Posted by admin on Jan 31, 2020 in |
A new analytical method has been developed for the simultaneous estimation of Telmisartan and Hydrochlorothiazide in their pure and pharmaceutical dosage forms by using Fourier Transform Infrared (FTIR) Spectroscopy. This method involves the extraction of Telmisartan and Hydrochlorothiazide from tablets using chloroform and direct measurement in liquid phase mode using reduced path length cell. The spectra were measured in absorbance mode, equipment was configured to collect spectra at 8 cm-1 resolution, and the spectra were collected between 4000 cm-1 and 450 cm-1. The infrared spectra showed different peaks with baseline correction, among which intense, clear and proportionate peaks were selected at 3411 cm-1, and 1309 cm-1 corresponding to the N-H group and asymmetric SO2 group for Telmisartan and Hydrochlorothiazide respectively for quantitative estimation. Beer-Lambert’s law was obeyed over the concentration range of 50-250 μg/ml for Telmisartan and 25-125 μg/ml for Hydrochlorothiazide. All the results were found to be within the limits. The results obtained were compared statistically with that of HPLC by t-test, which indicated no significant difference between...
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Posted by admin on Jan 31, 2020 in |
The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal patch. The transdermal patch was evaluated for drug content, thickness, folding endurance. Ex-vivo permeation study for the prepared patch was conducted and, the permeation parameters and drug permeation mechanism were identified. The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied in their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 of 161 nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal...
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Posted by admin on Jan 31, 2020 in |
Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine. Initially the morphological observations were determined by using simple microscope. The shape of leaf, fruit, odor and type of flower were determined. The present study investigated the leaf anatomical characterization of upper and lower epidermis of Noni plant and also characterized the petiole and lamina of leaf. Finally, this study also explained the histochemical localization of various primary and secondary metabolites of stem of Morinda citrifolia was carried out with the aim of contributing to its quality control in herbal industries. The results of this study could be useful for correct identification of the plant species and also for the determination of the authenticity of the drug in...
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Posted by admin on Jan 31, 2020 in |
Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM images revealed nanostructure with linear/rod shape enabling better internalization. The X-ray powder diffraction analysis clearly indicates reduction in crystallinity of bendamustine in nanoparticles. The nanoparticle formulation showed good results in terms of assayed drug content and encapsulation efficiency. The in-vitro permeation studies using egg membrane revealed that F3 formulation showed a sustained drug release for 28 h with an initial burst release within 1...
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Posted by admin on Jan 31, 2020 in |
Escherichia coli is the predominant isolated type of bacteria in urinary tract infections in children. Multidrug resistance of this kind of infection is associated with an increased risk of kidney injury and, therefore, an increase in morbidity and mortality. This report presents a case of a 6-year-old child with recurrent pyelonephritis with multidrug-resistant E. coli. She was followed, in a teaching hospital and was successfully treated with daily cephalexin prophylaxis for about four years as a result of the collaboration of healthcare providers. Continued teamwork between health care providers, especially collaboration between the treating pediatric nephrologist and the clinical pharmacist, yielded better decisions to overcome the multidrug-resistant bacteria over the course of the disease in such a vulnerable child patient. This case lends support for the use of suppression therapy in pediatric patients with severe recurrent bladder and renal infections as well as support for the patient-centered approach in achieving improved pharmacotherapy and patient...
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