 47.98 % drug activity, indicating good efficacy of the formulation against psoriasis. Conclusion: In conclusion, the prepared optimized gel has shown good spreading co-efficient and stability and can be effective for psoriasis as compared to available gel...
Read More
Posted by admin on Aug 31, 2021 in |
The crude drug powder extracts from three plants Datura metel L., (Solanaceae), Leucas cephalotes (Roth.). Spreng, Piper betel L., (Piperaceae) were screened for estimating phytochemical constituents. Phytochemical analysis of the extracts revealed that glycoside; tannin, saponin, carbohydrate and phenolic compounds are present in Piper and Leucas species. Besides glycoside, tannin, saponin, carbohydrate and phenolic compound, alkaloid is also present in Datura species. The antimicrobial activity of the plant materials and their usefulness in the treatment of asthma may be due to the presence of active constituents like tannins, alkaloids and phenolic. The present study reported that the phytochemical constituents of three plants being widely used for traditional treatment of asthma in Myanmar, collected from Kalay, Sagaing...
Read More
Posted by admin on Aug 31, 2021 in |
Scurrula parasitica L. is a parasitic plant, traditionally used by the people of Mizoram for the treatment of various diseases, and locally called Vatesawi. The bioassay-guided purification of the methanol extract of the leaves of Scurrula parasitica L. led to the isolation of 2-(3, 4-dihydroxy phenyl)-3,5,7-trihydroxy-4H-Chromen-4-one. Quercetin is a flavonol that belongs to one of the subclasses of flavonoids. For separation and purification of compounds, thin layer chromatography and column chromatography were performed using the plant extract. Then identification was done by high-performance liquid chromatography (HPLC) with mass spectral analysis, and confirmation of the isolated compound was performed with thin layer chromatography. The results showed that the solvent system of ethyl acetate 7: chloroform 3 had accurate separation, and the fraction no-200 from column chromatography was processed for identification of the compound. Structures were established with the mass spectrum and confirmation of the compound was done by comparing with standard quercetin, and both appeared at the same wavelength of 254nm (RT...
Read More
Posted by admin on Aug 31, 2021 in |
Depression is a collective term used for the mental condition characterized by loss of interest, inability to concentrate, eat or sleep, reduced energy levels, together with reduced self-esteem. To date, the medicines available are often associated with several adverse conditions and fail to treat comorbidities it entails. Phosphodiesterase (especially its inhibitors) are recently gaining attention owing to their benefits on the central nervous system. With this background, the present study aimed to evaluate the anti-depressant activity of Roflumilast using albino mice. 8 groups of 6 albino mice of either sex were randomly selected, 4 groups were allocated for forced swim test (FST) and 4 for tail suspension test (TST). Group 1 – Normal saline (10ml/kg), Group 2 -Imipramine (20mg/kg), Group 3 T1 – Roflumilast (0.06mg/kg), Group 4 T2 – Roflumilast (0.06mg/kg) and Imipramine (10 mg/kg). Drugs were administered orally for 14 days. The acute study was done on day 1 and the chronic study on day 14. Percentage reduction of immobility period during FST by Imipramine, T1 and T2 are 51.9%, 37.5%,...
Read More
Posted by admin on Aug 31, 2021 in |
The development of anti-microbial agents, microorganisms that have acquired resistance to drugs through a variety of mechanisms, have emerged and continue to plague human beings. Since, the use of anti-microbial drugs has selected drug-resistant bacteria, the proper use of currently available anti-microbial drugs and efforts to minimize the transmission and spread of resistant bacteria through appropriate infection control would be the first step in resolving the issue of resistant organisms. Synthesize and characterize some metal complexes with Schiff base derived from substituted salicylaldehyde and amino acids by an efficient methodology. The synthesized compounds were evaluated for their in-vitro anti-microbial activity. Synthesized compounds were examined for Anti-bacterial activity using the disc diffusion method and antifungal activity using cup plate method. The bacterial strains of Escherichia coli [Gram negative] MTCC – 443, Staphyloco ccusaureus [Gram positive] MTCC – 96, Bacillus subtilis, and Salmonella typhi using norfloxacin as standard. The fungal strain of Candida albicans with fluconazole was used as standard. In-vitro anti-microbial data represent the cobalt-containing metal complex were most active...
Read More
